# A+ vs Mesoestetic Page: https://lovi.care/skincare/ca/compare/a-vs-mesoestetic The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Canada. A+ and Mesoestetic are distinguished skincare brands founded in 1990 and 1984, respectively, that offer thoughtfully calibrated formulas to elevate daily routines. A+ is widely beloved for its gentle moisturizers, suiting sensitive skin best, while the Spanish brand is known for its targeted [serums](https://lovi.care/skincare/ca/ingredients/serum) that suit mature, sensitive, and uneven skin. For acne-prone skin, the former features the 345 Relief Cream, and the latter offers the Cosmelan 2 for stubborn blemishes. Both brands differ in their geographic origins and specific standalone products, yet each reliably supports long-term skin health. A+ is an Indian skincare brand founded in 1990. [pitchbook.com](https://pitchbook.com/profiles/company/554388-85) Mesoestetic is a Spanish skincare brand founded in 1984 and owned by Mesoestetic Pharma Group, S.L.. [mesoestetic.com](https://www.mesoestetic.com/about-us) [tracxn.com](https://tracxn.com/d/companies/mesoestetic/__1eAnF7uALQzHII_So8HqZbHfSUJuilusj9hTisrG0tk) This page compares some of the most popular A+ and Mesoestetic products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg37fb1b2195). ### Popular A+ vs Mesoestetic products #### Mesoestetic - [Cosmelan 2](https://lovi.care/skincare/ca/p/mesoestetic/cosmelan-2/for/acne-prone-skin) — Average fit #### A+ - [345 Relief Cream](https://lovi.care/skincare/ca/p/a/345-relief-cream/for/sensitive-skin) — Average fit ## Questions and answers ### A+ or Mesoestetic: which is better? Neither A+ nor Mesoestetic is universally better, as Lovi rates both brands as having average or low fit levels across all listed skin types. Shoppers looking for fragrance-free options will find that every product on this page for both brands lists no fragrance. ### What is the difference between A+ and Mesoestetic? A+ is an Indian brand founded in 1990, while Mesoestetic is a Spanish brand founded in 1984, and both brands list no fragrance in the products on this page. ### Which is more affordable, A+ or Mesoestetic? The products on this page for both A+ and Mesoestetic do not list pricing details, so affordability cannot be compared. ### Which causes fewer breakouts, A+ or Mesoestetic? Both A+ and Mesoestetic have an average Lovi fit for acne-prone skin and oily acne-prone skin with the products on this page, and both are fragrance-free. ### Which brand is older, A+ or Mesoestetic? Mesoestetic is older, having been founded in 1984 in Spain, while A+ was founded in 1990 in India. ### Where are A+ and Mesoestetic headquartered? A+ was founded in India, and Mesoestetic was founded in Spain. ### Do any of the products from A+ or Mesoestetic contain fragrance? None of the products on this page from A+ or Mesoestetic list any fragrance in their ingredients. ## Research behind their key ingredients - [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002 - [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002 - [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018 - [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide np · International Journal of Dermatology, 2008 - [Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study](https://pubmed.ncbi.nlm.nih.gov/34211271/) Retinyl palmitate · International Journal of Nanomedicine, 2021 - [Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin](https://pubmed.ncbi.nlm.nih.gov/18503551/) Centella asiatica leaf extract · Experimental Dermatology, 2008 - [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021 - [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017 - [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021 - [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017 - [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024 - [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020 - [Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy](https://pubmed.ncbi.nlm.nih.gov/37446936/) Centella asiatica leaf extract · Molecules, 2023 - [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024 - [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) Ceramide np · Skin Pharmacology and Physiology, 2022 - [Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial](https://pubmed.ncbi.nlm.nih.gov/30945430/) Centella asiatica leaf extract · Journal of Cosmetic Dermatology, 2019 - [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024 - [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023 - [Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment](https://pubmed.ncbi.nlm.nih.gov/38460769/) Centella asiatica leaf extract · International Journal of Pharmaceutics, 2024 - [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025 ## The brands - Indian skincare: [A+](https://lovi.care/skincare/ca/brands/a) - Spanish skincare: [Mesoestetic](https://lovi.care/skincare/ca/brands/mesoestetic) ## More comparisons - [SKIN1004 vs A+](https://lovi.care/skincare/ca/compare/skin1004-vs-a) - [SKIN1004 vs Mesoestetic](https://lovi.care/skincare/ca/compare/skin1004-vs-mesoestetic) - [Anua vs A+](https://lovi.care/skincare/ca/compare/anua-vs-a) - [Anua vs Mesoestetic](https://lovi.care/skincare/ca/compare/anua-vs-mesoestetic) - [Medicube vs A+](https://lovi.care/skincare/ca/compare/medicube-vs-a) - [Medicube vs Mesoestetic](https://lovi.care/skincare/ca/compare/medicube-vs-mesoestetic) - [The Ordinary vs A+](https://lovi.care/skincare/ca/compare/the-ordinary-vs-a) - [The Ordinary vs Mesoestetic](https://lovi.care/skincare/ca/compare/the-ordinary-vs-mesoestetic) - [Beauty of Joseon vs A+](https://lovi.care/skincare/ca/compare/beauty-of-joseon-vs-a) - [Beauty of Joseon vs Mesoestetic](https://lovi.care/skincare/ca/compare/beauty-of-joseon-vs-mesoestetic) - [COSRX vs A+](https://lovi.care/skincare/ca/compare/cosrx-vs-a) - [COSRX vs Mesoestetic](https://lovi.care/skincare/ca/compare/cosrx-vs-mesoestetic) - [CeraVe vs A+](https://lovi.care/skincare/ca/compare/cerave-vs-a) - [CeraVe vs Mesoestetic](https://lovi.care/skincare/ca/compare/cerave-vs-mesoestetic) - [La Roche-Posay vs A+](https://lovi.care/skincare/ca/compare/la-roche-posay-vs-a) - [La Roche-Posay vs Mesoestetic](https://lovi.care/skincare/ca/compare/la-roche-posay-vs-mesoestetic) - [Dr. Althea vs A+](https://lovi.care/skincare/ca/compare/dr-althea-vs-a) - [Dr. Althea vs Mesoestetic](https://lovi.care/skincare/ca/compare/dr-althea-vs-mesoestetic) - [Some By Mi vs A+](https://lovi.care/skincare/ca/compare/some-by-mi-vs-a) - [Some By Mi vs Mesoestetic](https://lovi.care/skincare/ca/compare/some-by-mi-vs-mesoestetic) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/compare/a-vs-mesoestetic - United Kingdom: https://lovi.care/skincare/uk/compare/a-vs-mesoestetic - Ireland: https://lovi.care/skincare/ie/compare/a-vs-mesoestetic - Germany: https://lovi.care/skincare/de/compare/a-vs-mesoestetic - France: https://lovi.care/skincare/fr/compare/a-vs-mesoestetic - Italy: https://lovi.care/skincare/it/compare/a-vs-mesoestetic - Netherlands: https://lovi.care/skincare/nl/compare/a-vs-mesoestetic - Spain: https://lovi.care/skincare/es/compare/a-vs-mesoestetic - Canada: https://lovi.care/skincare/ca/compare/a-vs-mesoestetic (this page) - Australia: https://lovi.care/skincare/au/compare/a-vs-mesoestetic - Singapore: https://lovi.care/skincare/sg/compare/a-vs-mesoestetic - Saudi Arabia: https://lovi.care/skincare/sa/compare/a-vs-mesoestetic - United Arab Emirates: https://lovi.care/skincare/ae/compare/a-vs-mesoestetic