# ZO Skin Health Growth Factor Serum for skin with dark spots

**Lovi Fit: High fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/au/p/zo-skin-health/growth-factor-serum/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [ZO Skin Health](https://lovi.care/skincare/au/brands/zo-skin-health)
Category: [Serums and treatments](https://lovi.care/skincare/au/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for skin with dark spots.

## Why this fit

- High suitability for your normal skin is provided by glycerin and hydrolyzed sericin, which offer humectant action to maintain hydration, while Buddleja Davidii Meristem Cell Culture and Dipeptide Diaminobutyroyl Benzylamide Diacetate work to smooth texture and minimize fine lines.
- Glycerin and tocopherol offer antioxidant effects and hydration, supporting your goal of addressing pigmentation and maintaining overall skin health.
- The product is safe for your normal skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/zo-skin-health/growth-factor-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/au/p/zo-skin-health/growth-factor-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/au/p/zo-skin-health/growth-factor-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/au/p/zo-skin-health/growth-factor-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/au/p/zo-skin-health/growth-factor-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/au/p/zo-skin-health/growth-factor-serum/for/dark-spots): High (this page)
- [Mature skin](https://lovi.care/skincare/au/p/zo-skin-health/growth-factor-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/au/p/zo-skin-health/growth-factor-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/zo-skin-health/growth-factor-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Dipeptide Diaminobutyroyl Benzylamide Diacetate, Adenosine Triphosphate, Beta-Glucan, Angelica Polymorpha Sinensis Root Extract, Hydrolyzed Sericin

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A novel anti-aging serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide, and laminaria extract significantly increased anti-aging biomarkers and improved static and dynamic wrinkles as well as skin quality in clinical studies. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/))
- A bacterial nanocellulose wound dressing incorporating polyhexamethylene biguanide and sericin showed no skin irritation in healthy volunteers and significantly promoted wound healing with lower wound size and higher collagen formation in full-thickness rat wounds compared to controls. ([Archives of Dermatological Research, 2016](https://pubmed.ncbi.nlm.nih.gov/26796543/))
- The application of a vitamin B12 and adenosine triphosphate complex improved skin radiance, elasticity, and texture in human participants. ([Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/39194754/))
- Direct delivery of intracellular adenosine triphosphate using ATP-encapsulated fusogenic small unilamellar lipid vesicles accelerated wound healing, improved granular tissue development, re-epithelialization, and increased vascular endothelial growth factor expression compared to lipid vesicles alone in adult nude mice. ([American Journal of Surgery, 2007](https://pubmed.ncbi.nlm.nih.gov/17236849/))
- A self-powered chloroplast-driven nanophotosystem consisting of Chlorella-derived nanothylakoid units and hyaluronic acid microneedles increased mitochondrial biogenesis, adenosine triphosphate generation, and NAD(P)H pools in senescent fibroblasts, leading to increased collagen synthesis and alleviated skin photoaging. ([Journal of Nanobiotechnology, 2026](https://pubmed.ncbi.nlm.nih.gov/42144642/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Treatment with topical formulations containing beta-glucan combined with nanofractional radiofrequency plus magnetic nanofractional radiofrequency showed the best efficacy and was tolerable and effective in Chinese women with abdominal stretch marks compared to control groups. ([Dermatology and Therapy, 2023](https://pubmed.ncbi.nlm.nih.gov/37171578/))
- Topical beta-glucan mildly improved striae gravidarum, 1565-nm non-ablative fractional laser showed better results than topical beta-glucan, and the combined strategy further improved striae gravidarum atrophy compared to single treatment. ([The Journal of Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35570397/))
- Angelica sinensis essential oil at 5%-10% demonstrated significant anti-acne effects comparable to adapalene gel with reduced side effects in mice by suppressing Cutibacterium acnes and downregulating IL-1β. ([Journal of Ethnopharmacology, 2026](https://pubmed.ncbi.nlm.nih.gov/41482092/))
- An Angelica sinensis extract containing 1% ligustilide demonstrated anti-inflammatory, antioxidant, anti-senescence, matrix-supportive, and antimicrobial effects in human keratinocytes and dermal fibroblasts. ([Frontiers in Pharmacology, 2026](https://pubmed.ncbi.nlm.nih.gov/41948733/))
- Topical application of Angelica sinensis extract induced noticeable hair regrowth, restored hair shaft lengths and follicle size, and decreased apoptotic cells in C57BL/6 mice. ([The American Journal of Chinese Medicine, 2014](https://pubmed.ncbi.nlm.nih.gov/25004889/))
- Bacterial cellulose wound dressing containing silk sericin and PHMB improved wound quality and reduced pain compared to Bactigras in patients with split-thickness skin graft donor-site wounds. ([Archives of Dermatological Research, 2018](https://pubmed.ncbi.nlm.nih.gov/30302557/))
- Topical application of sericin gels increased skin intrinsic moisturization, hydroxyproline content, and epidermal hydration while decreasing transepidermal water loss and skin impedance in healthy human volunteers. ([Journal of Cosmetic Dermatology, 2005](https://pubmed.ncbi.nlm.nih.gov/17168872/))
- Silk sericin-releasing bacterial nanocellulose gel demonstrated improved mechanical properties, controlled sericin release, non-cytotoxicity on L929 and HaCaT cells, and non-irritancy in subcutaneous tissue compared to a commercially available paper mask. ([BMC Biotechnology, 2014](https://pubmed.ncbi.nlm.nih.gov/25487808/))

## What reviewers say

Based on a very large amount of data, this product is highly regarded by users with aging, dry, and sensitive skin for its hydrating and plumping effects, visibly reducing fine lines. The lightweight gel formula is frequently praised for restoring the skin's moisture barrier and improving texture. However, some users with acne-prone skin report breakouts, and the high price is a common concern.

- Liked: Lightweight gel (mostly mentioned)
- Liked: Hydrating, plumping (often mentioned)
- Disliked: Very expensive (often mentioned)
- Liked: Gentle, soothing (sometimes noted)
- Liked: Reduces lines (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Causes breakouts (rarely noted)
- Disliked: Faulty pump (rarely noted)
- Disliked: Pills under makeup (rarely noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Growth Factor Serum a great fit for skin with dark spots?

Growth Factor Serum is a great fit for skin with dark spots because glycerin and tocopherol help keep skin hydrated while addressing pigmentation. It is safe for your skin with no risks of irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for skin with dark spots?

Glycerin and tocopherol make this serum a good fit for skin with dark spots because they provide hydration and antioxidant effects that help address pigmentation. Glycerin and hydrolyzed sericin also maintain hydration, while dipeptide diaminobutyroyl benzylamide diacetate helps smooth texture.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/)

### What does Dipeptide Diaminobutyroyl Benzylamide Diacetate do for skin with dark spots?

Dipeptide diaminobutyroyl benzylamide diacetate is included in serums that help smooth out texture and improve overall skin quality. However, a product for dark spots needs brightening ingredients like niacinamide or antioxidants to help even out skin tone.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/)

### What does Adenosine Triphosphate do for skin with dark spots?

Adenosine Triphosphate helps support skin with dark spots by providing cellular energy that aids in normal turnover and renewal. A product of this type needs brightening ingredients like vitamin C or niacinamide and gentle exfoliants to effectively fade dark spots.

### Where does this serum go in a skincare routine for skin with dark spots?

This treatment serum goes in your evening routine, applied after cleansing and before your moisturizer. Putting it on at night keeps things simple and gives you extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum alongside retinol by applying the treatment after your retinol or alternating nights to keep skin calm and smooth. Glycerin and tocopherol help maintain hydration and support overall skin health while you use both products.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/)

### How often should I use this serum?

This serum is a great fit for your skin with dark spots and is used in the evening as part of your routine. Glycerin and tocopherol provide hydration and antioxidant benefits to help address pigmentation and keep your skin healthy.

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This serum is unlikely to cause breakouts or clog pores for skin with dark spots because it is free of harsh ingredients that typically trigger irritation. Reviewers rarely report breakouts, and its gentle formula is well suited to maintain overall skin health.
Sources: [Archives of Dermatological Research, 2016](https://pubmed.ncbi.nlm.nih.gov/26796543/)

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum). Oleyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for skin with dark spots

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/au/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dark-spots) — High fit — A$16.95 at Amazon
- [Guerlain Abeille Royale Double R Renew & Repair Serum](https://lovi.care/skincare/au/p/guerlain/abeille-royale-double-r-renew-and-repair-advanced-serum/for/dark-spots) — High fit — A$210.41 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/au/p/la-mer/the-regenerating-serum/for/dark-spots) — High fit — A$740.13 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/au/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — A$13.99 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/au/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — A$23.99 at Amazon
- Moisturizer: [Isntree Green Tea Fresh Serum](https://lovi.care/skincare/au/p/isntree/green-tea-fresh-serum/for/dark-spots) — Superior fit — A$34.00 at Amazon

## Where to buy

- Amazon.com.au: A$245.42 (https://www.amazon.com.au/dp/B00FSBMJHI?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Cyclopentasiloxane, Dipropylene Glycol, Propylene Glycol, Dimethicone, Glycerin, Dimethicone Crosspolymer, Dimethicone Peg-10 15 Crosspolymer, Peg-12 Dimethicone Crosspolymer, Butylene Glycol, Dimethicone Vinyl Dimethicone Crosspolymer, Sodium Phosphate, Panthenyl Triacetate, Magnesium Sulfate, Hydrolyzed Sericin, Ethyl Linoleate, Buddleja Davidii Meristem Cell Culture, Angelica Polymorpha Sinensis Root Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Lactobacillus Panax Ginseng Root Extract Ferment Filtrate, Disodium Acetyl Glucosamine Phosphate, Acetyl Tyrosine, Dimethiconol, Oleyl Alcohol, Proline, Parfum, Tocopherol, Beta-Glucan, Adenosine Triphosphate, Hydrolyzed Protein, Sodium Chloride, Xanthan Gum, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/zo-skin-health/growth-factor-serum/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/zo-skin-health/growth-factor-serum/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/zo-skin-health/growth-factor-serum/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/zo-skin-health/growth-factor-serum/for/dark-spots
- France: https://lovi.care/skincare/fr/p/zo-skin-health/growth-factor-serum/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/zo-skin-health/growth-factor-serum/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/zo-skin-health/growth-factor-serum/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/zo-skin-health/growth-factor-serum/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/zo-skin-health/growth-factor-serum/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/zo-skin-health/growth-factor-serum/for/dark-spots (this page)
- Singapore: https://lovi.care/skincare/sg/p/zo-skin-health/growth-factor-serum/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/zo-skin-health/growth-factor-serum/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/zo-skin-health/growth-factor-serum/for/dark-spots