# Youth To The People Polypeptide-121 Future Cream for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: Average · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/au/p/youth-to-the-people/polypeptide-121-future-cream/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [Youth To The People](https://lovi.care/skincare/au/brands/youth-to-the-people)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/au/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few moisturizers fit it even better.

## Why this fit

- Offers excellent moisturizing and skin-smoothing benefits for your combination skin, as hydrolyzed hyaluronic acid and niacinamide hydrate and improve skin texture. Panthenol and niacinamide also support your skin barrier function and reduce inflammation, making it relevant for your acne, blemishes, and breakouts.
- The inclusion of aloe barbadensis leaf juice and bisabolol ensures a gentle experience, minimizing the risk of irritation for your acne-prone skin.
- This formula is safe for your skin, containing no harsh ingredients and featuring soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/youth-to-the-people/polypeptide-121-future-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/au/p/youth-to-the-people/polypeptide-121-future-cream/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/au/p/youth-to-the-people/polypeptide-121-future-cream/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/au/p/youth-to-the-people/polypeptide-121-future-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/au/p/youth-to-the-people/polypeptide-121-future-cream/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/au/p/youth-to-the-people/polypeptide-121-future-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/au/p/youth-to-the-people/polypeptide-121-future-cream/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/au/p/youth-to-the-people/polypeptide-121-future-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/youth-to-the-people/polypeptide-121-future-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Biotech Collagen, Hydrolyzed Hyaluronic Acid, Niacinamide, Acetyl Tetrapeptides, Aloe Barbadensis Leaf Juice

## What the research says

- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief. ([Plastic and Reconstructive Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29649056/))
- Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo. ([Journal of Alternative and Complementary Medicine, 2010](https://pubmed.ncbi.nlm.nih.gov/20569031/))
- Formulations containing 0.10%, 0.25%, and 0.50% freeze-dried Aloe vera extract increased stratum corneum water content compared with the vehicle in 20 female subjects, while transepidermal water loss was not modified. ([Skin Research and Technology, 2006](https://pubmed.ncbi.nlm.nih.gov/17026654/))

## What reviewers say

Based on a very large amount of data, users with dry and sensitive skin frequently praise this cream for its ability to provide deep, long-lasting hydration without feeling heavy, often describing a "dewy" and "plump" finish. Many appreciate its barrier-strengthening ingredients and lightweight texture under makeup. Some users with oily or acne-prone skin experienced breakouts, and others found the price point too high for the amount of product provided.

- Liked: Deep hydration (mostly mentioned)
- Liked: Lightweight texture (mostly mentioned)
- Liked: Makeup compatibility (often mentioned)
- Disliked: Expensive for size (often mentioned)
- Liked: Soothing formula (sometimes noted)
- Disliked: Unpleasant scent (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Unhygienic packaging (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Youth To The People Polypeptide-121 Future Cream a great fit for acne-prone skin?

This cream is a great fit because ingredients like hydrolyzed hyaluronic acid and niacinamide hydrate your skin and improve its texture. Panthenol and niacinamide also support your skin barrier and calm breakouts, while aloe and bisabolol help keep the formula gentle and unlikely to irritate your skin.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which ingredients make this cream a good fit for acne-prone skin?

Niacinamide, panthenol, aloe barbadensis leaf juice, and bisabolol make this cream a great fit for acne-prone skin by soothing the skin, reducing blemishes, and minimizing the risk of irritation. Hydrolyzed hyaluronic acid also helps hydrate the skin while keeping the formula gentle.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What does Biotech Collagen do for acne-prone skin?

Biotech Collagen helps keep acne-prone skin soft and smooth without feeling heavy or greasy. It supports skin recovery and helps maintain moisture balance, which is especially useful when using strong blemish treatments.

### What does Hydrolyzed Hyaluronic Acid do for acne-prone skin?

Hydrolyzed hyaluronic acid helps balance moisture in acne-prone skin while supporting a calm, clear complexion. Depending on its molecular weight and formulation, it may help manage skin oil production and inflammation safely.
Sources: [RSC Advances, 2026](https://pubmed.ncbi.nlm.nih.gov/41659329/)

### Where does it go in a skincare routine for acne-prone skin?

This moisturizing treatment goes after your hydrating toner in the morning and after your treatment step in the evening. It helps keep your skin soft and calm while reducing breakouts.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Can I use this cream with retinol, and in what order?

Yes, you can use this cream with retinol, and applying it right before your retinol may help reduce dryness and irritation. This formula contains soothing ingredients and barrier-supporting components that make it safe and gentle for your skin when combining treatments.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### How often should I use it?

This moisturizing treatment is a great fit for your acne-prone skin and is generally safe for daily use. Applying it twice a day helps keep your skin hydrated and supports your skin barrier.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for acne-prone skin?

This cream is a great fit and is unlikely to clog pores or cause breakouts for your acne-prone skin because it contains soothing ingredients like aloe barbadensis leaf juice and bisabolol that keep irritation low. Niacinamide and panthenol also help reduce inflammation and support your skin barrier, while reviewers rarely report breakouts.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Can I use it around the eyes or on my body?

You can safely use this moisturizing treatment around your eyes and on your body because its gentle formula features soothing components and has an excellent safety profile. It helps hydrate and keep skin smooth, though the skin around the eyes is much thinner than body skin and may need extra care.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (benzyl alcohol). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for acne-prone skin

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/au/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — A$24.00 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/au/p/cosrx/advanced-snail-96-mucin-power-essence/for/acne-prone-skin) — Superior fit — A$18.90 at Amazon
- [belif The True Cream Aqua Bomb](https://lovi.care/skincare/au/p/belif/the-true-cream-aqua-bomb/for/acne-prone-skin) — High fit — A$50.56 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/au/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — A$13.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/au/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — A$34.66 at Amazon
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/au/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/acne-prone-skin) — Superior fit — A$80.43 at Amazon

## Where to buy

No store in Australia has a checked price for this product, so the page shows none.

## Ingredients

Water, Dicaprylyl Carbonate, Hydrolyzed Hyaluronic Acid, Trimethylolpropane Tricaprylate Tricaprate, Tridecyl Trimellitate, Propanediol, Sh-Polypeptide-121, Polyglyceryl-3 Methylglucose Distearate, Panthenol, Niacinamide, Proline, Tocopheryl Acetate, Aloe Barbadensis Leaf Juice, Hydrolyzed Cannabis Sativa Seed Extract Cannabis Sativa Seed Extract, Hydrolyzed Rice Protein, Hydrolyzed Pea Protein, Salvia Hispanica Seed Extract, Acetyl Tetrapeptide-11, Acetyl Tetrapeptide-9, Acetyl Tetrapeptide-2, Hibiscus Sabdariffa Fruit Extract, Ammonium Acryloyldimethyltaurate Beheneth-25 Methacrylate Crosspolymer, Hydrolyzed Linseed Seed, Castor Ipdi Copolymer Oil, Ceramide Ap, Ceramide Np, Cetearyl Alcohol, Cetearyl Glucoside, Glycerin, Hydrolyzed Sodium Hyaluronate, Coco-Caprylate Caprate, Dilinoleic Acid Propanediol Pdi Crosspolymer, Benzyl Alcohol, Zingiber Officinale Root Extract, Bisabolol, Caprylyl Glycol, Carbomer, Dimethyl Isosorbide, Dipropylene Glycol, Erythritol, Ethylhexylglycerin, Glucose, 1,2-Hexanediol, Trisodium Ethylenediamine Disuccinate, Glyceryl Monostearate, Phytosphingosine, Polyacrylate Crosspolymer-6, Polysorbate 20, Caprylhydroxamic Acid, Potassium Sorbate, Glycine, Hydroxyacetophenone, Sodium Benzoate, T-Buty Alcohol, Citric Acid, Sodium Citrate, Sodium Lactate, Triheptanoin, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/youth-to-the-people/polypeptide-121-future-cream/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/youth-to-the-people/polypeptide-121-future-cream/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/youth-to-the-people/polypeptide-121-future-cream/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/youth-to-the-people/polypeptide-121-future-cream/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/youth-to-the-people/polypeptide-121-future-cream/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/youth-to-the-people/polypeptide-121-future-cream/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/youth-to-the-people/polypeptide-121-future-cream/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/youth-to-the-people/polypeptide-121-future-cream/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/youth-to-the-people/polypeptide-121-future-cream/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/youth-to-the-people/polypeptide-121-future-cream/for/acne-prone-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/youth-to-the-people/polypeptide-121-future-cream/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/youth-to-the-people/polypeptide-121-future-cream/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/youth-to-the-people/polypeptide-121-future-cream/for/acne-prone-skin