# The Ordinary Multi-Peptide + HA Serum for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/au/p/the-ordinary/multi-peptide-ha-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [The Ordinary](https://lovi.care/skincare/au/brands/the-ordinary)
Category: [Serums and treatments](https://lovi.care/skincare/au/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- This serum offers excellent plumping and firming for your combination skin due to multiple peptides like Acetyl Hexapeptide-8 and Palmitoyl Tripeptide-1, which work synergistically with hydrating ingredients such as Sodium Hyaluronate Crosspolymer to enhance skin's moisture barrier and provide a smoother appearance.
- While the formula provides general hydration and barrier support beneficial for combination skin, its primary focus is not on addressing your specific concerns of acne, blemishes, and breakouts.
- The product is safe for your skin, containing soothing ingredients like Allantoin and Glycerin, and lacks any harsh or prohibited substances that could cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/the-ordinary/multi-peptide-ha-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/au/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/au/p/the-ordinary/multi-peptide-ha-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/au/p/the-ordinary/multi-peptide-ha-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/au/p/the-ordinary/multi-peptide-ha-serum/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/au/p/the-ordinary/multi-peptide-ha-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/au/p/the-ordinary/multi-peptide-ha-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/au/p/the-ordinary/multi-peptide-ha-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/the-ordinary/multi-peptide-ha-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Multi-Peptides, Sodium Hyaluronate, Lactococcus Lysate Ferment, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1

## What the research says

- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))

## What reviewers say

Based on a very large amount of data, users with dry, mature, or dehydrated skin frequently praise this serum for its ability to plump the skin and smooth texture, often noting a reduction in fine dehydration lines. While many appreciate it as an affordable "all-in-one" anti-aging solution, a minority of users report breakouts or a lack of visible results regarding deeper wrinkles.

- Liked: Deeply hydrates (mostly mentioned)
- Liked: Great value (often mentioned)
- Liked: Smooths texture (often mentioned)
- Liked: Plumps and firms (sometimes noted)
- Liked: Reduces fine lines (sometimes noted)
- Disliked: Conflicts with actives (sometimes noted)
- Disliked: Unclear results (sometimes noted)
- Disliked: Allergic reactions (rarely noted)
- Disliked: Causes breakouts (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes The Ordinary Multi-Peptide + HA Serum a great fit for acne-prone skin?

This serum is a great fit because it has a very safe and gentle formula with soothing ingredients like allantoin and glycerin that are unlikely to cause irritation. It helps keep skin calm and hydrated, though it does not focus directly on treating breakouts.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for acne-prone skin?

This serum is a good fit because it includes soothing ingredients like Allantoin and Glycerin, which help calm the skin and are unlikely to cause irritation.

### What do Peptides do for acne-prone skin?

Peptides help acne-prone skin by fighting acne-causing bacteria and calming redness and swelling. They may also support the skin barrier, which is often delicate when you deal with breakouts.
Sources: [Biochemical Pharmacology, 2025](https://pubmed.ncbi.nlm.nih.gov/39662606/), [Antibiotics, 2020](https://pubmed.ncbi.nlm.nih.gov/31940992/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Where does it go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing, as suggested for simplicity and extra safety. It is safe for your skin with soothing ingredients like allantoin and glycerin, though its primary focus is not on addressing acne or breakouts.

### Can I use this serum with retinol, and in what order?

You can use this serum alongside a retinol, applying the serum first to clean skin and following with your retinol once it absorbs. This approach helps keep your skin hydrated while you use retinol, and it is unlikely to cause irritation because the formula includes soothing ingredients like glycerin and allantoin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use it?

You can use this treatment in the evening as part of your routine. It is safe for daily use, helping to keep your skin hydrated and smooth while lowering the risk of irritation.
Sources: [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can it clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to clog pores or cause breakouts on acne-prone skin, as it contains soothing ingredients like allantoin and lacks harsh substances that trigger irritation. Reviewers rarely report breakouts from using this formula, and its safety profile suggests good suitability for keeping skin calm.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/au/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — A$16.95 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/au/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — A$52.32 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/au/p/neogen-dermalogy/real-vitamin-c-serum/for/acne-prone-skin) — Superior fit — A$50.60 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/au/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — A$13.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/au/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — A$34.66 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/au/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — A$24.00 at Amazon

## Where to buy

- Amazon.com.au: A$29.90 (https://www.amazon.com.au/dp/B0BLHW7JZM?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Glycerin, Lactococcus Lysate Ferment, Acetyl Hexapeptide-8, Pentapeptide-18, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-38, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetylarginyltryptophyl Diphenylglycine, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Allantoin, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Arginine, Aspartic Acid, Trehalose, Fructose, Glucose, Maltose, Urea, Sodium Pca, Pca, Sodium Lactate, Citric Acid, Hydroxypropyl Cyclodextrin, Sodium Chloride, Sodium Hydroxide, Butylene Glycol, Pentylene Glycol, Acacia Senegal Gum, Xanthan Gum, Carbomer, Polysorbate 20, Ppg-26-Buteth-26, Peg-40 Hydrogenated Castor Oil, Trisodium Ethylenediamine Disuccinate, Ethoxydiglycol, Sodium Benzoate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/the-ordinary/multi-peptide-ha-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/the-ordinary/multi-peptide-ha-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/the-ordinary/multi-peptide-ha-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/the-ordinary/multi-peptide-ha-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/the-ordinary/multi-peptide-ha-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/the-ordinary/multi-peptide-ha-serum/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/the-ordinary/multi-peptide-ha-serum/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/the-ordinary/multi-peptide-ha-serum/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/the-ordinary/multi-peptide-ha-serum/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/the-ordinary/multi-peptide-ha-serum/for/acne-prone-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-ha-serum/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/the-ordinary/multi-peptide-ha-serum/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/the-ordinary/multi-peptide-ha-serum/for/acne-prone-skin