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Soolantra Cream for acne-prone skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Soolantra Cream

Average

  • AverageCombination Skin Fit
  • AverageEffectiveness
  • HighSafety

Works for acne-prone skin; other serums fit it better.

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate treatment for inflammatory lesions due to ivermectin, which helps reduce inflammation and kill mites, but lacks specialized ingredients to effectively target your acne, blemishes, and breakouts.
  • Glycerin provides hydration suitable for combination skin, though it does not offer sufficient oil control for your oilier areas.
  • The product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

How to apply

  • Use your serum as part of your PM routine and start 3x/week before working up to daily use.
  • Apply this treatment after cleansing and toner, and before your moisturizer.
  • Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
  • Apply the product on clean, dry skin to help manage your breakouts safely.
  • Avoid the eye area and do a patch test before your first use.

People Say

★4.1Overall rating based on 500+ reviews

A notable portion of users experience an initial worsening of their skin, including breakouts and irritation, during the first few weeks of use before seeing improvements, indicating a need for patience.

Highlights

  • Clears pustules Mostly Mentioned
    • “Cleared all lumps and bumps”
    • “Pustules diminishing after 3 weeks”
    • “Acne-type bumps completely gone”
    • “No new pustules formed”
  • Life-changing results Often Mentioned
    • “Regained my self-confidence”
    • “Best thing I have ever tried”
    • “Miracle cream for my face”
    • “Wish I found this years ago”
  • Reduces redness Often Mentioned
    • “Calming redness significantly”
    • “Redness reduced by 90%”
    • “Skin tone is finally even”
    • “Helps with persistent flushing”
  • Initial flare-up Often Mentioned
    • “Got worse before getting better”
    • “Terrible breakout in first week”
    • “Face erupted with whiteheads initially”
    • “Skin looked awful for two weeks”
  • Improves texture Sometimes Noted
    • “Skin feels baby soft”
    • “Smoother than it has ever been”
    • “Eliminated scabby, peeling skin”
    • “Rough patches smoothed out”
  • High cost Sometimes Noted
    • “Very expensive without insurance”
    • “Price is too high”
    • “Insurance declined coverage”
    • “Cost is a major downside”
  • Slow onset Sometimes Noted
    • “Took 3 months to see results”
    • “Requires patience, not overnight”
    • “Slow process to clear skin”
    • “Didn't work until week 12”
  • Burning or itching Rarely Noted
    • “Mild burning upon application”
    • “Skin felt itchy and irritated”
    • “Stinging sensation for first few days”
    • “Face hurt when touched”

Sources: lovi.care, drugs.com, webmd.com, theindependentpharmacy.co.uk, doctorfox.co.uk, and more

Questions and answers

How well does Soolantra Cream work for acne-prone skin?

Soolantra Cream is an average fit for acne-prone skin because it offers moderate treatment for redness and bumps using ivermectin, but lacks specialized ingredients to effectively target breakouts and oiliness. Treatments that fit this skin better need ingredients like niacinamide, zinc PCA, and propolis to control oil and clear blemishes while keeping the skin balanced.

Which ingredients make this cream a good fit for acne-prone skin?

Soolantra Cream is an average fit for acne-prone skin because ivermectin helps calm inflammation and glycerin provides soft hydration, though it lacks oil control. Acne-prone skin needs ingredients like niacinamide, propolis, and zinc PCA to target breakouts and balance oil without irritation.

Clinical, Cosmetic and Investigational Dermatology, 2017

What does Glycerin do for acne-prone skin?

Glycerin helps keep acne-prone skin hydrated and calm without clogging pores or feeling heavy. It supports the skin barrier so it stays soft and smooth while handling everyday treatments.

The British Journal of Dermatology, 2008International Journal of Toxicology, 2019

Where does this cream go in a skincare routine for acne-prone skin?

Apply this treatment in the evening after your cleansing toner and before your moisturizer. Acne-prone skin works best with products that control oil and target breakouts with specialized ingredients.

Can I use this cream with retinol, and in what order?

You can use this treatment with retinol, but apply your retinol first and follow with this cream in your evening routine. This cream is safe for your skin with no risk of irritation from harsh ingredients.

How often should I use this cream?

You can use this treatment in your evening routine. It helps reduce inflammation, though acne-prone skin also needs specialized ingredients to clear breakouts and oil control for oilier areas.

Can this cream clog pores, cause breakouts or purging for acne-prone skin?

This cream is unlikely to irritate acne-prone skin, but it may cause an initial flare-up for some users. While it helps calm redness and inflammation with ivermectin, it lacks the specialized ingredients needed to effectively target breakouts and blemishes. Acne-prone skin needs products containing ingredients like salicylic acid or benzoyl peroxide to clear pores and control oil.

Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol, stearyl alcohol, and oleyl alcohol are fatty alcohols, which soften the skin.

What the research says

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • A soap-free cleansing lotion containing cetyl alcohol and sodium cocoyl apple amino acids reduced skin surface impurities and improved skin hydration, barrier function, and skin tone in 27 healthy adult subjects over 30 days.

    Cureus, 2025

  • The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

    Journal of Cosmetic Dermatology, 2020

  • Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

    International Journal of Cosmetic Science, 2001

  • Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

    Journal of Drugs in Dermatology, 2012

  • Wearing an N95 mask alone compared to using dimethicone cream or hydrocolloid dressing caused more adverse skin reactions among 73 military health care workers, with no significant differences in fit test failure rates between groups.

    Military Medicine, 2024

  • A dimethicone skin protectant lotion significantly decreased visual scoring and transepidermal water loss compared to vehicle control and SLS-only treated sites in 12 healthy humans exposed to sodium lauryl sulfate.

    Skin Research and Technology, 2000

  • Treatment with a moisturizer containing dimethicone and glycerine increased epidermal thickness by 0.019 mm, improved barrier function by decreasing transepidermal water loss by 13%, decreased melanin intensity, and induced keratins 6 and 16 in fifteen women with moderately photoaged forearms.

    Clinical and Experimental Dermatology, 2007

  • Topical chloramphenicol-betamethasone combined with sodium hyaluronate/trehalose/carbomer gel compared to chloramphenicol-betamethasone alone reduced most subjective symptoms at 1 week but increased blurred vision at 4 weeks following strabismus surgery in 31 patients, with no significant differences in conjunctival inflammation between treatments.

    Journal of Ocular Pharmacology and Therapeutics, 2019

  • Incorporating nanoemulsions into hydrogels with increasing Carbopol 934 proportions from 1% to 3% progressively decreased the percutaneous flux rates of terbinafine and citral, increased drug accumulation in the stratum corneum while decreasing it in the epidermis/dermis compared to nanoemulsions alone, and shifted delivery routes from skin appendages to intercellular paths.

    International Journal of Nanomedicine, 2016

  • Topical liquiritin carbomer gel treatment restored skin barrier function, increased barrier proteins and antioxidant enzymes, and decreased inflammatory cytokines and oxidative stress in a mouse model of glucocorticoid-induced skin inflammation.

    Pharmaceutics, 2024

Why other serums fit acne-prone skin better

Ingredients

Ivermectin, Glycerin, Isopropyl Palmitate, Carbomer, Dimethicone, Disodium Edta, Citric Acid, Cetyl Alcohol, Stearyl Alcohol, Sorbitan Stearate, Methyl Parahydroxybenzoate, Propyl Parahydroxybenzoate, Phenoxyethanol, Propylene Glycol, Oleyl Alcohol, Sodium Hydroxide, Water

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play