# SkinCeuticals P-TOX for dry skin

**Lovi Fit: High fit for dry skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/au/p/skinceuticals/p-tox/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [SkinCeuticals](https://lovi.care/skincare/au/brands/skinceuticals)
Category: [Serums and treatments](https://lovi.care/skincare/au/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry skin; a few serums fit it even better.

## Why this fit

- Offers high suitability for your dry skin as the Advanced Peptide Complex and Hexapeptide stimulate collagen and repair your skin barrier, addressing dryness and flakiness. Niacinamide further supports barrier function and soothes irritation.
- The Dipeptide and Pha contribute to excellent plumping and firming effects, enhancing visible anti-aging benefits for your skin.
- The formula is safe for your dry skin, containing no harsh ingredients and including soothing components like Niacinamide.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/skinceuticals/p-tox/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/au/p/skinceuticals/p-tox/for/dry-skin): High (this page)
- [Combination skin](https://lovi.care/skincare/au/p/skinceuticals/p-tox/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/au/p/skinceuticals/p-tox/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/au/p/skinceuticals/p-tox/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/au/p/skinceuticals/p-tox/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/au/p/skinceuticals/p-tox/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/au/p/skinceuticals/p-tox/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/skinceuticals/p-tox/for/oily-acne-prone-skin): High

## Key ingredients

Advanced Peptide Complex, Hexapeptide, Niacinamide, Laminaria Digitata Extract

## What the research says

- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- A peptide complex stimulated basement membrane protein expressions and significantly improved skin wrinkles at all five measured sites after two weeks in 22 healthy Asian female volunteers older than 40 years. ([International Journal of Molecular Sciences, 2019](https://pubmed.ncbi.nlm.nih.gov/31861912/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Postresurfacing use of a tripeptide/hexapeptide system improved healing, reduced erythema, exudation, tenderness, and burning/stinging, and increased subject satisfaction compared to a bland ointment and cream in 14 female subjects following facial laser resurfacing. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28371204/))
- Adding a tripeptide/hexapeptide anhydrous gel pre- and post-procedure to a topical body treatment significantly reduced patient-reported scores of skin edema, induration, and subcutaneous fibrous banding compared to the body treatment alone in 10 female patients undergoing neck and body contouring procedures. ([Aesthetic Surgery Journal. Open Forum, 2021](https://pubmed.ncbi.nlm.nih.gov/33791673/))
- Topical tripeptide/hexapeptide formulations (RSN and TFB) applied around medial thigh liposuction accelerated healing, reduced induration, edema, and fluid infiltration, and improved extracellular matrix remodeling compared to a bland moisturizer. ([Aesthetic Surgery Journal. Open Forum, 2021](https://pubmed.ncbi.nlm.nih.gov/33791675/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- A skincare regimen containing Macrocystis pyrifera ferment consisting of a cleansing foam, a serum, and a moisturizer decreases the visible effects of inflammation and aging while promoting healing and improving patient satisfaction. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38922798/))
- Macrocystis pyrifera ferment-containing creams decrease visible inflammation and signs of aging while enhancing barrier resilience and recovery. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/38041526/))
- Aqueous extracts from Macrocystis pyrifera and Durvillaea antarctica exhibited antiviral activity against acyclovir-sensitive and acyclovir-resistant HSV-1 and HSV-2, and topical formulations significantly reduced the severity and duration of HSV-1 skin lesions in an animal model compared to mock treatment and acyclovir. ([Frontiers in Microbiology, 2020](https://pubmed.ncbi.nlm.nih.gov/33013743/))

## What reviewers say

Based on a very large amount of data, this anti-aging peptide serum and cream duo is highly rated for targeting expression lines, deep-set wrinkles, and uneven skin texture. Users frequently report achieving a radiant, smooth, and hydrated complexion. Some users note that it may take time to see results on deeper wrinkles, and a few experienced breakouts. The high price point is also a common consideration.

- Liked: Smoother skin (mostly mentioned)
- Liked: Hydrating and light (often mentioned)
- Liked: Reduces lines (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Complements Botox (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Causes breakouts (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes SkinCeuticals P-TOX a great fit for dry skin?

SkinCeuticals P-TOX is a great fit because its Advanced Peptide Complex and Hexapeptide stimulate collagen and repair your skin barrier, which addresses dryness and flakiness. Niacinamide further supports barrier function and soothes irritation, while the Dipeptide and PHA provide great plumping and firming effects.
Sources: [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/), [International Journal of Molecular Sciences, 2019](https://pubmed.ncbi.nlm.nih.gov/31861912/)

### Which ingredients make this treatment a good fit for dry skin?

Advanced Peptide Complex, Hexapeptide, and Niacinamide make this treatment a great fit for your dry skin by stimulating collagen, repairing your skin barrier, and soothing irritation. Laminaria Digitata Extract further helps address dryness and flakiness while keeping your skin feeling soft and smooth.
Sources: [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/), [International Journal of Molecular Sciences, 2019](https://pubmed.ncbi.nlm.nih.gov/31861912/)

### What does Peptide Complex do for dry skin?

A peptide complex helps smooth out skin wrinkles and supports your skin when it is dry. This type of product needs nourishing ingredients and moisture-locking components to help repair and hydrate dry skin effectively.
Sources: [International Journal of Molecular Sciences, 2019](https://pubmed.ncbi.nlm.nih.gov/31861912/)

### What does Hexapeptide do for dry skin?

Hexapeptide helps hydrate dry skin and smooth out fine lines when you use it regularly in your routine. It also improves skin elasticity so your face feels softer and looks firmer.
Sources: [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/40565185/)

### Where does this treatment go in a skincare routine for dry skin?

This treatment goes in the evening routine for dry skin after cleansing and before your moisturizer. Applying treatments at night helps support your skin barrier while keeping things simple and safe around sun exposure.

### Can I use it with retinol, and in what order?

You can use this treatment with retinol by applying your retinol first and following with this formula in your evening routine. This helps keep your dry skin comfortable while delivering the smoothing and firming benefits of the Advanced Peptide Complex and Hexapeptide.
Sources: [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/), [International Journal of Molecular Sciences, 2019](https://pubmed.ncbi.nlm.nih.gov/31861912/)

### How often should I use it?

Use this treatment in the evening as part of your routine, applying it after cleansing and before your moisturizer. This timing keeps your routine simple and adds extra safety around sun exposure.

### Can this treatment clog pores, cause breakouts or purging for dry skin?

This treatment is unlikely to cause breakouts for dry skin as it contains no harsh ingredients and features soothing Niacinamide to keep skin calm.

## Alternatives for dry skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/au/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-skin) — Superior fit — A$16.95 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/au/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — A$29.00 at Amazon
- [KraveBeauty Great Barrier Relief](https://lovi.care/skincare/au/p/kravebeauty/great-barrier-relief/for/dry-skin) — Superior fit — A$75.11 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/au/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — A$26.59 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/au/p/pyunkang-yul/calming-deep-moisture-toner/for/dry-skin) — Superior fit — A$23.99 at Amazon
- Moisturizer: [d'Alba First Spray Serum](https://lovi.care/skincare/au/p/d-alba/first-spray-serum/for/dry-skin) — Superior fit — A$26.09 at Amazon

## Where to buy

No store in Australia has a checked price for this product, so the page shows none.

## Ingredients

Advanced Peptide Complex, Hexapeptide, Dipeptide, Pha, Niacinamide, Laminaria Digitata Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skinceuticals/p-tox/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/skinceuticals/p-tox/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/skinceuticals/p-tox/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/skinceuticals/p-tox/for/dry-skin
- France: https://lovi.care/skincare/fr/p/skinceuticals/p-tox/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/skinceuticals/p-tox/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/skinceuticals/p-tox/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/skinceuticals/p-tox/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/skinceuticals/p-tox/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/skinceuticals/p-tox/for/dry-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/skinceuticals/p-tox/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/skinceuticals/p-tox/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skinceuticals/p-tox/for/dry-skin