# Sesderma Azelac RU Serum for skin with dark spots

**Lovi Fit: High fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/au/p/sesderma/azelac-ru-serum/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [Sesderma](https://lovi.care/skincare/au/brands/sesderma)
Category: [Serums and treatments](https://lovi.care/skincare/au/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for skin with dark spots.

## Why this fit

- Highly suitable for your normal skin, this serum effectively targets pigmentation with 4-butylresorcinol and azelaic acid, which inhibit melanin production and promote cell turnover.
- Retinol and niacinamide further enhance skin tone and texture, offering mild exfoliation and supporting overall skin health.
- The formula is safe for your skin, containing no harsh ingredients and posing no risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/sesderma/azelac-ru-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/au/p/sesderma/azelac-ru-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/au/p/sesderma/azelac-ru-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/au/p/sesderma/azelac-ru-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/au/p/sesderma/azelac-ru-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/au/p/sesderma/azelac-ru-serum/for/dark-spots): High (this page)
- [Mature skin](https://lovi.care/skincare/au/p/sesderma/azelac-ru-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/au/p/sesderma/azelac-ru-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/sesderma/azelac-ru-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Liposomal Azelaic Acid, 4-Butylresorcinol, Tranexamic Acid, Niacinamide, Retinol

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Azelaic acid nanocrystal hydrogel 10% achieved a higher success rate and greater lesion reduction than azelaic acid cream 20% in patients with mild to moderate facial acne. ([Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/))
- Application of 15% azelaic acid gel significantly reduced post-inflammatory erythema and hyperpigmentation, decreased hemoglobin and melanin content, improved quality of life, and contributed to acne improvement in patients with mild to moderate acne compared to placebo. ([Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/))
- Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2023](https://pubmed.ncbi.nlm.nih.gov/36729399/))
- The 4-n-butylresorcinol dissolving microneedle patch demonstrated safety and was more than two times more effective than the control patch in skin depigmentation among 45 subjects over 8 weeks. ([Journal of Cosmetic Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/26341915/))
- 4-n-butylresorcinol inhibits human tyrosinase and melanin production more potently than hydroquinone, arbutin, and kojic acid, and visibly reduces age spots within 8 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2013](https://pubmed.ncbi.nlm.nih.gov/23205541/))
- Combined application of dissolving microneedle patches on serum-treated skin successfully delivered more 4-n-butylresorcinol and showed higher efficacy in reducing patients' melanin index and hyperpigmented regions compared to traditional DMN-only and serum-only applications. ([Molecular Pharmaceutics, 2017](https://pubmed.ncbi.nlm.nih.gov/28447799/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))

## What reviewers say

Users report this serum effectively brightens the complexion and fades post-acne marks and sunspots, often showing visible results within a few weeks. It is praised for its lightweight texture and ability to control mild acne, though some users note it requires patience for older, deeper pigmentation and can be slightly drying.

- Liked: Fades dark spots (mostly mentioned)
- Liked: Brightens skin tone (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Disliked: High price (often mentioned)
- Liked: Controls acne (sometimes noted)
- Liked: Gentle on skin (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Drying effect (rarely noted)
- Disliked: Sticky finish (rarely noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Sesderma Azelac RU a great fit for skin with dark spots?

Sesderma Azelac RU Serum is a great fit because it targets dark spots with 4-butylresorcinol and azelaic acid to slow down pigment production and help renew skin cells. Ingredients like retinol and niacinamide also improve skin tone and texture, and the formula is safe and unlikely to cause irritation.

### Which ingredients make this serum a good fit for skin with dark spots?

This serum is a great fit for skin with dark spots because it contains 4-Butylresorcinol, Liposomal Azelaic Acid, Tranexamic Acid, Niacinamide, and Retinol. These ingredients help slow down pigment production, gently smooth the skin surface, and improve overall tone safely.

### What does Azelaic Acid do for skin with dark spots?

Azelaic acid helps fade dark spots and uneven pigmentation by calming inflammation and targeting the overactive pigment cells in the skin. Regular use may visibly clear stubborn spots and improve overall skin tone with a low risk of irritation.
Sources: [Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/21637899/)

### What does 4-Butylresorcinol do for skin with dark spots?

4-Butylresorcinol helps fade dark spots by blocking the enzyme that makes skin pigment, visibly reducing spots within eight weeks. It has a safe profile and is unlikely to cause adverse reactions when used as directed.
Sources: [Journal of the European Academy of Dermatology and Venereology, 2013](https://pubmed.ncbi.nlm.nih.gov/23205541/)

### Where does this serum go in a skincare routine for skin with dark spots?

This serum goes in the evening routine after cleansing and toning, helping to fade dark spots safely.

### Can I use this serum with AHA, and in what order?

You can use this serum with AHAs, but it is best to apply AHAs and this treatment on alternating nights to prevent over-exfoliation and irritation. Because this formula contains retinol and other active ingredients, spacing them out helps keep your skin calm and smooth.

### How often should I use this serum?

Apply this serum in your evening routine, using it once a week at first and gradually increasing frequency if your skin tolerates it well. This gradual approach helps your skin adjust to the active ingredients while minimizing the likelihood of irritation.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This serum is unlikely to clog pores or cause breakouts for skin with dark spots because it has a safe formula with no harsh ingredients. The included retinol gently encourages skin cell turnover, which may occasionally lead to very mild temporary purging as your skin adjusts.

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (parfum) and drying alcohol (alcohol).

## Alternatives for skin with dark spots

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/au/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dark-spots) — High fit — A$16.95 at Amazon
- [Guerlain Abeille Royale Double R Renew & Repair Serum](https://lovi.care/skincare/au/p/guerlain/abeille-royale-double-r-renew-and-repair-advanced-serum/for/dark-spots) — High fit — A$210.41 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/au/p/la-mer/the-regenerating-serum/for/dark-spots) — High fit — A$740.13 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/au/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — A$13.99 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/au/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — A$23.99 at Amazon
- Moisturizer: [Isntree Green Tea Fresh Serum](https://lovi.care/skincare/au/p/isntree/green-tea-fresh-serum/for/dark-spots) — Superior fit — A$34.00 at Amazon

## Where to buy

- Amazon.com.au: A$93.50 (https://www.amazon.com.au/dp/B07S5CRSN4?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)
Prices checked 31 Oct 2026.

## Ingredients

Water, Propylene Glycol, Alcohol, Peg Ppg-20 6 Dimethicone, Polymethyl Methacrylate, Peg-40 Hydrogenated Castor Oil, 4-Butylresorcinol, Azelaic Acid, Retinol, Ascorbyl Glucoside, Niacin, Undecylenoyl Phenylalanine, Glycyrrhetinic Acid, Diacetyl Boldine, Citronellyl Methylcrotonate, Sodium Oxalate, Parfum, Carbomer, Xanthan Gum, Tocopheryl Acetate, Polysorbate 20, Bht, Ethylhexylglycerin, Sodium Hydroxide, Caprylic Capric Triglyceride, Sodium Chloride, Bha, Hydrochloric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/sesderma/azelac-ru-serum/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/sesderma/azelac-ru-serum/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/sesderma/azelac-ru-serum/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/sesderma/azelac-ru-serum/for/dark-spots
- France: https://lovi.care/skincare/fr/p/sesderma/azelac-ru-serum/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/sesderma/azelac-ru-serum/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/sesderma/azelac-ru-serum/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/sesderma/azelac-ru-serum/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/sesderma/azelac-ru-serum/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/sesderma/azelac-ru-serum/for/dark-spots (this page)
- Singapore: https://lovi.care/skincare/sg/p/sesderma/azelac-ru-serum/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/sesderma/azelac-ru-serum/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/sesderma/azelac-ru-serum/for/dark-spots