# Sesderma Azelac RU Liposomal Serum for oily skin

**Lovi Fit: High fit for oily skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/au/p/sesderma/azelac-ru-liposomal-serum/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [Sesderma](https://lovi.care/skincare/au/brands/sesderma)
Category: [Serums and treatments](https://lovi.care/skincare/au/best/serums)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily skin; a few serums fit it even better.

## Why this fit

- Highly suitable for oily skin, this serum utilizes BHA and Retinol to regulate cell turnover and exfoliate, addressing concerns like oily shine by promoting smoother skin texture.
- Azelaic acid and tranexamic acid offer moderate brightening and evening of skin tone, complementing the primary function for oily skin.
- The formulation is safe for your oily skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/sesderma/azelac-ru-liposomal-serum/for/oily-skin): High (this page)
- [Dry skin](https://lovi.care/skincare/au/p/sesderma/azelac-ru-liposomal-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/au/p/sesderma/azelac-ru-liposomal-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/au/p/sesderma/azelac-ru-liposomal-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/au/p/sesderma/azelac-ru-liposomal-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/au/p/sesderma/azelac-ru-liposomal-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/au/p/sesderma/azelac-ru-liposomal-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/au/p/sesderma/azelac-ru-liposomal-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/sesderma/azelac-ru-liposomal-serum/for/oily-acne-prone-skin): High

## Key ingredients

Azelaic Acid, Tranexamic Acid, Retinol, Niacin, 4-Butylresorcinol

## What the research says

- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Application of 15% azelaic acid gel significantly reduced post-inflammatory erythema and hyperpigmentation, decreased hemoglobin and melanin content, improved quality of life, and contributed to acne improvement in patients with mild to moderate acne compared to placebo. ([Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/))
- Azelaic acid nanocrystal hydrogel 10% achieved a higher success rate and greater lesion reduction than azelaic acid cream 20% in patients with mild to moderate facial acne. ([Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/))
- Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2023](https://pubmed.ncbi.nlm.nih.gov/36729399/))
- Topical administration of 20% azelaic acid cream and 5% tranexamic acid solution comparably improved acne-related postinflammatory hyperpigmentation in patients with acne vulgaris, while tranexamic acid demonstrated a significantly better safety profile at week 4. ([Journal of Research in Medical Sciences, 2023](https://pubmed.ncbi.nlm.nih.gov/37213446/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- The 4-n-butylresorcinol dissolving microneedle patch demonstrated safety and was more than two times more effective than the control patch in skin depigmentation among 45 subjects over 8 weeks. ([Journal of Cosmetic Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/26341915/))
- 4-n-butylresorcinol inhibits human tyrosinase and melanin production more potently than hydroquinone, arbutin, and kojic acid, and visibly reduces age spots within 8 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2013](https://pubmed.ncbi.nlm.nih.gov/23205541/))
- Combined application of dissolving microneedle patches on serum-treated skin successfully delivered more 4-n-butylresorcinol and showed higher efficacy in reducing patients' melanin index and hyperpigmented regions compared to traditional DMN-only and serum-only applications. ([Molecular Pharmaceutics, 2017](https://pubmed.ncbi.nlm.nih.gov/28447799/))

## What reviewers say

Based on limited data, users frequently report this serum effectively brightens the complexion and reduces hyperpigmentation like melasma, sun spots, and acne marks, leading to smoother and more luminous skin. Many appreciate its fast absorption and lightweight feel. Some users with sensitive or dry skin find it can be drying and recommend using a moisturizer.

- Liked: Fast absorption (mostly mentioned)
- Liked: Fades dark spots (often mentioned)
- Liked: Improves texture (often mentioned)
- Liked: Acne control (sometimes noted)
- Disliked: Drying effect (sometimes noted)
- Disliked: High price (rarely noted)
- Disliked: Slow results (rarely noted)
- Disliked: Sticky finish (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Sesderma Azelac RU Liposomal Serum a great fit for oily skin?

This serum is a great fit because it uses BHA and retinol to gently exfoliate and keep oily shine under control for smoother skin. It also includes azelaic acid and tranexamic acid to help brighten and even out your skin tone safely without irritation.
Sources: [Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/)

### Which ingredients make this serum a good fit for oily skin?

BHA and retinol make this serum a great fit for oily skin by helping to regulate cell turnover and exfoliate, which reduces oily shine and keeps skin smooth. Azelaic acid and tranexamic acid also help brighten and even out skin tone safely.
Sources: [Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/)

### What does Azelaic Acid do for oily skin?

Azelaic acid helps calm acne and clear out pores without changing how much oil your skin makes. It targets multiple causes of breakouts and helps fade dark spots left behind by pimples.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34731527/), [Acta Dermato-venereologica. Supplementum, 1989](https://pubmed.ncbi.nlm.nih.gov/2475995/)

### What does Tranexamic Acid do for oily skin?

Tranexamic acid helps oily skin by calming redness and keeping the skin barrier strong, which is especially useful when dealing with stubborn dark spots and uneven tone. This ingredient is unlikely to clog pores and may improve overall skin texture while balancing the complexion.
Sources: [International Journal of Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/23967870/), [Clinical, Cosmetic and Investigational Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38895607/)

### Where does this serum go in a skincare routine for oily skin?

This serum goes in your evening routine, applied after cleansing and before your moisturizer. Putting it at night keeps things simple and helps protect your skin around sun exposure.

### Can I use this serum with vitamin C, and in what order?

You can use this serum with vitamin C by applying vitamin C in your morning routine and this treatment at night, as this helps avoid combining too many active ingredients at once.

### How often should I use this serum?

This serum is used in your evening routine, starting at once a week and slowly increasing the frequency if your skin tolerates it well. Retinol and azelaic acid help smooth texture and brighten tone safely over time.
Sources: [Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/)

### Can this serum clog pores, cause breakouts or purging for oily skin?

This serum is unlikely to clog pores or cause breakouts on oily skin, as it uses ingredients like BHA and retinol to gently clear dead skin and keep pores clean. It has a great safety profile for this skin type, with no harsh ingredients that typically trigger irritation.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (parfum) and drying alcohol (alcohol and alcohol denat).

## Alternatives for oily skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/au/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-skin) — Superior fit — A$16.95 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/au/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/oily-skin) — Superior fit — A$52.32 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/au/p/neogen-dermalogy/real-vita-c-serum/for/oily-skin) — High fit — A$50.60 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/au/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — A$13.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/au/p/some-by-mi/snail-truecica-miracle-repair-toner/for/oily-skin) — Superior fit — A$34.66 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/au/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-skin) — Superior fit — A$22.99 at Amazon

## Where to buy

No store in Australia has a checked price for this product, so the page shows none.

## Ingredients

Water, Lecithin, Propanediol, Alcohol, Bellis Perennis Flower Extract, Polymethyl Methacrylate, Peg-40 Hydrogenated Castor Oil, Propylene Glycol, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, 4-Butylresorcinol, Alcohol Denat, Ascorbyl Glucoside, Azelaic Acid, Bha, Bht, Caprylic Capric Triglyceride, Carbomer, Citronellyl Methylcrotonate, Grapefruit Fruit Extract, Diacetyl Boldine, Dipotassium Phosphate, Disodium Edta, Disodium Phosphate, Ethylhexylglycerin, Glycerin, Glycyrrhetinic Acid, Hydrochloric Acid, Hydroxypropyl Cyclodextrin, Melissa Officinalis Leaf Extract, Morus Alba Root Extract, Niacin, Nicotiana Benthamiana Sh-Polypeptide-7, Parfum, Peg Ppg-20 6 Dimethicone, Phenethyl Alcohol, Phenoxyethanol, Polysorbate 20, Potassium Phosphate, Potassium Sorbate, Retinal, Retinol, Sodium Chloride, Sodium Cholate, Sodium Hydroxide, Tocopheryl Acetate, Tranexamic Acid, Triethanolamine, Triisopropanolamine, Undecylenoyl Phenylalanine, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/sesderma/azelac-ru-liposomal-serum/for/oily-skin
- United Kingdom: https://lovi.care/skincare/uk/p/sesderma/azelac-ru-liposomal-serum/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/sesderma/azelac-ru-liposomal-serum/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/sesderma/azelac-ru-liposomal-serum/for/oily-skin
- France: https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/sesderma/azelac-ru-liposomal-serum/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/sesderma/azelac-ru-liposomal-serum/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/sesderma/azelac-ru-liposomal-serum/for/oily-skin
- Canada: https://lovi.care/skincare/ca/p/sesderma/azelac-ru-liposomal-serum/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/sesderma/azelac-ru-liposomal-serum/for/oily-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/sesderma/azelac-ru-liposomal-serum/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/sesderma/azelac-ru-liposomal-serum/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/sesderma/azelac-ru-liposomal-serum/for/oily-skin