# REJURAN DUAL EFFECT AMPOULE for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/au/p/rejuran/dual-effect-ampoule/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [REJURAN](https://lovi.care/skincare/au/brands/rejuran)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/au/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other moisturizers fit it better.

## Why this fit

- Offers moderate benefits for your combination skin, as hyaluronic acid and niacinamide provide excellent hydration and seboregulation to balance oilier and drier areas.
- While the formula is generally supportive for hydration and soothing with ingredients like Blackberry Leaf Extract and Aloe Barbadensis Leaf Juice, it does not directly address your primary concerns of acne, blemishes, and breakouts.
- The product is safe for your combination skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing agents like Calendula Officinalis Flower Extract.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/rejuran/dual-effect-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/au/p/rejuran/dual-effect-ampoule/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/au/p/rejuran/dual-effect-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/au/p/rejuran/dual-effect-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/au/p/rejuran/dual-effect-ampoule/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/au/p/rejuran/dual-effect-ampoule/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/au/p/rejuran/dual-effect-ampoule/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/au/p/rejuran/dual-effect-ampoule/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/rejuran/dual-effect-ampoule/for/oily-acne-prone-skin): Average

## Key ingredients

Blackberry Leaf Extract, Glycyrrhiza Glabra Extract Licorice Extract, Calendula Officinalis Flower Extract

## What the research says

- A blackberry and dill extract combination synergistically increased skin elasticity and induced elastogenesis compared to each ingredient alone and placebo. ([International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/32583541/))
- Tropical highland blackberry juice reduced UVB-mediated DNA damage and increased apoptosis in human epidermal keratinocytes and a reconstituted skin equivalent model. ([Photochemistry and Photobiology, 2013](https://pubmed.ncbi.nlm.nih.gov/23711186/))
- Strawberry and blackberry crude extracts, anthocyanin-enriched fractions, and proanthocyanidin-enriched fractions demonstrated anti-inflammatory effects through ROS reduction, gene expression inhibition, and NO suppression, while anthocyanin fractions promoted fibroblast migration in vitro. ([Food Research International, 2019](https://pubmed.ncbi.nlm.nih.gov/31108769/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical application of Calendula officinalis extract cream significantly improved skin hydration and firmness (reflected in significant changes in R0 and R6 parameters) in 21 healthy human volunteers compared to a base cream. ([Acta Poloniae Pharmaceutica, 2011](https://pubmed.ncbi.nlm.nih.gov/21928714/))
- Treatment with standardized extract of Calendula officinalis L. led to a shorter epithelization time and faster healing speed compared to mineral oil in patients with acute skin loss wounds of the hand and fingers healing by secondary intention. ([Tissue Barriers, 2022](https://pubmed.ncbi.nlm.nih.gov/34674610/))
- Topical administration of Calendula provides weak evidence of effectiveness in acute and chronic wounds compared to standard treatments based on a narrative review of available trials. ([Wounds, 2008](https://pubmed.ncbi.nlm.nih.gov/25941793/))

## Why other moisturizers fit acne-prone skin better

- Gluconolactone 14% solution significantly improved mild to moderate acne by reducing inflamed and non-inflamed lesions similarly to 5% benzoyl peroxide, but with fewer side-effects in 150 patients. ([The Australasian Journal of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1303072/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))

## What reviewers say

This ampoule is widely praised for delivering the "glass skin" look, with users reporting immediate improvements in hydration, radiance, and skin texture. It is particularly favored by those with aging or damaged skin for its ability to smooth fine lines and repair the skin barrier using its signature salmon DNA (PDRN) formula, though its high price point is a common contention.

- Liked: Instant Glow (mostly mentioned)
- Disliked: High price point (mostly mentioned)
- Liked: Deep Hydration (often mentioned)
- Liked: Texture Smoothing (often mentioned)
- Disliked: Packaging issues (often mentioned)
- Liked: Fast Absorption (sometimes noted)
- Liked: Soothing & Repair (sometimes noted)
- Disliked: Breakouts/Irritation (rarely noted)
- Disliked: Heavy/Sticky finish (rarely noted)
- Disliked: Not hydrating enough (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Rejuran Dual Effect work for acne-prone skin?

REJURAN DUAL EFFECT AMPOULE works moderately well for acne-prone skin because it hydrates and calms, but it does not directly target breakouts and blemishes. A product of this type needs effective ingredients like niacinamide and hyaluronic acid to help clear acne and keep moisture balanced without causing excess oiliness.

### Which ingredients make this serum a good fit for acne-prone skin?

This moisturizing treatment works for acne-prone skin because hyaluronic acid and niacinamide help balance oil while keeping skin hydrated, and soothing ingredients like calendula flower extract and aloe vera leaf juice calm it down. However, because it does not directly target breakouts, a moisturizing treatment for this skin needs ingredients like niacinamide and peptides to clear blemishes and keep oil under control.

### What does Blackberry Leaf Extract do for acne-prone skin?

Blackberry Leaf Extract helps calm angry skin and balances oil, making it a great addition to your routine if you deal with breakouts. It works to soothe redness and may help keep pores clear for a smoother, healthier look.

### What does Licorice Extract do for acne-prone skin?

Licorice extract helps calm red, angry blemishes and fades the dark spots left behind by breakouts. It also helps balance oil and soothe irritation, making it a great addition to your routine if you deal with frequent breakouts.
Sources: [Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/), [The Journal of Dermatological Treatment, 2003](https://pubmed.ncbi.nlm.nih.gov/14522625/)

### Where does this serum go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing, though some of these can also be used in the morning or twice a day. A product of this type for acne-prone skin needs ingredients that directly target breakouts and blemishes, such as salicylic acid or benzoyl peroxide.

### Can I use this serum with retinol, and in what order?

You can use this treatment with retinol by applying it before your retinol step to help keep your skin calm and hydrated. Using a soothing, barrier-supporting moisturizer alongside retinol helps reduce dryness and irritation while improving your skin comfort.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37276158/)

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. This product of this type needs targeted ingredients that help clear blemishes and calm breakouts to truly fit acne-prone skin.

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to cause breakouts or clog pores on acne-prone skin, as it contains gentle, soothing ingredients without harsh irritants. However, because it does not directly target blemishes, acne-prone skin needs a product with ingredients that clear pores and address breakouts more actively.

### Can I use this serum around the eyes or on my body?

You can use this moisturizing treatment around the eyes and on the body because its soothing formula is safe for delicate skin. To properly care for acne-prone skin, a product of this type needs targeted blemish-fighting ingredients like salicylic acid and gentle exfoliants.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [MEDI-PEEL Peptide 9 Volume White Cica All-in-one Essence](https://lovi.care/skincare/au/p/medi-peel/peptide-9-volume-white-cica-all-in-one-essence/for/acne-prone-skin) — High fit — A$38.48 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/au/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/acne-prone-skin) — High fit — A$42.40 at Amazon
- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/au/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin) — Average fit — A$50.00 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/au/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — A$13.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/au/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — A$34.66 at Amazon
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/au/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/acne-prone-skin) — Superior fit — A$80.43 at Amazon

## Where to buy

- Amazon.com.au: A$177.00 (https://www.amazon.com.au/dp/B0GVYBD9DD?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Blackberry Leaf Extract, Glycyrrhiza Glabra Extract Licorice Extract, Calendula Officinalis Flower Extract, Aloe Barbadensis Leaf Juice, Blueberry Fruit Extract, Morus Nigra Fruit Extract, Peg-6, Glycerin, Water, Hyaluronic Acid, Niacinamide, Dipropylene Glycol, Butylene Glycol, 1,2-Hexanediol, Carbomer, Gerotine Hydrolyzed Dna, Hydrolyzed Dna, Xanthan Gum, Polysorbate 20, Adenosine, Tocopheryl Acetate, Bisabolol, Arbutin, Ethylhexylglycerin, Caprylyl Glycol, Hexylene Glycol, Trehalose, Urea, Serine, Pentylene Glycol, Glyceryl Polyacrylate, Algin, Pullulan, Disodium Phosphate, Potassium Phosphate, Squalane, Hydrogenated Lecithin, Ceramide Np, Oleic Acid, Inulin Lauryl Carbamate, Cholesterol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/rejuran/dual-effect-ampoule/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/rejuran/dual-effect-ampoule/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/rejuran/dual-effect-ampoule/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/rejuran/dual-effect-ampoule/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/rejuran/dual-effect-ampoule/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/rejuran/dual-effect-ampoule/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/rejuran/dual-effect-ampoule/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/rejuran/dual-effect-ampoule/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/rejuran/dual-effect-ampoule/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/rejuran/dual-effect-ampoule/for/acne-prone-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/rejuran/dual-effect-ampoule/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/rejuran/dual-effect-ampoule/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/rejuran/dual-effect-ampoule/for/acne-prone-skin