Perricone MD Rejuvenating Moisturizer for dry sensitive skin
Acyl-Glutathione
Tetrahexyldecyl Ascorbate
Ribose
Lactic Acid
Macadamia Ternifolia Seed Oil
Average
- AverageDry Skin Fit
- AverageEffectiveness
- Low RiskSafety
Works for dry sensitive skin; other moisturizers fit it better.
- Clinical, Cosmetic and Investigational Dermatology, 2017
- Clinical, Cosmetic and Investigational Dermatology, 2014
This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate suitability for your dry skin, as glycerin and macadamia ternifolia seed oil provide essential hydration and support barrier resilience, while S-Palmitoylglutathione offers antioxidant benefits.
- While it addresses general hydration for dry or flaky skin, the lactic acid and parfum may pose a slight irritation risk for your sensitive skin.
- The product is generally safe for your skin, with a low potential for adverse reactions.
How to apply
- Could be used as part of your AM or PM routine. Start using this moisturizer 3 times a week and move to daily use if your dry skin tolerates it well.
- Apply this moisturizer after cleansing and toner in the morning, or after your serum in the evening. Always pair it with SPF in the morning.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it harshly to protect your sensitive skin.
- Apply the moisturizer on slightly damp skin to help with hydration absorption. This also works well for dry and flaky skin types.
- Do a patch test before your first use. Avoid the eye area to prevent any irritation.
People Say
★4.6Overall rating based on 1.0k+ reviewsThis moisturizer is praised for its rich texture that plumps, firms, and smooths aging or dry skin without greasiness. Many users report reduced fine lines and improved radiance. Some users experienced product pilling or sensitivity to the fragrance.
Highlights
Deeply hydrating Often Mentioned
- “Keeps my skin moist without the acne.”
- “Very rich and nourishing.”
- “Replenishes fragile skin.”
Improves texture Often Mentioned
- “Skin looks smoother, with no discoloration.”
- “Visibly plumper, firmer, and smoother.”
- “Skin feels better, smoother and brighter.”
Non-greasy formula Sometimes Noted
- “It's non greasy, absorbs right in.”
- “Absorbs quickly without any residual grease.”
- “Not greasy or sticky.”
Reduces lines Sometimes Noted
- “Plumps my skin to reduce the look of fine lines.”
- “Targets deep wrinkles and creases.”
- “Saw a reduction in the appearance of fine lines.”
Product pilling Sometimes Noted
- “When I try to apply my liquid makeup over it it rolls up.”
- “It all pealed away. It looked like a snow storm.”
- “I do not really experience pilling unless I use too much.”
Fragrance sensitivity Rarely Noted
- “A few reviewers found the fragrance too strong.”
- “Unfortunately had an allergic reaction.”
- “Experienced minor irritation.”
White cast Rarely Noted
- “Leaves this white flaky texture on my face.”
- “Had to really blend so it didn't appear to leave a white cast.”
- “Doesn't leave a whitecast (after 7 days).”
Sources: lovi.care, perriconemd.com, lovelyskin.com, walmart.com, ipsy.com, nordstrom.com, and more
Questions and answers
How well does Perricone MD Rejuvenating Moisturizer work for dry sensitive skin?
This moisturizer works moderately well for dry skin, as its ingredients provide essential hydration and support skin barrier resilience, though the lactic acid and added fragrance may pose a slight irritation risk for sensitive skin. A product of this type needs soothing, highly effective ingredients that provide deep hydration and nourishment without any risk of irritation, along with moisturizing agents and barrier-supporting ingredients that contain no allergens.
Clinical, Cosmetic and Investigational Dermatology, 2014Journal of the European Academy of Dermatology and Venereology, 2024
Which ingredients make this cream a good fit for dry sensitive skin?
Glycerin and macadamia oil help this cream fit your dry skin by providing essential moisture and supporting your skin barrier. To work well for sensitive skin of this type, a moisturizer needs soothing, deeply nourishing ingredients that deliver strong hydration without any risk of irritation or added allergens.
What does Acyl-Glutathione do for dry sensitive skin?
Acyl-Glutathione helps protect dry sensitive skin against environmental and oxidative stress while improving overall moisture and smoothness. It is unlikely to cause irritation and supports a calm, healthy look.
Journal of the European Academy of Dermatology and Venereology, 2024Clinical, Cosmetic and Investigational Dermatology, 2014
What does Vitamin C do for dry sensitive skin?
Vitamin C helps make dry, sensitive skin feel softer and calmer while improving firmness and reducing redness. Studies show that gentle forms of vitamin C can improve skin hydration and elasticity safely without causing irritation.
Where does it go in a skincare routine for dry sensitive skin?
For your dry sensitive skin, apply this moisturizing treatment in the evening as a treatment step before your moisturizer. A product of this type needs soothing ingredients, gentle hydrators, and fragrance-free formulas to comfort dry skin without causing irritation.
Can I use this cream with retinol, and in what order?
You can use this treatment alongside retinol by applying your retinol first, letting it absorb, and then following with this cream at night. Because your skin is sensitive, starting this combination slowly helps you check for any irritation from the lactic acid and added fragrance. Dry and sensitive skin types need a deeply nourishing treatment packed with soothing ingredients and extra barrier support to comfortably handle active ingredients like retinol.
How often should I use it?
This moisturizer works for your dry sensitive skin, but the lactic acid and added fragrance may cause a slight irritation risk, so you may want to start using it just once a week. If your skin feels comfortable and tolerates it well, you can gradually increase how often you apply it. A product for this skin type needs gentle, hydrating ingredients like glycerin and plant oils to soothe dryness without harsh acids or perfumes that can upset sensitive areas.
Can this cream clog pores, cause breakouts or purging for dry sensitive skin?
This cream is unlikely to clog pores or cause breakouts for dry sensitive skin, though it may occasionally cause slight irritation. To truly thrive, dry sensitive skin needs soothing, fragrance-free hydration and barrier-strengthening ingredients without harsh acids or added perfumes.
Can I use it around the eyes or on my body?
This moisturizer is generally safe for the skin, though you should be cautious around the eyes since that area is much thinner and more delicate than the rest of the body. While it helps keep skin soft and smooth, a product for dry sensitive skin needs rich nourishing oils and gentle calming ingredients without any added fragrance to avoid irritation.
Is this cream fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (parfum, citronellol, limonene, and linalool). Cetearyl alcohol is a fatty alcohol, which soften the skin.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2014Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls.
Journal of the European Academy of Dermatology and Venereology, 2024Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity.
The Journal of Clinical and Aesthetic Dermatology, 2025RayGel reduced skin reaction severity with a lower average score of 93.7 compared to 123.3 for the placebo group in patients undergoing whole breast external-beam irradiation.
American Journal of Surgery, 2005Combining high-intensity focused ultrasound with a topical agent containing glutathione and hyaluronic acid significantly improves skin quality, fine wrinkles, hyperpigmentation, hydration, and brightness in female volunteers compared to the topical agent alone.
The Journal of Dermatological Treatment, 2024Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin.
Cutis, 2004Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties.
Journal of the American Academy of Dermatology, 1992A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins.
The Journal of Clinical and Aesthetic Dermatology, 2020
Ingredients
Water, Ethylhexyl Palmitate, Glycerin, Dimethicone, Cetearyl Alcohol, Glyceryl Stearate, Polysorbate 60, Palmitoyl Glycine, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Peg-100 Stearate, Ribose, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Salvia Hispanica Seed Oil, Tocopherol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Polyacrylamide, Sodium Acrylates Copolymer, Polysilicone-11, Hydrogenated Polyisobutene, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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