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Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer for sensitive skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer

Average

  • HighNormal Skin Fit
  • AverageEffectiveness
  • HighSafety

Works for sensitive skin; other moisturizers fit it better.

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Offers moderate moisturizing benefits for your normal skin, as Glycerin and Palmitoyl Glycine hydrate and smooth texture, but these ingredients do not directly address your primary concerns of redness and irritation.
  • While S-Palmitathione and Tetrahexyldecyl Ascorbate provide antioxidant support beneficial for normal skin, they offer limited impact on inflammation.
  • The product is safe for your sensitive skin, containing no harsh or prohibited ingredients that would cause irritation.

How to apply

  • Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
  • Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
  • Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
  • You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
  • Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .

People Say

★4.5Overall rating based on 500+ reviews

This moisturizer is highly praised for its rich, velvety texture that absorbs quickly to provide intense hydration, making it a favorite for dry and mature skin types. Users frequently report a visible improvement in skin softness, radiance, and a firmer, more supple appearance, though some note that it may not fully erase deep-set wrinkles.

Highlights

  • Deeply hydrating Mostly Mentioned
    • “Keeps skin hydrated all day.”
    • “Great for dry patches.”
    • “Feels very moisturizing.”
  • Fast absorbing Often Mentioned
    • “Absorbs fast, not greasy.”
    • “No residue feel afterwards.”
    • “Absorbs quickly without stickiness.”
  • Pleasant texture Often Mentioned
    • “Light, velvety texture.”
    • “Not too heavy, not too light.”
    • “Creamy, not greasy.”
  • Expensive price Often Mentioned
    • “On the steep side.”
    • “More expensive side.”
    • “Price is quite high.”
  • Improves radiance Sometimes Noted
    • “Produces a radiant glow.”
    • “Skin looks healthier.”
    • “Imparts a beautiful radiance.”
  • Limited wrinkle results Sometimes Noted
    • “Haven't noticed much difference.”
    • “Not as good as advertised.”
    • “Deep lines remain.”
  • Strong fragrance Rarely Noted
    • “Fragrance too strong.”
    • “Concerned about fragrance.”
    • “Experienced minor irritation.”

Sources: lovi.care, perriconemd.com, mecca.com.au, macys.com, nordstrom.com, ipsy.com, and more

Questions and answers

How well does Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer work for sensitive skin?

This moisturizer works reasonably well for sensitive skin, hydrating and smoothing texture safely without causing irritation, though it does little to directly calm redness. Sensitive skin typically needs soothing ingredients like fermented Centella Asiatica, cica ceramide, and nourishing oils to strengthen the skin barrier and target redness.

Clinical, Cosmetic and Investigational Dermatology, 2017

Which ingredients make this cream a good fit for sensitive skin?

Glycerin helps hydrate and smooth your skin safely, but a moisturizing treatment for sensitive skin needs soothing ingredients like fermented Centella Asiatica, cica ceramide, and nourishing oils to calm redness and irritation.

Clinical, Cosmetic and Investigational Dermatology, 2017

What does Acyl-Glutathione do for sensitive skin?

Acyl-glutathione helps protect sensitive skin by reducing oxidative stress and fighting environmental damage, though a product for this skin type also needs soothing ingredients to calm irritation and strengthen the skin barrier.

Journal of the European Academy of Dermatology and Venereology, 2024Journal of Cosmetic Dermatology, 2026

What does Vitamin C do for sensitive skin?

For sensitive skin, Vitamin C helps calm redness and evens out dark spots while improving overall skin quality and radiance. Daily use is generally well-tolerated and may help protect against environmental stress.

Journal of Cosmetic Dermatology, 2019Journal of Cosmetic Dermatology, 2024

Where does this cream go in a skincare routine for sensitive skin?

This moisturizing treatment goes in the evening routine after a cleanser and soothing toner, followed by a moisturizer. Sensitive skin needing a better fit requires products with soothing botanical extracts and gentle anti-inflammatory ingredients to calm redness and irritation.

Can I use this cream with retinol, and in what order?

You can use this treatment after your retinol at night, provided your sensitive skin tolerates the lactic acid and other active ingredients well. Because this product does not directly target redness, sensitive skin needs a moisturizer or treatment packed with soothing plant extracts and barrier-strengthening ceramides to keep skin calm and smooth.

How often should I use this cream?

This cream works well for daily use to hydrate and smooth your skin, though it offers an average fit since it does not directly target redness. To properly care for sensitive skin, a product of this type needs soothing and anti-inflammatory ingredients that calm irritation.

Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021

Can this cream clog pores, cause breakouts or purging for sensitive skin?

This cream is unlikely to clog pores or cause breakouts for sensitive skin because it is free of harsh ingredients that typically cause irritation. However, because it provides only moderate moisture without directly calming redness, sensitive skin prone to breakouts often benefits more from gentle, fragrance-free hydrators paired with soothing plant extracts like centella asiatica.

Clinical, Cosmetic and Investigational Dermatology, 2017

Can I use this cream around the eyes or on my body?

This cream is generally safe to use on delicate areas like the face, but because it is an average fit for sensitive skin, it needs soothing plant oils and gentle hydrators to properly comfort and protect thin skin without causing irritation.

Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (citronellol, limonene, and linalool). Cetearyl alcohol is a fatty alcohol, which soften the skin.

What the research says

Why other moisturizers fit sensitive skin better

  • A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.

    Journal of Cosmetic Dermatology, 2024

  • Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

    American Journal of Clinical Dermatology, 2002

  • A dexpanthenol-containing cream accelerated skin barrier repair, increased stratum corneum hydration, reduced skin roughness, and decreased skin redness compared to vehicle and untreated controls in sodium lauryl sulphate-irritated skin.

    The Journal of Dermatological Treatment, 2002

Ingredients

Water, Ethylhexyl Palmitate, Glycerin, Dimethicone, Cetearyl Alcohol, Glyceryl Stearate, Polysorbate 60, Palmitoyl Glycine, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Peg-100 Stearate, Ribose, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Salvia Hispanica Seed Oil, Tocopherol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Polyacrylamide, Sodium Acrylates Copolymer, Polysilicone-11, Hydrogenated Polyisobutene, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Citronellol, Hydroxycitronellal, Limonene, Linalool

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

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How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play