Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer for dry skin
Acyl-Glutathione
Tetrahexyldecyl Ascorbate
Lactic Acid
Macadamia Ternifolia Seed Oil
Vitamin F Blend
High
- SuperiorDry Skin Fit
- HighEffectiveness
- HighSafety
A great choice for dry skin; a few moisturizers fit it even better.
- International Journal of Cosmetic Science, 2010
- Journal of the European Academy of Dermatology and Venereology, 2024
This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Excellent suitability for your dry skin is provided by glycerin, linum usitatissimum seed oil, and macadamia ternifolia seed oil, which offer humectant and emollient actions to combat dryness and flakiness.
- Palmitoyl glycine and S-palmitoylglutathione further enhance moisturizing and antioxidant benefits, supporting skin elasticity and providing relevant benefits for your dry or flaky skin.
- The product is safe for your dry skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.
How to apply
- Could be used as part of your AM or PM routine. Start using it 3 times a week and work your way up to daily use.
- Apply your moisturizer after your toner and before your sunscreen in the morning. At night, use it as the final step after your serum.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing to keep your dry skin happy.
- Apply the moisturizer on slightly damp skin to help lock in extra hydration. This is great for soothing dry and flaky areas .
- Avoid the sensitive eye area and do a patch test before your first use .
People Say
★4.5Overall rating based on 500+ reviewsThis moisturizer is highly praised for its rich, velvety texture that absorbs quickly to provide intense hydration, making it a favorite for dry and mature skin types. Users frequently report a visible improvement in skin softness, radiance, and a firmer, more supple appearance, though some note that it may not fully erase deep-set wrinkles.
Highlights
Deeply hydrating Mostly Mentioned
- “Keeps skin hydrated all day.”
- “Great for dry patches.”
- “Feels very moisturizing.”
Fast absorbing Often Mentioned
- “Absorbs fast, not greasy.”
- “No residue feel afterwards.”
- “Absorbs quickly without stickiness.”
Pleasant texture Often Mentioned
- “Light, velvety texture.”
- “Not too heavy, not too light.”
- “Creamy, not greasy.”
Expensive price Often Mentioned
- “On the steep side.”
- “More expensive side.”
- “Price is quite high.”
Improves radiance Sometimes Noted
- “Produces a radiant glow.”
- “Skin looks healthier.”
- “Imparts a beautiful radiance.”
Limited wrinkle results Sometimes Noted
- “Haven't noticed much difference.”
- “Not as good as advertised.”
- “Deep lines remain.”
Strong fragrance Rarely Noted
- “Fragrance too strong.”
- “Concerned about fragrance.”
- “Experienced minor irritation.”
Sources: lovi.care, perriconemd.com, mecca.com.au, macys.com, nordstrom.com, ipsy.com, and more
Questions and answers
What makes Perricone MD Rejuvenating Moisturizer a great fit for dry skin?
This moisturizer is a great fit because glycerin, flaxseed oil, and macadamia seed oil work to combat dryness and flakiness. It is safe for your skin with no harsh ingredients, and ingredients like acyl-glutathione help support elasticity.
Which ingredients make this cream a good fit for dry skin?
Glycerin, linseed oil, and macadamia oil make this cream a great fit for dry skin by drawing in moisture and softening flaky areas. Ingredients like Acyl-Glutathione and vitamin F blend add extra nourishment and antioxidants to help support skin elasticity.
What does Acyl-Glutathione do for dry skin?
Acyl-glutathione helps protect dry skin by boosting antioxidant defenses and supporting moisture levels. It is unlikely to irritate dry skin and may help keep it feeling soft and smooth.
What does Vitamin C do for dry skin?
Vitamin C helps keep dry skin hydrated and makes it feel soft and smooth. Daily use may also improve overall skin texture and brightness over time.
Photochemistry and Photobiology, 2021Skin Research and Technology, 2008
Where does this cream go in a skincare routine for dry skin?
This cream is applied in the morning after a hydrating toner and before your sunscreen, and in the evening as the final step of your routine. Using a daily moisturizer helps improve visual dryness and overall skin comfort for dry skin.
Can I use this cream with retinol, and in what order?
You can use this moisturizing treatment with retinol by applying the treatment after your retinol has fully absorbed, or by using retinol in the evening and this cream during the day. This routine helps keep dry skin smooth and comfortable while keeping the risk of irritation very low.
How often should I use this cream?
This moisturizing treatment is well suited for daily use to combat dryness and keep your dry skin soft and smooth. Applying it regularly helps improve skin moisture and barrier function while remaining safe and gentle.
Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021
Can this cream clog pores, cause breakouts or purging for dry skin?
This cream is unlikely to clog pores or cause breakouts on dry skin, as it has a safe profile with no harsh ingredients that typically trigger irritation. Glycerin and nourishing seed oils help keep your skin smooth and calm without heavy buildup.
Can I use this cream around the eyes or on my body?
This moisturizing treatment is well-suited for the body, but because the skin around the eyes is much thinner than on other body regions, you should use care if applying it there to avoid potential sensitivity. Its rich formula helps combat dryness and flakiness on dry skin without irritation.
Is this cream fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (citronellol, limonene, and linalool). Cetearyl alcohol is a fatty alcohol, which soften the skin.
What the research says
Palmitoyl glycine and cocoyl alanine demonstrated complementary anti-aging properties and superior anti-wrinkle efficacy compared to a market reference ingredient in Caucasian women.
International Journal of Cosmetic Science, 2010Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls.
Journal of the European Academy of Dermatology and Venereology, 2024Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2014Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity.
The Journal of Clinical and Aesthetic Dermatology, 2025Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin.
Cutis, 2004Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties.
Journal of the American Academy of Dermatology, 1992A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins.
The Journal of Clinical and Aesthetic Dermatology, 2020Topical application of linoleic acid achieved an almost 25% reduction in the overall size of follicular casts and microcomedones over a 1-month treatment period in patients with mild acne compared to no change at placebo-treated sites.
Clinical and Experimental Dermatology, 1998Topical conjugated linolenic acid significantly reduced edema on post-procedure Day 3 and itching on Days 1 and 3, and improved wrinkling at Day 14 compared to 1% dimethicone ointment in 34 subjects undergoing fractionated CO2 laser resurfacing of the face.
The Journal of Clinical and Aesthetic Dermatology, 2017Liposomal formulation of linoleic acid significantly enhances its skin whitening effect compared to non-liposomal forms in UV-stimulated guinea pig and human skin.
Biological & Pharmaceutical Bulletin, 2004
Ingredients
Water, Ethylhexyl Palmitate, Glycerin, Dimethicone, Cetearyl Alcohol, Glyceryl Stearate, Polysorbate 60, Palmitoyl Glycine, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Peg-100 Stearate, Ribose, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Salvia Hispanica Seed Oil, Tocopherol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Polyacrylamide, Sodium Acrylates Copolymer, Polysilicone-11, Hydrogenated Polyisobutene, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Citronellol, Hydroxycitronellal, Limonene, Linalool
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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