# Perricone MD Deep Crease Serum for oily skin

**Lovi Fit: Average fit for oily skin.**
Oily Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/au/p/perricone-md/deep-crease-serum/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [Perricone MD](https://lovi.care/skincare/au/brands/perricone-md)
Category: [Serums and treatments](https://lovi.care/skincare/au/best/serums)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for oily skin as Squalane and Macadamia Ternifolia Seed Oil provide emollient action, but it lacks sufficient ingredients for optimal oil control to address your oily shine.
- The presence of Palmitoyl Tripeptide-5 and Acetyl Hexapeptide-8 offers excellent wrinkle reduction for treating fine lines and wrinkles, which is a supportive benefit for your skin.
- The safety profile is good, with no risks of irritation for your oily skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/perricone-md/deep-crease-serum/for/oily-skin): Average (this page)
- [Dry skin](https://lovi.care/skincare/au/p/perricone-md/deep-crease-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/au/p/perricone-md/deep-crease-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/au/p/perricone-md/deep-crease-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/au/p/perricone-md/deep-crease-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/au/p/perricone-md/deep-crease-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/au/p/perricone-md/deep-crease-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/au/p/perricone-md/deep-crease-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/perricone-md/deep-crease-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Acyl-Glutathione, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects. ([Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))

## Why other serums fit oily skin better

- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Users in their 40s and 50s frequently praise this serum for its lightweight, non-greasy feel and its ability to hydrate and soften the appearance of expression lines. While results are gradual, consistent use leads to firmer, smoother-looking skin.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Hydrating formula (often mentioned)
- Liked: Softens deep lines (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Improves firmness (sometimes noted)
- Disliked: Dropper issues (sometimes noted)
- Disliked: Gradual results (sometimes noted)
- Disliked: Fragrance sensitivity (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week and build up to daily use if your skin tolerates it well.
- Apply the serum after cleansing and toning, but right before your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin. Let it absorb ⏱ for a minute before applying the next product.
- Apply the serum on clean and dry skin since your skin is not sensitive and you want to target oily shine. This helps control excess oil throughout the night.
- Avoid the delicate eye area and do a patch test before using the serum for the very first time.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Perricone MD Deep Crease Serum work for oily skin?

Perricone MD Deep Crease Serum offers moderate suitability for your oily skin because while it helps smooth out fine lines and wrinkles, it lacks enough ingredients to control oily shine. To work best for oily skin, a treatment of this type needs effective ingredients like niacinamide to manage excess oil and reduce enlarged pores while keeping the skin comfortable.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/)

### Which ingredients make this serum a good fit for oily skin?

Palmitoyl Tripeptide-5 and Acetyl Hexapeptide-8 make this serum a good fit for oily skin by helping reduce fine lines and wrinkles. Because this product offers only a moderate fit for oily skin, a product of this type needs ingredients like niacinamide, ferulic acid, and zinc PCA to control excess oil and manage shine.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/)

### What does Acyl-Glutathione do for oily skin?

Acyl-Glutathione is unlikely to be the best fit for oily skin, as this skin type needs balancing ingredients and lightweight hydrators to control shine and keep pores clear without feeling heavy.

### What does Palmitoyl Glutathione do for oily skin?

Palmitoyl glutathione helps keep oily skin looking smooth and clear while improving its overall moisture. This ingredient is unlikely to cause irritation and may support a balanced, healthy complexion.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### Where does this serum go in a skincare routine for oily skin?

This treatment goes in the evening routine after cleansing and before moisturizing, for simplicity and extra safety around sun exposure. It works for oily skin, though this skin type needs oil-control ingredients to better manage oily shine.

### Can I use this serum with retinol, and in what order?

You can use this treatment with retinol by applying your retinol first and following it with this serum, or by using retinol at night and this serum in the morning. This routine helps you smooth fine lines while minimizing the likelihood of skin discomfort. To best suit oily skin, this type of product also needs ingredients that control oil and reduce shine.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/)

### How often should I use this serum?

You can use this treatment in the evening as part of your nightly routine. This product offers moderate suitability for oily skin, but to properly manage oily shine, this skin type needs oil-controlling ingredients.

### Can this serum clog pores, cause breakouts or purging for oily skin?

This serum is unlikely to cause breakouts or purging for oily skin due to a good safety profile with no harsh ingredients. However, because it contains macadamia seed oil, an oily skin type needs a product with strong oil-controlling and balancing ingredients to properly manage shine.

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum, citronellol, limonene, and linalool).

## Alternatives for oily skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/au/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-skin) — Superior fit — A$16.95 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/au/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/oily-skin) — Superior fit — A$52.32 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/au/p/neogen-dermalogy/real-vita-c-serum/for/oily-skin) — High fit — A$50.60 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/au/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — A$13.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/au/p/some-by-mi/snail-truecica-miracle-repair-toner/for/oily-skin) — Superior fit — A$34.66 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/au/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-skin) — Superior fit — A$22.99 at Amazon

## Where to buy

No store in Australia has a checked price for this product, so the page shows none.

## Ingredients

Water, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Dimethyl Mea, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Anhydroxylitol, Lactic Acid, Xylitol, Xanthan Gum, Linum Usitatissimum Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Magnesium Aspartate, Zinc Gluconate, Alaria Esculenta Extract, Glucose, Sodium Hyaluronate, Copper Gluconate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Magnesium Chloride, Caprylic Capric Triglyceride, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Caprylyl Capryl Glucoside, Caprylyl Glycol, Potassium Sorbate, Phenoxyethanol, Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/deep-crease-serum/for/oily-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/deep-crease-serum/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/deep-crease-serum/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/deep-crease-serum/for/oily-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/deep-crease-serum/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/deep-crease-serum/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/deep-crease-serum/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/deep-crease-serum/for/oily-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/deep-crease-serum/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/deep-crease-serum/for/oily-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/deep-crease-serum/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/deep-crease-serum/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/deep-crease-serum/for/oily-skin