# Paula's Choice Pro-Collagen Multi-Peptide Booster for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/au/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [Paula's Choice](https://lovi.care/skincare/au/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/au/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Offers high suitability for your combination skin, as multiple peptides like Palmitoyl Tripeptide-5 and Sh-Polypeptide-121 support skin repair and collagen production, which is beneficial for your acne and blemishes.
- Glycerin and Sodium Hyaluronate provide essential humectant action, ensuring adequate hydration for your combination skin type.
- The product is safe for your skin, with no identified risks of irritation due to the absence of harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/au/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/au/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/au/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/au/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/au/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/au/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/au/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/oily-acne-prone-skin): Average

## Key ingredients

6x Peptide Complex, Sodium Hyaluronate, Hydrolyzed Yeast Extract, Pyrus Malus Fruit Extract, Palmitoyl Tripeptide-5

## What the research says

- Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects. ([Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A cosmetic cream with 6% standardized wild apple fruit extract and a conventional emulsifier demonstrated stable antioxidant activity of 19.25 %RSC, increased skin moisturization, and a decreased melanin index by -31.40 without causing skin irritation. ([International Journal of Cosmetic Science, 2019](https://pubmed.ncbi.nlm.nih.gov/31050807/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical moisturizers improved skin barrier function and surface moisture, while a postbiotic moisturizer with yeast extract uniquely supported microbiome balance and modulated biomarkers of skin barrier, structure, and inflammation in participants and ex vivo explants exposed to environmental aggressors. ([Journal of Clinical Medicine, 2023](https://pubmed.ncbi.nlm.nih.gov/37763018/))
- A maintenance therapy with a cosmeceutical formulation containing hydroxyphenoxy propionic acid, ellagic acid, yeast extract, and salicylic acid over 20 weeks significantly improved even skin tone, spot intensity, spot size, and overall hyperpigmentation in 33 healthy subjects with moderate facial dyspigmentation. ([Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25844613/))
- A methanol yeast extract increases proliferation and migration while decreasing entrance into senescence and apoptosis phases in 3T3 fibroblast cells. ([Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/25898765/))
- Topical formulations containing 1.25% Malus sp. extract or 0.75% rutin protected against UVB-induced sunburn cells, caspase-3 activation, cyclobutane pyrimidine dimers, lipid peroxidation, and metalloproteinase formation in ex vivo skin explants and 3D tissue-engineered skin. ([Rejuvenation Research, 2020](https://pubmed.ncbi.nlm.nih.gov/32242497/))

## What reviewers say

Users report this lightweight gel booster provides immediate plumping and hydration, often improving skin texture and softening fine lines overnight. While it is highly effective for firming and layering, a moderate number of users found the scent and price to be drawbacks, and a low number experienced breakouts or redness.

- Liked: Plumps and firms (mostly mentioned)
- Liked: Hydrates and glows (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Disliked: Expensive for size (often mentioned)
- Liked: Smooths lines (sometimes noted)
- Disliked: Messy packaging (sometimes noted)
- Disliked: Unpleasant scent (sometimes noted)
- Disliked: Caused breakouts (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes the Pro-Collagen Multi-Peptide Booster a great fit for acne-prone skin?

This booster is a great fit for acne-prone skin because its multiple peptides help support skin repair and collagen production, which is beneficial for breakouts and blemishes. It also includes ingredients like glycerin and sodium hyaluronate that provide essential hydration without the risk of harsh irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/)

### Which ingredients make this treatment a good fit for acne-prone skin?

This treatment is a great fit for acne-prone skin because multiple peptides like Palmitoyl Tripeptide-5 and Sh-Polypeptide-121 support skin repair and collagen production, which helps with acne and blemishes. Additionally, glycerin and sodium hyaluronate keep this skin type properly hydrated without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/)

### What does Peptide Complex do for acne-prone skin?

Peptide Complex helps calm breakouts and keeps acne-prone skin smooth by supporting the skin barrier and reducing excess oil. This type of ingredient works best when it also includes soothing agents and barrier-strengthening ceramides.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32697858/), [Journal of Nanobiotechnology, 2023](https://pubmed.ncbi.nlm.nih.gov/36803994/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Where does this treatment go in a skincare routine for acne-prone skin?

This treatment goes in your evening routine, after cleansing and before moisturizing. Putting treatments in the evening provides simplicity and extra safety around sun exposure, though some may also be used in the morning or twice a day.

### Can I use it with retinol, and in what order?

You can use this treatment alongside retinol by applying the retinol first, letting it absorb, and then following with this peptide booster. This layering approach helps keep acne-prone skin hydrated while being unlikely to cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this treatment?

This treatment fits your acne-prone skin well and is used in the evening as part of your routine. Its peptides help support skin repair and collagen production, and it has a safe profile with no harsh ingredients.

### Can it clog pores, cause breakouts or purging for acne-prone skin?

This treatment is a great fit for your acne-prone skin and is very unlikely to cause breakouts or clog pores, as it has a very low risk of irritation and no harsh ingredients. It helps keep your skin balanced and calm while supporting skin repair.
Sources: [International Journal of Cosmetic Science, 2019](https://pubmed.ncbi.nlm.nih.gov/31050807/), [Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/)

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/au/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — A$16.95 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/au/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — A$52.32 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/au/p/neogen-dermalogy/real-vitamin-c-serum/for/acne-prone-skin) — Superior fit — A$50.60 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/au/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — A$13.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/au/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — A$34.66 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/au/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — A$24.00 at Amazon

## Where to buy

- Amazon.com.au: A$89.00 (https://www.amazon.com.au/dp/B0BV3F1X4H?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Glycerin, Pentylene Glycol, Hydrolyzed Yeast Extract, Pyrus Malus Fruit Extract, Dimethicone, Propanediol, 1,2-Hexanediol, Glyceryl Glucoside, Palmitoyl Tripeptide-72 Amide, Sh-Polypeptide-121, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Palmitoyl Tripeptide-5, Tridecapeptide-1, Polyglucuronic Acid, Sodium Hyaluronate, C9-12 Alkane, Ammonium Polyacryloyldimethyl Taurate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Polygonum Bistorta Root Extract, Bacillus Ferment, Lecithin, Sodium Phytate, Coco-Caprylate Caprate, Hexylene Glycol, Cetyl Hydroxyethylcellulose, Xanthan Gum, Ethylhexylglycerin, Caprylyl Glycol, Magnesium Chloride, Potassium Sorbate, Sodium Benzoate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/acne-prone-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/paula-s-choice/pro-collagen-multi-peptide-booster/for/acne-prone-skin