# Paula's Choice Peptide Booster for mature skin

**Lovi Fit: Superior fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/au/p/paula-s-choice/peptide-booster/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [Paula's Choice](https://lovi.care/skincare/au/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/au/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for mature skin.

## Why this fit

- Excellent compatibility with your normal skin, as multiple peptides like Palmitoyl Tripeptide-1 and Hexanoyl Dipeptide-3 Norleucine Acetate effectively stimulate collagen production to address wrinkles and fine lines.
- The inclusion of Dipotassium Glycyrrhizate and Adenosine further supports skin elasticity and provides soothing benefits, enhancing the overall plumping effect for your skin.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the presence of beneficial soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/paula-s-choice/peptide-booster/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/au/p/paula-s-choice/peptide-booster/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/au/p/paula-s-choice/peptide-booster/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/au/p/paula-s-choice/peptide-booster/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/au/p/paula-s-choice/peptide-booster/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/au/p/paula-s-choice/peptide-booster/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/au/p/paula-s-choice/peptide-booster/for/mature-skin): Superior (this page)
- [Dry sensitive skin](https://lovi.care/skincare/au/p/paula-s-choice/peptide-booster/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/paula-s-choice/peptide-booster/for/oily-acne-prone-skin): High

## Key ingredients

Peptides, Complex Amino Acid, Glycerin, Panax Ginseng Root Extract, Psidium Guajava Fruit Extract

## What the research says

- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))
- Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- An amino acid complex formulated in a Skin Recovery System reduced skin irritation and redness while accelerating the skin repair process in 37 subjects. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34694692/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Enzyme-modified ginseng extract cream significantly reduced the global photo-damage score and various roughness measures including total roughness, smoothness depth, and arithmetic roughness average compared to placebo in 23 human subjects. ([Rejuvenation Research, 2015](https://pubmed.ncbi.nlm.nih.gov/25867599/))
- A red ginseng hydrogel formulation with 1,2-hexanediol promoted selective growth of Staphylococcus epidermidis and decreased Cutibacterium acnes in 20 female subjects. ([Journal of Ginseng Research, 2022](https://pubmed.ncbi.nlm.nih.gov/35509819/))
- A 1% fermented black ginseng cream significantly reduced eye wrinkles and brightened skin color in twenty-three human subjects compared to control cream and baseline. ([Journal of Toxicology and Environmental Health. Part A, 2020](https://pubmed.ncbi.nlm.nih.gov/32564709/))
- A toner with 6% guava extract significantly reduced skin oiliness on the forehead and nose compared to the base toner in 21 volunteers over 28 days. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30964238/))
- Pre-incubation with guava crude extract significantly decreased apoptotic and dead cells and markers of oxidative damage while improving antioxidant enzyme activity in human dermal fibroblasts subjected to AAPH-mediated oxidative stress, compared to cells subjected to stress without prior pre-incubation. ([Plant Foods for Human Nutrition, 2018](https://pubmed.ncbi.nlm.nih.gov/29455277/))

## What reviewers say

Based on a very large amount of data, users with dry, dull, and aging skin report that this booster effectively plumps, hydrates, and improves overall skin elasticity. Consistent use leads to visibly firmer skin and a reduction in fine lines and wrinkles. Some users feel the results take time to manifest.

- Liked: Plumps and hydrates (mostly mentioned)
- Liked: Firms and smooths (often mentioned)
- Liked: Layers seamlessly (often mentioned)
- Liked: Lightweight, fast-absorbing (often mentioned)
- Disliked: High price point (sometimes noted)
- Disliked: Poor dropper packaging (sometimes noted)
- Disliked: Slow, subtle results (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Paula's Choice Peptide Booster one of the best fits for mature skin?

This product is an exceptional fit for mature skin because multiple peptides effectively stimulate collagen production to smooth fine lines and wrinkles. Soothing ingredients like adenosine and dipotassium glycyrrhizate further support skin elasticity and firmness while enhancing the overall plumping effect.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/)

### Which ingredients make this booster a good fit for mature skin?

This booster is an excellent fit for mature skin because it contains multiple peptides like palmitoyl tripeptide-1 to stimulate collagen production and smooth out fine lines and wrinkles. Ingredients like adenosine and dipotassium glycyrrhizate further support skin elasticity and provide soothing benefits to enhance the overall plumping effect.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/)

### What do Peptides do for mature skin?

Peptides help mature skin by signaling skin cells to boost collagen production, which improves firmness and smooths out fine lines. They are generally safe to use daily, though their ability to deliver results depends heavily on how well the formula can sink into the skin.
Sources: [International Journal of Cosmetic Science, 2009](https://pubmed.ncbi.nlm.nih.gov/19570099/), [Biomolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/39858482/)

### What do Amino Acids do for mature skin?

Amino acids help mature skin by supporting skin repair, reducing redness, and improving moisture retention for a smoother, healthier look. They may also help soothe irritation and strengthen the skin barrier over time.
Sources: [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34694692/), [Journal of Drugs in Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38834224/)

### Where does this booster go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and before moisturizing, though some can also be used in the morning or twice a day. It is very unlikely to irritate your skin due to the absence of harsh ingredients and the presence of soothing components.

### Can I use this booster with retinol, and in what order?

You can use this booster with retinol by applying the booster first and following it with your retinol product. This helps nourish and soothe the skin while minimizing any potential irritation from the retinol.

### How often should I use this booster?

You can use this treatment in the evening as part of your routine. It is a great fit for mature skin because multiple peptides and adenosine help smooth out wrinkles and improve firmness with a very low risk of irritation.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/)

### Can this booster clog pores, cause breakouts or purging for mature skin?

This booster is unlikely to clog pores, cause breakouts, or lead to purging, as it has a very safe profile with gentle, soothing ingredients and no harsh components.

### Is this booster fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/au/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — A$50.60 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/au/p/la-mer/the-regenerating-serum/for/mature-skin) — High fit — A$740.13 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/au/p/augustinus-bader/the-serum/for/mature-skin) — High fit — A$639.95 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/au/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — A$73.61 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/au/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — A$37.00 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/au/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — A$116.08 at Amazon

## Where to buy

- Amazon.com.au: A$89.00 (https://www.amazon.com.au/dp/B0BV3F1X4H?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)
Prices checked 31 Oct 2026.

## Ingredients

Water, Glycerin, Peg-8 Dimethicone, Tripeptide-1, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Hexapeptide-12, Myristoyl Hexapeptide-16, Myristoyl Pentapeptide-17, Hexanoyl Dipeptide-3 Norleucine Acetate, Azelaoyl Bis-Dipeptide-10, Glycoproteins, Adenosine, Dipotassium Glycyrrhizate, Arginine, Valine, Glycine, Alanine, Glutamic Acid, Serine, Threonine, Yeast Extract, Isoleucine, Proline, Histidine, Phenylalanine, Pca, Phytic Acid, Panax Ginseng Root Extract, Sodium Pca, Psidium Guajava Fruit Extract, Euterpe Oleracea Fruit Extract, Ahnfeltiopsis Concinna Extract, Dextran, Hydrolyzed Silk, Lecithin, Glyceryl Polymethacrylate, C12-16 Pareth-9, Trideceth-12, Sodium Lactate, Carbomer, Aspartic Acid, Polysorbate 20, Butylene Glycol, Caprylyl Glycol, C11-15 Pareth-7, Guar Hydroxypropyltrimonium Chloride, Phytosteryl Octyldodecyl Lauroyl Glutamate, Ectoin, Citrate Buffer, Trimethylsiloxyamodimethicone, Phenoxyethanol, Sodium Hydroxide, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/peptide-booster/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/peptide-booster/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/paula-s-choice/peptide-booster/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/paula-s-choice/peptide-booster/for/mature-skin
- France: https://lovi.care/skincare/fr/p/paula-s-choice/peptide-booster/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/paula-s-choice/peptide-booster/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/paula-s-choice/peptide-booster/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/paula-s-choice/peptide-booster/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/paula-s-choice/peptide-booster/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/paula-s-choice/peptide-booster/for/mature-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/paula-s-choice/peptide-booster/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/paula-s-choice/peptide-booster/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/paula-s-choice/peptide-booster/for/mature-skin