numbuzin No.3 Super Glowing Essence Toner for skin with dark spots

How to apply

Questions and answers

What the research says

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women.

  Scientific Reports, 2024

• Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG.

  Drug Delivery, 2017

• Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated.

  Antioxidants, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.

  Journal of Cosmetic and Laser Therapy, 2006

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Probiotic-derived lotion successfully reduced inflammatory acne lesion counts and erythema index comparably to 2.5% benzoyl peroxide in patients with mild-to-moderate acne vulgaris, while causing fewer side effects.

  Journal of Cosmetic Dermatology, 2022

• Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers.

  International Journal of Medical Sciences, 2021

• Lactobacillus plantarum extracellular vesicles modulated extracellular matrix related gene expression in vitro and suppressed wrinkle formation and pigmentation in clinical trials.

  Current Issues in Molecular Biology, 2022

• Chemical profiling and in vitro screening of Filipendula ulmaria extract and centrifugal partition chromatography fractions on Normal Human Epidermal Keratinocytes identified 28 compounds, with specific fractions upregulating genes related to skin barrier function, epidermal renewal, and stress responses.

  Molecules, 2023

Ingredients

Water, Dipropylene Glycol, Glycereth-26, 1,2-Hexanediol, Niacinamide, Butylene Glycol, Glycerin, Methyl Gluceth-20, Spiraea Ulmaria Extract, Lactococcus Bean Seed Extract Ferment Filtrate, Lactobacillus Ferment, Chlorella Ferment, Lactobacillus Algae Extract Ferment, Saccharomyces Grape Extract Ferment, Lactobacillus Pumpkin Extract Ferment, Lactobacillus Soybean Extract Ferment, Lactobacillus Soybean Extract Ferment Filtrate, Saccharomyces Rice Ferment Filtrate, Saccharomyces Barley Seed Ferment Filtrate, Saccharomyces Calcium Ferment, Saccharomyces Potato Extract Ferment Filtrate, Lactobacillus Eriodictyon Californicum Extract Ferment, Lactobacillus Water Hyacinth Ferment, Lactobacillus Rye Flour Ferment, Lactobacillus Hibiscus Sabdariffa Flower Ferment Filtrate, Lactobacillus Milk Ferment Filtrate, Lactobacillus Panax Ginseng Root Ferment Filtrate, Lactobacillus Acerola Cherry Ferment, Lactobacillus Lysate Ferment, Lactococcus Lysate Ferment, Streptococcus Thermophilus Ferment, Aureobasidium Pullulans Ferment, Bifida Ferment Filtrate, Leuconostoc Radish Root Ferment Filtrate, Lactobacillus Wasabia Japonica Extract Root Ferment, Lactobacillus Punica Granatum Extract Fruit Ferment, Glutamic Acid, Bacillus Rice Soybean Bran Extract Extract Ferment Filtrate, Monascus Rice Ferment, Saccharomyces Rice Bran Ferment, Lactobacillus Pear Juice Ferment Filtrate, Pichia Lysate Ferment Filtrate, Alteromonas Extract Ferment, Saccharomyces Soy Ferment Protein, Saccharomyces Ferment, Aspergillus Ferment, Aspergillus Glucose Soybean Ferment Filtrate Starch, Pelargonium Graveolens Oil Flower, Sodium Hyaluronate, Polyglyceryl-10 Laurate, Cetearyl Alcohol, Betaine, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Tromethamine, Polyquaternium-51, Hydroxyethylcellulose, Adenosine, Geraniol, Citronellol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.