# Numbuzin No.2 Protein 43% Creamy Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/au/p/numbuzin/no-2-protein-43-creamy-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [Numbuzin](https://lovi.care/skincare/au/brands/numbuzin)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/au/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Highly suitable for your normal skin, this serum utilizes multiple protein ingredients like Oat Extract Protein and Rice Seed Protein to provide excellent barrier repair and emollient actions, offering great hydration and elasticity.
- While it addresses general skincare needs effectively, it lacks specialized ingredients to directly target your wrinkles and fine lines, meaning its benefits for collagen production or wrinkle reduction are supportive rather than primary.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components like hydrolyzed corn protein and hydrolyzed milk protein.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/numbuzin/no-2-protein-43-creamy-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/au/p/numbuzin/no-2-protein-43-creamy-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/au/p/numbuzin/no-2-protein-43-creamy-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/au/p/numbuzin/no-2-protein-43-creamy-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/au/p/numbuzin/no-2-protein-43-creamy-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/au/p/numbuzin/no-2-protein-43-creamy-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/au/p/numbuzin/no-2-protein-43-creamy-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/au/p/numbuzin/no-2-protein-43-creamy-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/numbuzin/no-2-protein-43-creamy-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Content Protein, Rice Seed Protein, Hydrolyzed Protein, Ceramide Np, Cholesterol

## What the research says

- Rice protein hydrolysate and its characteristic peptides Leu-Leu-Lys, Leu-Pro-Lys, and pyroGlu-Lys reduced melanin content, tyrosinase activity, and ROS production in UVB-induced human epidermal melanocyte PIG1 cells by regulating the JNK/Β-Trcp/NFΗB-p65/MITF signaling pathway and lowering TRP-1 and TRP-2 expression. ([Food & Function, 2020](https://pubmed.ncbi.nlm.nih.gov/32955075/))
- A liquid formulation containing hydrolyzed collagen demonstrated structural stability, peptide mass distribution between 0.5 and 19.5 kDa, and faded forehead wrinkles in five volunteers while proving to be non-irritating and hypoallergenic. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32390321/))
- Combined treatment with human umbilical cord mesenchymal stem cell-derived exosomes and hydrolyzed collagen oligopeptides enhanced proliferation and migration, reduced reactive oxygen species and senescence-associated beta-galactosidase activity, increased type I and type III collagen expression, and decreased metalloproteinases, inflammatory cytokines, and senescence markers in human skin fibroblasts compared to either treatment alone. ([Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611748/))
- Collagen peptides induced cell proliferation and pro-collagen-1α expression, increased TGF-β and VEGF, and suppressed the LPS-induced inflammatory response in human skin fibroblasts and keratinocytes. ([Nutrients, 2022](https://pubmed.ncbi.nlm.nih.gov/36501011/))
- Botulinum toxin-A encapsulated in phosphatidylcholine/cholesterol nanoliposomes delivered transdermally achieved a diffusion depth of 380 μm and showed a nonsignificant advantage in relieving post-acne scarring compared to hyaluronic acid hydrogel treatment in 12 facial patients. ([Journal of Materials Science. Materials in Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/39073502/))
- Topical application of cholesterol sulfate increases stratum corneum thickness and inhibits protease-induced cell dissociation by competitively inhibiting serine proteases in mice and human stratum corneum. ([The Journal of Investigative Dermatology, 1998](https://pubmed.ncbi.nlm.nih.gov/9699715/))
- Topical lovastatin treatment impairs the recovery of cutaneous permeability barrier function and stratum corneum cholesterol levels after acetone disruption in mice, an effect normalized by simultaneous treatment with mevalonate or cholesterol. ([The Journal of Clinical Investigation, 1990](https://pubmed.ncbi.nlm.nih.gov/2243142/))

## What reviewers say

This serum is widely praised as a "winter savior" for dry, sensitive, and dehydrated skin, effectively repairing damaged barriers and alleviating flakiness. Users consistently report a plump, healthy glow and deep "inner" hydration, though its rich, protein-heavy formula can be too heavy or potentially pore-clogging for oily or acne-prone skin types.

- Liked: Deep barrier repair (mostly mentioned)
- Liked: Long-lasting hydration (often mentioned)
- Liked: Rich creamy texture (often mentioned)
- Liked: Glowy finish (sometimes noted)
- Disliked: Not for oily skin (sometimes noted)
- Disliked: Potential breakouts (sometimes noted)
- Disliked: Stickiness/tackiness (sometimes noted)
- Disliked: Packaging issues (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Numbuzin No.2 Protein 43% Creamy Serum a great fit for mature skin?

This serum is a great fit for mature skin because it uses multiple proteins like oat and rice seed protein to repair your skin barrier, giving you great hydration and smooth elasticity. It also includes soothing ingredients and ceramides that are very gentle on your skin without any risk of irritation.

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit because it uses multiple protein ingredients like Oat Extract Protein and Rice Seed Protein, along with Ceramide Np and Cholesterol. These ingredients help repair your skin barrier, keep it soft, and provide great hydration and elasticity for mature skin.

### What does Content Protein do for mature skin?

Content Protein helps keep mature skin soft and hydrated by improving moisture levels and skin elasticity. Regular use may also reduce roughness and support natural hydration factors to keep your skin smooth.
Sources: [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26362110/), [Nutrients, 2021](https://pubmed.ncbi.nlm.nih.gov/34959923/)

### What does Rice Seed Protein do for mature skin?

Rice Seed Protein helps hydrate and smooth mature skin while keeping it soft and firm. It may support skin elasticity and reduce the look of fine lines with regular use.

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine as a treatment step, applied after cleansing and before moisturizing. Putting it in the evening routine offers simplicity and extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum before your retinol product to help keep your skin comfortable. Barrier-strengthening ingredients like ceramides and proteins help support your skin and make it easier to tolerate retinoids.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this serum?

You can use this serum in your evening routine, applying it after cleansing and before your moisturizer. It is gentle enough for daily use and helps keep mature skin soft and well-hydrated.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum has a moderate likelihood of causing breakouts for some users, even though it is generally very safe and gentle on mature skin. Because it is rich and moisturizing, it is best for dry skin and may feel too heavy if your skin tends to get oily or clogged easily.

### Can I use this serum around the eyes or on my body?

You can use this serum around the eyes and on the body because its gentle formula has an excellent safety profile with soothing ingredients that are unlikely to cause irritation. The thin skin in these areas benefits greatly from its rich protein and ceramide blend, which helps keep the skin feeling soft and smooth.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Revision Skincare Hydrating Serum](https://lovi.care/skincare/au/p/revision-skincare/hydrating-serum/for/mature-skin) — High fit — A$97.29 at Amazon
- [Isntree Green Tea Fresh Serum](https://lovi.care/skincare/au/p/isntree/green-tea-fresh-serum/for/mature-skin) — High fit — A$34.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/au/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — A$73.61 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/au/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — A$37.00 at Amazon
- Pre-Cleanser: [Pyunkang Yul Deep Cleansing Oil](https://lovi.care/skincare/au/p/pyunkang-yul/deep-cleansing-oil/for/mature-skin) — Superior fit — A$30.99 at Amazon

## Where to buy

No store in Australia has a checked price for this product, so the page shows none.

## Ingredients

Voat Extract Protein, Water, Cyclopentasiloxane, Butylene Glycol, Cetearyl Ethyl Hexanoate, Cyclohexasiloxane, Phenyl Trimethicone, Cetyl Pg, Sebum-10 1 Dimethicone, Hydrogenate Tid Poly, Rice Seed Protein, Prunus Amygdalus Dulcis Protein, Hydrolyzed Corn Protein, Hydrolyzed Protein, Hydrolyzed Pea Protein, Hydrolyzed Milk Protein, Glycine Soja Protein Soybean Protein, Hydrolyzed Lupine Protein, Ceramide Np, Cholesterol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/numbuzin/no-2-protein-43-creamy-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/numbuzin/no-2-protein-43-creamy-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/numbuzin/no-2-protein-43-creamy-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/numbuzin/no-2-protein-43-creamy-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/numbuzin/no-2-protein-43-creamy-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/numbuzin/no-2-protein-43-creamy-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/numbuzin/no-2-protein-43-creamy-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/numbuzin/no-2-protein-43-creamy-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/numbuzin/no-2-protein-43-creamy-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/numbuzin/no-2-protein-43-creamy-serum/for/mature-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/numbuzin/no-2-protein-43-creamy-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/numbuzin/no-2-protein-43-creamy-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/numbuzin/no-2-protein-43-creamy-serum/for/mature-skin