# NATURIUM Niacinamide Serum 12% Plus Zinc 2% for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/au/p/naturium/niacinamide-serum-12-plus-zinc-2/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [NATURIUM](https://lovi.care/skincare/au/brands/naturium)
Category: [Serums and treatments](https://lovi.care/skincare/au/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your oily skin and acne concerns is provided by high concentrations of niacinamide and zinc PCA, which effectively regulate oil production and reduce inflammation.
- Sodium hyaluronate and glycerin further support hydration without clogging pores, complementing the primary actives for balanced skin.
- The formula is safe for your skin, featuring soothing ingredients and avoiding harsh components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/naturium/niacinamide-serum-12-plus-zinc-2/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/au/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/au/p/naturium/niacinamide-serum-12-plus-zinc-2/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/au/p/naturium/niacinamide-serum-12-plus-zinc-2/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/au/p/naturium/niacinamide-serum-12-plus-zinc-2/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/au/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/au/p/naturium/niacinamide-serum-12-plus-zinc-2/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/au/p/naturium/niacinamide-serum-12-plus-zinc-2/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/naturium/niacinamide-serum-12-plus-zinc-2/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Niacinamide, Zinc Pca, Sodium Hyaluronate, Tocopheryl Acetate Vitamin E, Glycerin

## What the research says

- Topical nicotinamide plus an antibacterial adhesive agent and zinc-pyrrolidone carboxylic acid combined with adapalene significantly reduced noninflammatory acne lesions by the second week of therapy compared to placebo with adapalene in patients with moderate acne vulgaris. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Zinc PCA inhibits UVA-induced matrix metalloproteinase-1 production through suppressed AP-1 activation and enhances type I collagen synthesis by increasing SVCT2 mRNA expression in cultured normal human dermal fibroblasts. ([International Journal of Cosmetic Science, 2012](https://pubmed.ncbi.nlm.nih.gov/21834944/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- A topical antioxidant serum significantly reduced air pollution-induced skin pigmentation and proinflammatory gene expression ex vivo, and improved skin aging signs in 40 healthy adult females after 90 days of daily use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35150043/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, this serum is highly effective for oily and acne-prone skin, with users frequently reporting minimized pores, controlled oil production, and smoother skin texture. Some users, particularly those with sensitive skin, experience irritation, stinging, or breakouts due to the high concentration of niacinamide. A small number of users also noted a sticky residue or saw no visible results.

- Liked: Controls oil (mostly mentioned)
- Liked: Lightweight, absorbs fast (often mentioned)
- Liked: Minimizes pores (often mentioned)
- Liked: Smooths texture (often mentioned)
- Liked: Brightens tone (sometimes noted)
- Disliked: Causes breakouts (sometimes noted)
- Disliked: Too strong (sometimes noted)
- Disliked: Causes irritation (rarely noted)
- Disliked: No results (rarely noted)
- Disliked: Sticky residue (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Naturium Niacinamide Serum a great fit for oily acne-prone skin?

This serum is a great fit because high concentrations of niacinamide and zinc PCA help control excess oil and calm breakouts. Ingredients like glycerin and sodium hyaluronate add lightweight moisture so your skin stays balanced without feeling greasy or clogged.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

This serum is a great fit because high concentrations of niacinamide and zinc PCA help regulate oil production and calm inflammation, while sodium hyaluronate and glycerin keep skin hydrated without clogging pores. These ingredients work together to give oily and acne-prone skin a balanced, smooth feel.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/)

### What does Niacinamide do for oily acne-prone skin?

Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/)

### What does Zinc PCA do for oily acne-prone skin?

Zinc PCA helps calm oily, acne-prone skin by reducing excess oil and targeting the bacteria that cause breakouts. This ingredient has a great safety profile and is unlikely to irritate your skin while helping to keep pores clear.
Sources: [The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/), [Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23652948/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing, helping to keep oil production under control and soothe blemishes. Using it at night also helps keep your skin safe from extra sun sensitivity.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the treatment after cleansing and before your moisturizer, usually in your evening routine. This helps control oil and calm your skin while keeping hydration balanced without clogging pores.
Sources: [The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/)

### How often should I use this serum?

This serum fits well in your evening routine and is safe to use once a day. Niacinamide and zinc PCA help regulate oil production and reduce inflammation, while ingredients like sodium hyaluronate keep your skin hydrated.
Sources: [The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/)

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is a great fit for your oily, acne-prone skin because high concentrations of niacinamide and zinc PCA help regulate oil and calm inflammation, while sodium hyaluronate and glycerin keep skin hydrated without clogging pores. The formula is generally safe and unlikely to cause breakouts or purging, though some reviewers have reported mild breakouts or irritation because active products can sometimes feel too strong.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/au/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — A$16.95 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/au/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — A$50.60 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/au/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — A$50.60 at Amazon

## Pairs well with

- Cleanser: [Paula's Choice CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/au/p/paula-s-choice/clear-pore-normalizing-cleanser/for/oily-acne-prone-skin) — Superior fit — A$32.00 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/au/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — A$42.00 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/au/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — A$22.99 at Amazon

## Where to buy

No store in Australia has a checked price for this product, so the page shows none.

## Ingredients

Water, Niacinamide, Propanediol, Glycerin, Zinc Pca, Polyacrylate Crosspolymer-11, Sodium Hyaluronate, Dimethicone, Caprylyl Glycol, Phenoxyethanol, Xanthan Gum, Potassium Sorbate, Glyceryl Polyacrylate, Tocopheryl Acetate, Hexylene Glycol, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/naturium/niacinamide-serum-12-plus-zinc-2/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/naturium/niacinamide-serum-12-plus-zinc-2/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/naturium/niacinamide-serum-12-plus-zinc-2/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/naturium/niacinamide-serum-12-plus-zinc-2/for/oily-acne-prone-skin
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- Netherlands: https://lovi.care/skincare/nl/p/naturium/niacinamide-serum-12-plus-zinc-2/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/naturium/niacinamide-serum-12-plus-zinc-2/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/naturium/niacinamide-serum-12-plus-zinc-2/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/naturium/niacinamide-serum-12-plus-zinc-2/for/oily-acne-prone-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/naturium/niacinamide-serum-12-plus-zinc-2/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/naturium/niacinamide-serum-12-plus-zinc-2/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/naturium/niacinamide-serum-12-plus-zinc-2/for/oily-acne-prone-skin