Natura Bissé C+C Vitamin Complex for combination skin
Ascorbic Acid
Vitamin E
Rosa Canina Oil Fruit
Hydrolyzed CollagenAverage
- HighCombination Skin Fit
- AverageEffectiveness
- HighSafety
Works for combination skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate skin brightening for your combination skin due to Sodium Ascorbyl Phosphate, which helps even skin tone, while Glycerin provides hydration that is not optimal for oily shine.
- Hydrolyzed Collagen and Rosa Canina Oil Fruit offer general skincare benefits and hydration, but lack sufficient ingredients for effective oil control on your oily shine.
- The product is safe for your combination skin, with no risks of irritation from harsh ingredients and the inclusion of soothing agents like Tocopherol.
How to apply
- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
People Say
★4.5Overall rating based on 100+ reviewsBased on limited data, users consistently praise this serum for its potent brightening abilities, noting that it effectively revitalizes dull, tired-looking skin and improves overall radiance. The lightweight, fast-absorbing texture is a hit, though some users with sensitive skin caution against potential irritation due to the high concentration of Vitamin C and strong citrus fragrance.
Highlights
Brightens dull skin Often Mentioned
- “Instant glow”
- “revitalizes complexion”
- “looks less tired”
- “radiant finish”
High price Often Mentioned
- “Very expensive”
- “pricey investment”
- “luxury cost”
- “wallet hurting”
Lightweight texture Sometimes Noted
- “Absorbs immediately”
- “non-greasy”
- “silky feel”
- “light fluid”
Pleasant scent Sometimes Noted
- “Fresh citrus smell”
- “smells like oranges”
- “uplifting fragrance”
- “energizing scent”
Potential irritation Sometimes Noted
- “Stung slightly”
- “redness on application”
- “too strong for sensitive skin”
- “tingling sensation”
Firming effect Rarely Noted
- “Skin feels tighter”
- “improves elasticity”
- “plumper look”
- “smoother texture”
Availability issues Rarely Noted
- “Hard to find”
- “often out of stock”
- “discontinued in some stores”
- “confusing product name”
Strong fragrance Rarely Noted
- “Scent is overpowering”
- “too much perfume”
- “fragrance lingers”
- “smell is intense”
Sources: lovi.care, nordstrom.com, dermstore.com, bloomingdales.com, influenster.com, whatsinmyjar.com, and more
Questions and answers
How well does Natura Bissé C+C Vitamin Complex work for combination skin?
Natura Bissé C+C Vitamin Complex is an average fit for combination skin because it offers moderate brightening and hydration, but it lacks sufficient ingredients for effective oil control. A treatment for this skin needs ingredients like niacinamide, propolis, or zinc PCA to provide balanced hydration and regulate oiliness without any risk of irritation.
Which ingredients make this treatment a good fit for combination skin?
Sodium Ascorbyl Phosphate helps even skin tone and reduce oily shine, while Glycerin provides light hydration. To truly fit combination skin, a treatment of this type needs ingredients like niacinamide and zinc PCA to properly balance oiliness and maintain skin health.
Drug Research, 2017Clinical, Cosmetic and Investigational Dermatology, 2017
What does Vitamin C do for combination skin?
Vitamin C helps brighten dull areas and smooth out uneven texture on combination skin while protecting against daily environmental stress. It may also help keep pores clear and skin firm by supporting collagen production, though drier spots may need an added moisturizer to stay comfortable.
Journal of Cosmetic Dermatology, 2020Journal of Cosmetic Dermatology, 2023
What does Vitamin E do for combination skin?
Vitamin E helps balance combination skin by boosting moisture while calming redness and reducing oiliness in shiny areas. It is generally well-tolerated and may help protect the skin barrier, keeping both dry and oily patches comfortable and smooth.
Journal of Cosmetic Dermatology, 2024Journal of Cosmetic Dermatology, 2020
Where does this treatment go in a skincare routine for combination skin?
This treatment goes in the evening routine after cleansing and before moisturizing, though some treatments can also be used in the morning or twice a day. For combination skin, a product of this type needs ingredients that brighten skin while offering effective oil control.
Can I use this treatment with retinol, and in what order?
You can use this treatment with retinol by applying your retinol first and following with this treatment, or by using retinol at night and this treatment in the morning to avoid overloading your skin. This product helps brighten tone and provides hydration, but combination skin works best with products that also offer targeted oil control.
How often should I use this treatment?
You can use this treatment in the evening as part of your routine for combination skin. To keep your skin balanced, a product of this type needs targeted oil-control ingredients and hydration that manages oily shine.
Can this treatment clog pores, cause breakouts or purging for combination skin?
This treatment is unlikely to clog pores or cause breakouts on combination skin, as it has a safe profile with soothing ingredients like Tocopherol and no harsh irritants. However, to better manage oily shine, combination skin needs products with effective oil-control ingredients.
Is this treatment fragrance-free and alcohol-free?
It has no drying alcohol and contains fragrance (parfum, limonene, and linalool).
What the research says
Combined ascorbyl palmitate and sodium ascorbyl phosphate treatment significantly reduced facial sebum secretions in healthy female volunteers compared to a placebo control over 90 days.
Drug Research, 2017The tetrapeptide PKEK exerts skin whitening effects by reducing UVB-stimulated mRNA expression of pigmentation-inducing mediators like POMC and tyrosinase, and significantly fades facial pigment spots when combined with sodium ascorbyl phosphate.
Experimental Dermatology, 2012A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.
Journal of Cosmetic Dermatology, 2025Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.
Contemporary Clinical Trials Communications, 2021Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.
Journal of Cosmetic Dermatology, 2024Topical treatments containing rosehip extract may reduce the size and erythema of postsurgical scars through macrophage polarization and inflammatory cytokine inhibition, though current clinical evidence remains insufficient to recommend its routine use.
Journal of Cosmetic Dermatology, 2024Sunflower and rosehip oil nanoemulsions prepared with a mix of phospholipids and synthetic emulsifiers permeated intact skin to the dermis and showed a more prominent healing effect in a human organotypic skin explant culture wound model compared to nanoemulsions prepared only with phospholipids.
Pharmaceutics, 2023A nanoemulsion containing 1 mg/mL kojic dipalmitate and 5% rosehip oil demonstrated high incorporation efficiency, suitable physicochemical stability, antioxidant and depigmenting efficacy close to 1 mM ascorbic acid, and no cytotoxicity at concentrations from 0.06% to 1% in vitro.
Pharmaceutics, 2023Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris.
Journal of Cosmetic Dermatology, 2022Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks.
International Journal of Molecular Sciences, 2022Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers.
Marine Drugs, 2023
Why other serums fit combination skin better
Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo.
BioMed Research International, 2022A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions.
Journal of Cosmetic Dermatology, 2024
Ingredients
Water, Sodium Ascorbyl Phosphate, Sodium Acrylates Copolymer, Propanediol, Glycerin, Hydrogenated Polyisobutene, Rosa Canina Oil Fruit, Hydrolyzed Opuntia Ficus-Indica Flower Extract, Citric Acid, Tocopheryl Acetate, Anogeissus Leiocarpus Bark Extract, Helianthus Annuus Seed Oil Sunflower Seed Oil, Hydrolyzed Collagen, Sodium Chondroitin Sulfate, Prunus Amygdalus Dulcis Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Polysorbate 60, Sorbitan Stearate, Disodium Edta, Tocopherol, Potassium Sorbate, Phenoxyethanol, Parfum, Limonene, Linalool, Citrus Nobilis Oil Mandarin Orange Oil, Citrus Aurantium Dulcis Oil, Amyl Cinnamal, Yellow 5 Ci 19140
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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