# Medimine Phyto Enzyme Powder Wash for acne-prone skin

**Lovi Fit: Superior fit for acne-prone skin.**
Combination Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/au/p/medimine/phyto-enzyme-powder-wash/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: Medimine
Category: [Exfoliants](https://lovi.care/skincare/au/best/exfoliators)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best products for acne-prone skin.

## Why this fit

- Excellent suitability for your combination skin and acne, blemishes, and breakouts is provided by papain and niacinamide, which offer targeted enzymatic exfoliation and pore-clearing effects to balance oil production and reduce inflammation.
- The presence of soothing ingredients like Chamomilla Recutita Flower Extract and Glycyrrhiza Glabra Root Extract further supports skin health by calming irritation and promoting a clearer complexion.
- This formula is safe for your acne-prone skin, as it contains no harsh ingredients and includes beneficial extracts that minimize irritation risk.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/medimine/phyto-enzyme-powder-wash/for/oily-skin): Superior
- [Dry skin](https://lovi.care/skincare/au/p/medimine/phyto-enzyme-powder-wash/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/au/p/medimine/phyto-enzyme-powder-wash/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/au/p/medimine/phyto-enzyme-powder-wash/for/sensitive-skin): Superior
- [Acne-prone skin](https://lovi.care/skincare/au/p/medimine/phyto-enzyme-powder-wash/for/acne-prone-skin): Superior (this page)
- [Skin with dark spots](https://lovi.care/skincare/au/p/medimine/phyto-enzyme-powder-wash/for/dark-spots): Superior
- [Mature skin](https://lovi.care/skincare/au/p/medimine/phyto-enzyme-powder-wash/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/au/p/medimine/phyto-enzyme-powder-wash/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/medimine/phyto-enzyme-powder-wash/for/oily-acne-prone-skin): Superior

## Key ingredients

Papain, Pearl Extract, Niacinamide, Licorice Root Extract, Chamomile Flower Extract

## What the research says

- A fixed combination of hydroxypinacolone retinoate, retinol glycospheres, and papain glycospheres in aqueous gel applied once daily for 12 weeks achieved a 41% mean reduction in GAGS score and a 40.8% mean reduction in total lesions, with 15.3% of patients experiencing mild to moderate local side effects, in 94 evaluable patients with comedonal-papular, mild to moderate acne of the face. ([Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/))
- Apigenin protects against UVA-induced cytotoxicity and senescence in normal human dermal fibroblasts, decreases MMP-1 expression, and when applied topically as a cream in human subjects, increases dermal density and elasticity while reducing fine wrinkle length, skin evenness, moisture content, and transepidermal water loss compared to control cream. ([International Journal of Molecular Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/27279007/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Combining pearl extract and poly (γ-glutamic acid) hydrogels with UVB irradiation decreases inflammation and apoptosis in human keratinocyte HaCaT cells without toxic effects compared to UVB irradiation alone. ([Bio-medical Materials and Engineering, 2015](https://pubmed.ncbi.nlm.nih.gov/26405901/))
- Topical papain treatment may slightly decrease pain within 30 minutes in humans stung by Chrysaora chinensis compared to placebo. ([Wilderness & Environmental Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/26827260/))
- Reflux extraction of Carica papaya leaves yielded higher antioxidant capacity and superior in vitro wound-healing activities including fibroblast proliferation, cell migration, and collagen synthesis in human skin fibroblasts compared to ultrasonic-assisted extraction and agitation. ([Molecules, 2020](https://pubmed.ncbi.nlm.nih.gov/31991676/))
- Carica papaya leaf extracts obtained via supercritical fluid and conventional methods demonstrated antioxidant and cytoprotective effects on skin fibroblasts against oxidative stress, driven by their respective lipophilic and hydrophilic constituents. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/33803330/))
- Micro and nanosized pearl powders increased skin cell proliferation and migration, accelerated wound closure, enhanced biomechanical strength, improved collagen deposition, and promoted angiogenesis in rats, with nanoscale pearl powder showing the highest efficiency. ([Drug Development and Industrial Pharmacy, 2019](https://pubmed.ncbi.nlm.nih.gov/30950303/))
- Topical pearl extract gel inhibited UV-irritated skin wrinkles, laxity, thickness, and dryness, upregulated antioxidant enzyme activities, decreased MDA levels, and suppressed inflammatory factors in UV-irradiated mice compared to untreated controls, with high-dose PEG showing superior effects to Vitamin E. ([Chemistry & Biodiversity, 2022](https://pubmed.ncbi.nlm.nih.gov/35098641/))
- Seawater pearl powder treatment significantly improves UV-induced photoaging and restores skin tissue structure in mice by reducing MMP-1, enhancing collagen I, inhibiting the MAPK signaling pathway, and scavenging reactive oxygen species. ([Evidence-based Complementary and Alternative Medicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34925534/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical application of Glycyrrhiza glabra and Sophora japonica flavonoid-rich fractions individually and in combination significantly increased the wound healing rate and reduced oxidative stress compared to wound and Nolaver-treated groups. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37049756/))
- Topical chamomile oil combined with a night splint significantly improved the symptomatic and functional status of patients with severe carpal tunnel syndrome compared to placebo, while electrodiagnostic parameters showed no significant changes. ([Complementary Therapies in Clinical Practice, 2015](https://pubmed.ncbi.nlm.nih.gov/26573447/))
- German chamomile solution applied twice a day healed peristomal skin lesions significantly faster than once-a-day 1% hydrocortisone ointment in colostomy patients, with a mean healing time of 8.89 days versus 14.53 days. ([Ostomy/wound Management, 2011](https://pubmed.ncbi.nlm.nih.gov/21617262/))
- Topical chamomile reduces the incidence and delays the occurrence of phlebitis due to amiodarone infusion in coronary care patients compared to a placebo of lanoline. ([Journal of Integrative Medicine, 2017](https://pubmed.ncbi.nlm.nih.gov/28844214/))

## What reviewers say

Based on limited data, users generally praise this powder wash for its ability to dramatically improve skin texture and brightness without causing tightness, often describing it as a "holy grail" for smoothing rough skin. However, experiences are polarized regarding sensitivity; while many find it gentle, a minority report significant irritation and redness, and some struggle with the powder packaging.

- Liked: Smoothes skin texture (mostly mentioned)
- Liked: Brightening effect (often mentioned)
- Liked: Non-stripping (often mentioned)
- Liked: Clears bumps/acne (sometimes noted)
- Disliked: Packaging issues (sometimes noted)
- Disliked: High price (rarely noted)
- Disliked: Makeup removal (rarely noted)
- Disliked: Potential irritation (rarely noted)

## How to apply

- Use your enzyme powder cleanser as part of your PM weekly routine. Start by using it once a week and build up slowly if your skin is happy.
- Place this step after your regular cleanser and before applying your hydrating toner. Follow the weekly routine order for the best results.
- Mix the powder with a little water in your hands to create a soft foam. Gently massage onto your face and avoid rubbing too hard.
- Apply the enzyme powder cleanser on slightly damp skin to help activate the formula evenly. Make sure your face is clean before applying.
- Avoid the sensitive eye area during application. Do a patch test first and do not combine this with strong acids on the same night.
- Video: https://storage.pora.ai/2d8db6e67371d665a6a7736b5ed5d762.mp4

## Questions and answers

### What makes Medimine Phyto Enzyme Powder Wash one of the best fits for acne-prone skin?

Medimine Phyto Enzyme Powder Wash is an exceptional fit for acne-prone skin because papain and niacinamide provide gentle, targeted exfoliation to clear pores, balance oil, and calm redness. Soothing extracts like licorice root and chamomile further help reduce irritation and support a clearer, more balanced complexion with a low risk of trouble.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/), [Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/)

### Which ingredients make this cleanser a good fit for acne-prone skin?

Papain and niacinamide make this cleanser a great fit for acne-prone skin because they gently clear out pores and balance oil to help reduce breakouts. Soothing plant extracts like chamomile and licorice root also calm irritation and keep skin looking clear.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/), [Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/)

### What does Papain do for acne-prone skin?

Papain helps clear acne-prone skin by gently removing dead cells and targeting blemishes as part of a targeted treatment gel used daily. However, it may cause mild redness or irritation, and since it can disrupt the skin barrier, acne-prone skin also needs soothing, barrier-repairing ingredients to stay calm and protected.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/), [The Journal of Investigative Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25705851/)

### What does Pearl Extract do for acne-prone skin?

Pearl extract helps calm red and irritated acne-prone skin by lowering inflammation and protecting skin cells from damage. It is unlikely to cause harsh reactions, making it gentle for troubled skin.
Sources: [Bio-medical Materials and Engineering, 2015](https://pubmed.ncbi.nlm.nih.gov/26405901/)

### Where does this cleanser go in a skincare routine for acne-prone skin?

This enzyme powder cleanser goes in your weekly routine as an exfoliating step, starting at once a week and carefully increasing only if your skin tolerates it well. It fits right after your makeup remover in the weekly routine for acne-prone skin, helping to clear pores and balance oil production safely without harsh ingredients.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use this cleanser with retinol, and in what order?

You can use this cleanser in the same routine as retinol, but it is best to use them on alternate days or times to prevent irritation. Since this powder wash provides gentle enzymatic exfoliation, using it at a different time than your retinol helps keep your skin calm and clear.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/), [American Family Physician, 2012](https://pubmed.ncbi.nlm.nih.gov/23062156/)

### How often should I use this cleanser?

Start by using this enzyme powder cleanser once a week as part of your routine. If your skin tolerates it well and you see good results, you may carefully use it more often.

### Can this cleanser clog pores, cause breakouts or purging for acne-prone skin?

This cleanser is unlikely to clog pores or cause breakouts for acne-prone skin because it contains gentle cleansing agents and soothing extracts that help calm irritation. The papain and niacinamide also offer targeted exfoliation and pore-clearing effects to balance oil production and reduce inflammation safely.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/), [Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/)

### Is this cleanser fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Dr. Barbara Sturm Enzyme Cleanser](https://lovi.care/skincare/au/p/dr-barbara-sturm/enzyme-cleanser/for/acne-prone-skin) — High fit — A$114.68 at Amazon
- [By Wishtrend Green Tea & Enzyme Powder Wash](https://lovi.care/skincare/au/p/by-wishtrend/green-tea-and-enzyme-powder-wash/for/acne-prone-skin) — High fit — A$38.38 at Amazon
- [Tatcha The Rice Polish: Deep](https://lovi.care/skincare/au/p/tatcha/the-rice-polish-deep/for/acne-prone-skin) — Average fit — A$113.00 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/au/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — A$13.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/au/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — A$34.66 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/au/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — A$24.00 at Amazon

## Where to buy

No store in Australia has a checked price for this product, so the page shows none.

## Ingredients

Zea Mays Starch, Sodium Cocoyl Isethionate, Sodium Lauroyl Glutamate, Sorbitol, Papain, Pearl Extract, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Allantoin, Citric Acid, Disodium Edta, Isopropyl Palmitate, Niacinamide, Betaine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medimine/phyto-enzyme-powder-wash/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medimine/phyto-enzyme-powder-wash/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/medimine/phyto-enzyme-powder-wash/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/medimine/phyto-enzyme-powder-wash/for/acne-prone-skin
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- Italy: https://lovi.care/skincare/it/p/medimine/phyto-enzyme-powder-wash/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/medimine/phyto-enzyme-powder-wash/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/medimine/phyto-enzyme-powder-wash/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/medimine/phyto-enzyme-powder-wash/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/medimine/phyto-enzyme-powder-wash/for/acne-prone-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/medimine/phyto-enzyme-powder-wash/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medimine/phyto-enzyme-powder-wash/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medimine/phyto-enzyme-powder-wash/for/acne-prone-skin