# Medik8 Oxy-R Peptides for mature skin

**Lovi Fit: Superior fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/au/p/medik8/oxy-r-peptides/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [Medik8](https://lovi.care/skincare/au/brands/medik8)
Category: [Serums and treatments](https://lovi.care/skincare/au/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for mature skin.

## Why this fit

- Excellent for normal skin, this formula leverages Hydroxyresveratrol and Tetrapeptide-30 to effectively target wrinkles and fine lines by promoting collagen synthesis and skin elasticity. Gluconolactone further aids in refining skin texture with its mild keratolytic action.
- Glycerin and Sodium Hyaluronate provide excellent hydration, ensuring comfort and supporting the skin's barrier function without irritation.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/medik8/oxy-r-peptides/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/au/p/medik8/oxy-r-peptides/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/au/p/medik8/oxy-r-peptides/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/au/p/medik8/oxy-r-peptides/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/au/p/medik8/oxy-r-peptides/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/au/p/medik8/oxy-r-peptides/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/au/p/medik8/oxy-r-peptides/for/mature-skin): Superior (this page)
- [Dry sensitive skin](https://lovi.care/skincare/au/p/medik8/oxy-r-peptides/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/medik8/oxy-r-peptides/for/oily-acne-prone-skin): High

## Key ingredients

Oxyresveratrol, Peptides, Sodium Hyaluronate, Lactic Acid, Glycerin

## What the research says

- Acetylated derivatives of resveratrol and oxyresveratrol inhibit UVB-induced MMP-1 expression and suppress ROS levels in human dermal fibroblasts via MAPK and Akt/mTOR signaling pathways. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439500/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- Application of a new brightening complex cream containing niacinamide, tranexamic acid, oxyresveratrol, glutathione disulfide, and linoleic acid for 12 weeks increased skin lightness (L*-value) and significantly decreased melanin index and erythema index in Korean women. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28512843/))
- Topical application of mulberroside A, oxyresveratrol, and oxyresveratrol-3-O-glucoside reduced UVB-induced skin pigmentation and melanogenic enzyme expression in brown guinea pigs compared to vehicle control, with oxyresveratrol showing the greatest effect. ([Food and Chemical Toxicology, 2011](https://pubmed.ncbi.nlm.nih.gov/21946069/))
- Topical oxyresveratrol microemulsion at 20-30% w/w effectively delayed skin lesion development and protected mice from death compared to untreated controls. ([AAPS PharmSciTech, 2012](https://pubmed.ncbi.nlm.nih.gov/22996670/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin. ([Cutis, 2004](https://pubmed.ncbi.nlm.nih.gov/15027519/))
- Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties. ([Journal of the American Academy of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1597538/))
- A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33178384/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, users with hyperpigmentation, melasma, and post-inflammatory erythema (PIE) frequently report visible skin brightening and the fading of dark spots, often noting a smoother texture and "glass-like" glow within weeks. While many experience rapid results, a minority of users report no visible changes or mild breakouts, and the short shelf life of the activated formula is a noted consideration.

- Liked: Fades dark spots (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Fast absorption (sometimes noted)
- Liked: Gentle formulation (sometimes noted)
- Liked: Rapid results (sometimes noted)
- Disliked: Ineffective for some (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Short shelf life (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Medik8 Oxy-R Peptides one of the best fits for mature skin?

Medik8 Oxy-R Peptides is one of the best fits for mature skin because it uses Hydroxyresveratrol and Tetrapeptide-30 to smooth out fine lines and wrinkles. It also contains glycerin and sodium hyaluronate to keep skin deeply hydrated and comfortable. Gluconolactone further helps by gently refining skin texture.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which ingredients make this serum a good fit for mature skin?

Hydroxyresveratrol and peptides make this serum a good fit for mature skin by supporting collagen and firmness to help smooth fine lines and wrinkles. Glycerin and sodium hyaluronate further help by keeping the skin hydrated and comfortable.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439500/)

### What does Oxyresveratrol do for mature skin?

Oxyresveratrol helps mature skin by increasing collagen expression and reducing advanced glycation end products, which supports firmer and smoother skin. It may also help improve the look of age spots by reducing melanin production and skin pigmentation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35615726/), [Food and Chemical Toxicology, 2011](https://pubmed.ncbi.nlm.nih.gov/21946069/)

### What do Peptides do for mature skin?

Peptides help mature skin by signaling skin cells to boost collagen production, which improves firmness and smooths out fine lines. They are generally safe to use daily, though their ability to deliver results depends heavily on how well the formula can sink into the skin.
Sources: [International Journal of Cosmetic Science, 2009](https://pubmed.ncbi.nlm.nih.gov/19570099/), [Biomolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/39858482/)

### Where does it go in a skincare routine for mature skin?

Medik8 Oxy-R Peptides goes in the evening routine after cleansing and before moisturizing. Putting this treatment in the evening helps keep it simple and adds extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying it before your retinol at night, or by alternating nights to keep your skin calm. Glycerin and sodium hyaluronate help keep your skin feeling comfortable while minimizing potential dryness.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use it?

Apply this treatment in the evening as part of your routine. It is very safe and unlikely to cause irritation, so you can use it regularly to help smooth fine lines and keep your skin feeling soft.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can it clog pores, cause breakouts or purging for mature skin?

Medik8 Oxy-R Peptides is unlikely to cause breakouts or clog pores on mature skin, as it has a very low risk of this issue according to user feedback and features soothing components. The formula is designed to hydrate and smooth the skin comfortably without using harsh ingredients that typically trigger irritation or clogged pores.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/au/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — A$50.60 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/au/p/la-mer/the-regenerating-serum/for/mature-skin) — High fit — A$740.13 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/au/p/augustinus-bader/the-serum/for/mature-skin) — High fit — A$639.95 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/au/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — A$73.61 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/au/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — A$37.00 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/au/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — A$116.08 at Amazon

## Where to buy

No store in Australia has a checked price for this product, so the page shows none.

## Ingredients

Water, Butylene Glycol, Artocarpus Lakoocha Extract Wood, Hydroxyresveratrol, Gluconolactone, Acetyl Glycyl Beta-Alanine, Glycerin, Lactic Acid, Sodium Hyaluronate, Sodium Benzoate, Disodium Edta, Tetrapeptide-30, Xanthan Gum, Sodium Metabisulfite, Calcium Gluconate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medik8/oxy-r-peptides/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medik8/oxy-r-peptides/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/medik8/oxy-r-peptides/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/medik8/oxy-r-peptides/for/mature-skin
- France: https://lovi.care/skincare/fr/p/medik8/oxy-r-peptides/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/medik8/oxy-r-peptides/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/medik8/oxy-r-peptides/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/medik8/oxy-r-peptides/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/medik8/oxy-r-peptides/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/medik8/oxy-r-peptides/for/mature-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/medik8/oxy-r-peptides/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medik8/oxy-r-peptides/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medik8/oxy-r-peptides/for/mature-skin