Mediheal N.M.F Water Drop Daily Sun Serum for skin with dark spots

How to apply

Questions and answers

What the research says

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• Topical formulations containing ascorbyl tetraisopalmitate, coenzyme Q10, green tea polyphenols, and resveratrol reduced the release of inflammatory cytokines and attenuated inflammatory signs compared to untreated skin and vehicle in 25 Japanese volunteers exposed to sodium dodecyl sulfate.

  European Journal of Pharmaceutics and Biopharmaceutics, 2017

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Maximal topical applications of 6% bemotrizinol in a model sunscreen formulation did not result in meaningful systemic exposure in humans.

  Regulatory Toxicology and Pharmacology, 2023

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

Ingredients

Water, Glycerin, Butylene Glycol, C12-15 Alkyl Benzoate, 1,2-Hexanediol, Diethylamino Hydroxybenzoyl Hexyl Benzoate, Niacinamide, Polymethyl Methacrylate, Behenyl Alcohol, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Hydrolyzed Collagen, Sodium Hyaluronate Crosspolymer, Potassium Hyaluronate, Sodium Acetylated Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Ceramide Np, Fructan, Potassium Cetyl Phosphate, Ascorbyl Tetraisopalmitate, Tocopherol, Polyisobutene, Ethylhexylglycerin, Dna, Ammonium Acryloyldimethyltaurate Beheneth-25 Methacrylate Crosspolymer, Xylitylglucoside, Anhydroxylitol, Xylitol, Caprylyl Capryl Glucoside, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Sorbitan Oleate, Glucose, Hydrogenated Lecithin, Pentylene Glycol, Caprylic Capric Triglyceride, Carbomer, Adenosine, Disodium Edta

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.