# Medicube Triple Collagen Serum for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/au/p/medicube/triple-collagen-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [Medicube](https://lovi.care/skincare/au/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/au/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your combination skin, this serum leverages niacinamide to help regulate oil production and multiple forms of collagen and hyaluronic acid to provide excellent plumping and firming effects.
- While the hydration and barrier repair actions are beneficial, the primary ingredients do not directly target your concerns of acne, blemishes, and breakouts.
- The formula is safe for your skin, containing soothing ingredients like glycerin and avoiding harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/medicube/triple-collagen-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/au/p/medicube/triple-collagen-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/au/p/medicube/triple-collagen-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/au/p/medicube/triple-collagen-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/au/p/medicube/triple-collagen-serum/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/au/p/medicube/triple-collagen-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/au/p/medicube/triple-collagen-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/au/p/medicube/triple-collagen-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/medicube/triple-collagen-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Triple Collagen Complex, Sodium Hyaluronate, Niacinamide, Collagen Extract, Adenosine

## What the research says

- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))

## What reviewers say

Users frequently report this serum provides deep hydration, leading to a plumped, radiant complexion often described as 'glass skin'. It is well-loved for its smooth, non-greasy texture and effectiveness in diminishing fine lines, making it a great base for makeup. Some users find the fragrance to be strong and occasionally encounter issues with the packaging.

- Liked: Deep hydration (mostly mentioned)
- Liked: Glow and radiance (often mentioned)
- Liked: Good texture (sometimes noted)
- Liked: Plumping and anti-aging (sometimes noted)
- Disliked: Packaging issues (sometimes noted)
- Disliked: Strong fragrance (sometimes noted)
- Liked: Makeup compatibility (rarely noted)
- Disliked: Skin sensitivity (rarely noted)
- Disliked: Slightly sticky (rarely noted)
- Disliked: Small quantity (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Medicube Triple Collagen Serum a great fit for acne-prone skin?

This serum is a great fit because it uses niacinamide to help control oil production while delivering soothing and hydrating ingredients like glycerin and hyaluronic acid. It is very safe for your skin, though it does not directly target breakouts or blemishes.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for acne-prone skin?

This serum is a good fit because it includes niacinamide to help control oil, alongside glycerin to soothe your skin. While it is safe and provides nice hydration, it lacks ingredients that directly target breakouts.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Triple Collagen do for acne-prone skin?

Triple Collagen helps keep acne-prone skin calm and clear by supporting overall skin health. This type of product works best when it also includes ingredients that soothe angry spots and balance oily areas without clogging pores.

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Where does this serum go in a skincare routine for acne-prone skin?

This treatment serum goes in the evening routine after cleansing and before moisturizing, which keeps it simple and safe. Niacinamide helps regulate oil production, while collagen and hyaluronic acid provide plumping effects.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use it with retinol, and in what order?

You can use this treatment with retinol by applying the retinol first, letting it dry, and then following with this serum. This order helps keep your skin calm and hydrated while minimizing any potential irritation from the retinol.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

You can use this serum in your evening routine. It is a great fit for your skin, featuring niacinamide to help balance oil and hyaluronic acid for hydration.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can it clog pores, cause breakouts or purging for acne-prone skin?

Medicube Triple Collagen Serum is unlikely to clog pores or cause breakouts on acne-prone skin because it avoids harsh substances and includes soothing ingredients like glycerin. While it does not directly target breakouts, niacinamide helps regulate oil production to keep skin balanced.

### Is it fragrance-free and alcohol-free?

It contains fragrance (linalool and limonene) and drying alcohol (alcohol denat).

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/au/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — A$16.95 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/au/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — A$52.32 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/au/p/neogen-dermalogy/real-vitamin-c-serum/for/acne-prone-skin) — Superior fit — A$50.60 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/au/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — A$13.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/au/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — A$34.66 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/au/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — A$24.00 at Amazon

## Where to buy

- Amazon.com.au: A$30.20 (https://www.amazon.com.au/dp/B0DNQ3RTC1?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Glycerin, Butylene Glycol, Cetyl Ethylhexanoate, Niacinamide, Glycereth-26, Alcohol Denat, 1,2-Hexanediol, Trehalose, Carbomer, Cetearyl Olivate, Tromethamine, Sorbitan Olivate, Ethylhexylglycerin, Collagen Extract, Adenosine, Disodium Edta, Atelocollagen, Desamido Collagen, Hydrolyzed Collagen, Sodium Hyaluronate, Water-Soluble Collagen, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Collagen, Collagen Amino Acids, Sodium Acetylated Hyaluronate, Procollagen, Cyclopentasiloxane, Hydroxypropyltrimonium Hyaluronate, Cyclohexasiloxane, Dimethicone, Benzyl Benzoate, Linalool, Limonene
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/triple-collagen-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/triple-collagen-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/triple-collagen-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/medicube/triple-collagen-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/medicube/triple-collagen-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/medicube/triple-collagen-serum/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/triple-collagen-serum/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/medicube/triple-collagen-serum/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/triple-collagen-serum/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/medicube/triple-collagen-serum/for/acne-prone-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/medicube/triple-collagen-serum/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/triple-collagen-serum/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/triple-collagen-serum/for/acne-prone-skin