# Medi-Peel Peptide 9 Volume Tox Cream for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/au/p/medi-peel/peptide-9-volume-tox-cream/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [Medi-Peel](https://lovi.care/skincare/au/brands/medi-peel)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/au/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other moisturizers fit it better.

## Why this fit

- Offers moderate moisturizing and anti-aging treatment for your combination skin, as sodium hyaluronate and adenosine hydrate and smooth fine lines, but it does not specifically target your oily shine concern.
- Glycerin and trehalose provide hydration suitable for combination skin, though the formula lacks strong seboregulation ingredients often needed for oily shine.
- The product is safe for your combination skin with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/medi-peel/peptide-9-volume-tox-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/au/p/medi-peel/peptide-9-volume-tox-cream/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/au/p/medi-peel/peptide-9-volume-tox-cream/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/au/p/medi-peel/peptide-9-volume-tox-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/au/p/medi-peel/peptide-9-volume-tox-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/au/p/medi-peel/peptide-9-volume-tox-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/au/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/au/p/medi-peel/peptide-9-volume-tox-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/medi-peel/peptide-9-volume-tox-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Peptide 9, Sodium Hyaluronate, Copper Tripeptide-1, Hydrolyzed Collagen, Adenosine

## What the research says

- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Sodium trehalose sulfate decreased transepidermal water loss and increased stratum corneum water content in participants with low stratum corneum water content when applied for 4 weeks compared to placebo. ([Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38606717/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- Adenosine treatment of dermal papilla cells upregulates fibroblast growth factor-7 expression via the A2b adenosine receptor and intracellular cAMP signaling, and fibroblast growth factor-7 significantly stimulates hair fiber elongation in human scalp hair follicle organ cultures. ([The Journal of Investigative Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17301835/))

## What reviewers say

Based on limited data, users highly praise this cream for its ability to deeply hydrate and plump the skin, resulting in a softer, bouncier, and glowing complexion, making it a favorite for aging and dry skin types. Its lightweight texture absorbs quickly without residue. While many appreciate its anti-aging benefits and pleasant scent, some users with acne-prone skin report breakouts, and a few find the moisture insufficient for very dry winter conditions.

- Liked: Hydrates and plumps (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Anti-aging effects (sometimes noted)
- Liked: Pleasant scent (sometimes noted)
- Disliked: Causes breakouts (sometimes noted)
- Disliked: Expensive for amount (rarely noted)
- Disliked: Not enough moisture (rarely noted)
- Disliked: Texture issues (rarely noted)

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Medi-Peel Peptide 9 Volume Tox Cream work for combination skin?

This cream works moderately well for combination skin by hydrating and smoothing fine lines with sodium hyaluronate and adenosine, but it does not specifically target oily shine. To better fit combination skin, a product of this type needs targeted oil-balancing ingredients along with effective moisturizers to manage shine while keeping skin hydrated.
Sources: [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/), [International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/)

### Which ingredients make this cream a good fit for combination skin?

Sodium hyaluronate and adenosine help hydrate and smooth fine lines on combination skin. However, since this cream is an average fit, a product of this type needs effective brightening ingredients that reduce oily shine.
Sources: [International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Peptide 9 do for combination skin?

Peptides help smooth wrinkles and keep combination skin hydrated and firm. This type of ingredient works best when it is paired with lightweight moisturizers or balancing hydrators that keep dry areas soft without making oily zones greasy.
Sources: [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35064615/), [Sheng Wu Yi Xue Gong Cheng Xue Za Zhi = Journal of Biomedical Engineering = Shengwu Yixue Gongchengxue Zazhi, 2022](https://pubmed.ncbi.nlm.nih.gov/36575096/)

### What does Hyaluronic Acid do for combination skin?

Hyaluronic acid is a great fit for combination skin because it quenches dry areas with a boost of hydration while keeping oily zones balanced. Regular use helps smooth out fine lines and makes your skin feel soft and plump without causing irritation.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### Where does this cream go in a skincare routine for combination skin?

This moisturizing treatment goes in the morning and evening routine after your toner and before your sunscreen or makeup. It is safe for your skin with no risks of irritation. Combination skin needs a product of this type that also includes ingredients to control oily shine.

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol, and it works best when you apply it after your retinol treatment in your evening routine. Using a moisturizer like this helps reduce dryness and irritation while supporting your skin barrier during retinol use. Combination skin of this type needs a formula that balances hydration while managing oily shine.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

Use this moisturizing treatment twice daily as part of your routine. Daily application helps improve skin moisture, smoothness, and overall texture while keeping the skin safe from irritation. To properly care for combination skin, this type of product also needs ingredients that manage oily shine.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for combination skin?

This cream may cause breakouts for combination skin, as some reviewers report this issue. Combination skin of this type needs formulas with strong oil-control ingredients to help prevent clogged pores.

### Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment around the eyes and on the body because it has a safe profile with no harsh ingredients. The eyelid is among the thinnest areas of the skin, making gentle hydration particularly helpful there.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for combination skin

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/au/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/combination-skin) — Superior fit — A$24.00 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/au/p/the-ordinary/natural-moisturizing-factors-ha/for/combination-skin) — High fit — A$19.90 at Amazon
- [Anua Heartleaf 78% Soothing Cream](https://lovi.care/skincare/au/p/anua/heartleaf-78-soothing-cream/for/combination-skin) — High fit — A$42.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/au/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — A$73.61 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/au/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — A$42.00 at Amazon
- Pre-Cleanser: [Pyunkang Yul Deep Cleansing Oil](https://lovi.care/skincare/au/p/pyunkang-yul/deep-cleansing-oil/for/combination-skin) — Superior fit — A$30.99 at Amazon

## Where to buy

- Amazon.com.au: A$51.37 (https://www.amazon.com.au/dp/B08LMLC16K?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Methylpropanediol, Glycerin, Dimethicone, Cyclopentasiloxane, 1,2-Hexanediol, Caprylic Capric Triglyceride, Cetearyl Alcohol, Cetearyl Olivate, Cyclohexasiloxane, Sorbitan Olivate, Glyceryl Stearate, Pentaerythrityl Tetraisostearate, Peg-100 Stearate, Cetearyl Glucoside, Carbomer, Arginine, Sodium Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Isohexadecane, Trehalose, Helianthus Annuus Seed Oil Sunflower Seed Oil, Xanthan Gum, Adenosine, Polysorbate 80, Sodium Hyaluronate, Disodium Edta, Sorbitan Oleate, Glycine Soja Oil Soybean Oil, Desamido Collagen, Juniperus Communis Fruit Extract, Magnolia Officinalis Bark Extract, Eucalyptus Globulus Leaf Extract, Fructan, Hydrolyzed Collagen, Butylene Glycol, Hydrogenated Polyisobutene, Bixa Orellana Seed Oil, Propanediol, Sodium Hyaluronate Crosspolymer, Sorbitan Laurate, Propylene Glycol, Hydrolyzed Glycosaminoglycans, Nonoxynol-12, Phenoxyethanol, Chondrus Crispus Extract, Tocopherol, Hydroxyethylcellulose, Benzyl Glycol, Acetyl Dipeptide-1 Cetyl Ester, Astaxanthin, Ethyl Hexanediol, Hydrolyzed Elastin, Hydrolyzed Hyaluronic Acid, Caprylyl Glycol, Palmitoyl Tripeptide-5, Palmitoyl Pentapeptide-4, Acetyl Hexapeptide-8, Copper Tripeptide-1, Hexapeptide-9, Palmitoyl Tetrapeptide-7, Acetyl Octapeptide-3, Raspberry Ketone, Palmitoyl Tripeptide-1, Palmitoyl Oligopeptide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medi-peel/peptide-9-volume-tox-cream/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medi-peel/peptide-9-volume-tox-cream/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/medi-peel/peptide-9-volume-tox-cream/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/medi-peel/peptide-9-volume-tox-cream/for/combination-skin
- France: https://lovi.care/skincare/fr/p/medi-peel/peptide-9-volume-tox-cream/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/medi-peel/peptide-9-volume-tox-cream/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/medi-peel/peptide-9-volume-tox-cream/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/medi-peel/peptide-9-volume-tox-cream/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/medi-peel/peptide-9-volume-tox-cream/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/medi-peel/peptide-9-volume-tox-cream/for/combination-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/medi-peel/peptide-9-volume-tox-cream/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medi-peel/peptide-9-volume-tox-cream/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medi-peel/peptide-9-volume-tox-cream/for/combination-skin