# Lancôme Génifique Ultimate for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/au/p/lancome/genifique-ultimate/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [Lancôme](https://lovi.care/skincare/au/brands/lancome)
Category: [Serums and treatments](https://lovi.care/skincare/au/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your combination skin, as bifida ferment lysate and hyaluronic acid enhance barrier resilience and hydration, but it lacks targeted ingredients for your primary concern of oily shine.
- The formula is safe for your combination skin, with no harsh ingredients that would cause irritation.
- While it provides general skincare benefits, the formulation does not specifically address oil control for your oily shine concern.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/lancome/genifique-ultimate/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/au/p/lancome/genifique-ultimate/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/au/p/lancome/genifique-ultimate/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/au/p/lancome/genifique-ultimate/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/au/p/lancome/genifique-ultimate/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/au/p/lancome/genifique-ultimate/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/au/p/lancome/genifique-ultimate/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/au/p/lancome/genifique-ultimate/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/lancome/genifique-ultimate/for/oily-acne-prone-skin): Average

## Key ingredients

Bifida Lysate Ferment, Hyaluronic Acid, Glycerin, Tocopheryl Acetate, Adenosine

## What the research says

- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG. ([Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))

## Why other serums fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## What reviewers say

Based on a very large amount of data, users love this serum's lightweight, silky texture that absorbs quickly, leaving skin feeling soothed, hydrated, and plump without any stickiness. While many experience smoother skin and a strengthened barrier, some note that anti-aging effects like wrinkle reduction are subtle and require consistent, long-term use. The high price point is frequently mentioned as a drawback.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Hydration and plumping (often mentioned)
- Liked: Soothing and calming (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Improves skin texture (sometimes noted)
- Liked: Makeup compatibility (sometimes noted)
- Disliked: Subtle results (sometimes noted)
- Disliked: Dropper design (rarely noted)
- Disliked: Pilling issues (rarely noted)
- Disliked: Unpleasant scent (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Lancôme Génifique Ultimate Serum work for combination skin?

Lancome Genifique Ultimate Serum works moderately well for combination skin by boosting hydration and strengthening the skin barrier, though it lacks targeted ingredients for oily shine. A product of this type needs ingredients like niacinamide, zinc PCA, or propolis to regulate oiliness and balance combination skin.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### Which ingredients make this serum a good fit for combination skin?

Bifida ferment lysate and hyaluronic acid make this serum a fit by strengthening your skin barrier and boosting hydration. However, because it lacks oil-controlling ingredients for oily shine, a treatment for combination skin needs to include ingredients like niacinamide, zinc PCA, and propolis to regulate oiliness.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does Bifida Ferment Lysate do for combination skin?

Bifida Ferment Lysate helps strengthen the skin barrier and calm irritation, making it a good fit for combination skin that is prone to sensitivity. This ingredient works by supporting the skin defenses, keeping moisture locked in, and helping to reduce redness.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/)

### What does Hyaluronic Acid do for combination skin?

Hyaluronic acid is a great fit for combination skin because it quenches dry areas with a boost of hydration while keeping oily zones balanced. Regular use helps smooth out fine lines and makes your skin feel soft and plump without causing irritation.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### Where does this serum go in a skincare routine for combination skin?

This treatment serum goes in the evening routine after cleansing and before moisturizing, as putting it then keeps your routine simple and avoids sun exposure concerns. A product of this type needs balancing ingredients like niacinamide or clay to help control oily shine and improve your combination skin.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the treatment first and following with your retinol. The formula is safe for combination skin and is unlikely to cause irritation.

### How often should I use this serum?

This treatment works well in the evening for your combination skin to keep it hydrated and calm. To properly care for combination skin, a product of this type needs added oil-control ingredients to help manage oily shine.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36798538/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

Lancôme Génifique Ultimate is unlikely to clog pores or cause breakouts for combination skin because its formula has no harsh ingredients that cause irritation. However, since it does not target oily shine, combination skin prone to breakouts still needs lightweight, oil-controlling ingredients like salicylic acid or niacinamide to help keep pores clear.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (parfum) and drying alcohol (alcohol denat).

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/au/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — A$16.95 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/au/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — A$52.32 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/au/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — A$639.95 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/au/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — A$73.61 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/au/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — A$42.00 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/au/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — A$22.99 at Amazon

## Where to buy

- Amazon.com.au: A$429.00 (https://www.amazon.com.au/dp/B0DRT1K98M?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)
Prices checked 2 Nov 2026.

## Ingredients

Water, Bifida Lysate Ferment, Glycerin, Dimethicone, Alcohol Denat, Hydroxyethylpiperazine Ethane Sulfonic Acid, Hyaluronic Acid, Tocopheryl Acetate, Adenosine, Phenoxyethanol, Ammonium Polyacryloyldimethyl Taurate, Sodium Hydroxide, Caprylyl Glycol, Disodium Edta, Citric Acid, Xanthan Gum, Polysorbate 20, Parfum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/lancome/genifique-ultimate/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/lancome/genifique-ultimate/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/lancome/genifique-ultimate/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/lancome/genifique-ultimate/for/combination-skin
- France: https://lovi.care/skincare/fr/p/lancome/genifique-ultimate/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/lancome/genifique-ultimate/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/lancome/genifique-ultimate/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/lancome/genifique-ultimate/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/lancome/genifique-ultimate/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/lancome/genifique-ultimate/for/combination-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/lancome/genifique-ultimate/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/lancome/genifique-ultimate/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/lancome/genifique-ultimate/for/combination-skin