# iS Clinical Super Serum Advance+ for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/au/p/is-clinical/super-serum-advance/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [iS Clinical](https://lovi.care/skincare/au/brands/is-clinical)
Category: [Serums and treatments](https://lovi.care/skincare/au/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for sensitive skin.

## Why this fit

- Highly suitable for your normal skin, this serum features Ascorbic Acid and Sodium Hyaluronate to provide antioxidant activity and humectant action, respectively, while Arbutin and Ascorbic Acid work to brighten and even your skin tone.
- While it offers general hydration and antioxidant protection, it lacks specialized ingredients to effectively address your specific concerns of redness and irritation.
- The formulation is safe for your sensitive skin, containing soothing ingredients like Asiaticoside, Asiatic Acid, and Madecassic Acid, and is free from harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/is-clinical/super-serum-advance/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/au/p/is-clinical/super-serum-advance/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/au/p/is-clinical/super-serum-advance/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/au/p/is-clinical/super-serum-advance/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/au/p/is-clinical/super-serum-advance/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/au/p/is-clinical/super-serum-advance/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/au/p/is-clinical/super-serum-advance/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/au/p/is-clinical/super-serum-advance/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/is-clinical/super-serum-advance/for/oily-acne-prone-skin): High

## Key ingredients

Ascorbic Acid, Sodium Hyaluronate, Arbutin, Tripeptide-1, Madecassic Acid

## What the research says

- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability. ([Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/))
- Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations. ([Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/))
- Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39918262/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))

## What reviewers say

This serum is highly regarded for its ability to brighten skin and reduce the appearance of scars and stretch marks. It is often described as a lightweight, fast-absorbing treatment suitable for acne-prone and aging skin, although its high price is a frequent concern among users.

- Liked: Brightens skin tone (mostly mentioned)
- Liked: Anti-aging effects (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Reduces scars/marks (often mentioned)
- Disliked: High price (often mentioned)
- Liked: Non-irritating (sometimes noted)
- Disliked: Watery consistency (sometimes noted)
- Disliked: Application sensation (rarely noted)
- Disliked: Lack of results (rarely noted)
- Disliked: Packaging/Value (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Super Serum Advance+ a great fit for sensitive skin?

iS Clinical Super Serum Advance+ is a great fit because it contains soothing ingredients like Asiaticoside, Asiatic Acid, and Madecassic Acid that help keep sensitive skin calm and safe from harsh reactions. It also provides extra antioxidant protection and hydration while helping to brighten and even out your skin tone.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### Which ingredients make this serum a good fit for sensitive skin?

This serum is a good fit for sensitive skin because it contains soothing ingredients like Asiaticoside, Asiatic Acid, and Madecassic Acid. These components help calm the skin and support a safe, gentle experience.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Vitamin C do for sensitive skin?

Vitamin C helps brighten skin, smooth out fine lines, and fade dark spots. Clinical studies show it is generally safe and well-tolerated when improving overall skin quality.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/)

### What does Hyaluronic Acid do for sensitive skin?

Hyaluronic acid helps calm and hydrate sensitive skin while supporting the skin barrier to keep it soft and comfortable. Clinical studies show it improves surface moisture and reduces dryness, roughness, and redness without irritation.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41037531/), [Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29356277/)

### Where does this serum go in a skincare routine for sensitive skin?

This treatment goes in the evening routine for sensitive skin, applied after the soothing toner and before the moisturizer. Putting this serum in the evening helps keep things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum in the morning and your retinol at night to keep your skin calm and avoid irritation. Applying them at different times of day helps protect sensitive skin while still giving you brightening and anti-aging benefits.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

You can use this serum in your evening routine for simplicity and extra safety around sun exposure. It helps keep your skin calm and hydrated while being safe for sensitive skin.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to clog pores or cause breakouts for sensitive skin because its watery texture absorbs easily without heavy oils. It also contains soothing ingredients that help keep skin calm.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/au/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — A$50.60 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/au/p/cosrx/the-vitamin-c-23-serum/for/sensitive-skin) — High fit — A$27.50 at Amazon
- [Skin1004 Probio-Cica Intensive Ampoule](https://lovi.care/skincare/au/p/skin1004/probio-cica-intensive-ampoule/for/sensitive-skin) — High fit — A$34.41 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/au/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — A$73.61 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/au/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — A$54.00 at Amazon
- Moisturizer with Sun Protection: [Bioderma Bioderma Photoderm Mineral SPF 50+](https://lovi.care/skincare/au/p/bioderma/photoderm-mineral-fluide-spf50/for/sensitive-skin) — Superior fit — A$24.49 at Amazon

## Where to buy

- Amazon.com.au: A$178.51 (https://www.amazon.com.au/dp/B009QZEHAO?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)
Prices checked 2 Nov 2026.

## Ingredients

Water, Ascorbic Acid, Sodium Hyaluronate, Pentylene Glycol, Arbutin, Polyporus Umbellatus Extract Mushroom Extract, Calcium Pantothenate, Zinc Sulfate, Urea, Glucose, Guanidine Hcl, Tripeptide-1, Glycerin, Phenoxyethanol, Asiaticoside, Asiatic Acid, Madecassic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/is-clinical/super-serum-advance/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/is-clinical/super-serum-advance/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/is-clinical/super-serum-advance/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/is-clinical/super-serum-advance/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/is-clinical/super-serum-advance/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/is-clinical/super-serum-advance/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/is-clinical/super-serum-advance/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/is-clinical/super-serum-advance/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/is-clinical/super-serum-advance/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/is-clinical/super-serum-advance/for/sensitive-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/is-clinical/super-serum-advance/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/is-clinical/super-serum-advance/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/is-clinical/super-serum-advance/for/sensitive-skin