# IOPE Pro Peeling Enzyme Wash for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/au/p/iope/pro-peeling-enzyme-wash/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [IOPE](https://lovi.care/skincare/au/brands/iope)
Category: [Exfoliants](https://lovi.care/skincare/au/best/exfoliators)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few products fit it even better.

## Why this fit

- Offers moderate exfoliation for your redness and irritation, as papain and protease provide enzymatic cleansing suitable for your normal skin with sensitivity.
- Betaine and squalane further support humectant and emollient actions, enhancing overall skin comfort and hydration.
- The product is safe for your skin due to the absence of harsh ingredients, minimizing the risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/iope/pro-peeling-enzyme-wash/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/au/p/iope/pro-peeling-enzyme-wash/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/au/p/iope/pro-peeling-enzyme-wash/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/au/p/iope/pro-peeling-enzyme-wash/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/au/p/iope/pro-peeling-enzyme-wash/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/au/p/iope/pro-peeling-enzyme-wash/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/au/p/iope/pro-peeling-enzyme-wash/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/au/p/iope/pro-peeling-enzyme-wash/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/iope/pro-peeling-enzyme-wash/for/oily-acne-prone-skin): High

## Key ingredients

Papain, Squalane, Acetyl Glucosamine, Betaine, Vaccinium Myrtillus Fruit Extract

## What the research says

- Topical papain treatment may slightly decrease pain within 30 minutes in humans stung by Chrysaora chinensis compared to placebo. ([Wilderness & Environmental Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/26827260/))
- A fixed combination of hydroxypinacolone retinoate, retinol glycospheres, and papain glycospheres in aqueous gel applied once daily for 12 weeks achieved a 41% mean reduction in GAGS score and a 40.8% mean reduction in total lesions, with 15.3% of patients experiencing mild to moderate local side effects, in 94 evaluable patients with comedonal-papular, mild to moderate acne of the face. ([Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/))
- Reflux extraction of Carica papaya leaves yielded higher antioxidant capacity and superior in vitro wound-healing activities including fibroblast proliferation, cell migration, and collagen synthesis in human skin fibroblasts compared to ultrasonic-assisted extraction and agitation. ([Molecules, 2020](https://pubmed.ncbi.nlm.nih.gov/31991676/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- Topical dry mouth products containing olive oil, betaine, and xylitol significantly increased unstimulated whole salivary flow rates, reduced xerostomia complaints, and improved quality of life in adults with polypharmacy-induced xerostomia compared to their normal routine care, with no clinically significant adverse events. ([Journal of Oral Rehabilitation, 2007](https://pubmed.ncbi.nlm.nih.gov/17824884/))
- Soaps containing betaine caused the least skin irritation compared to other tested soaps in twenty-eight healthy subjects, though irritation did not decrease with increasing concentrations of betaine. ([Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/))
- A combination of Aloe barbadensis leaf extract and trimethylglycine in a 1:1 mass ratio synergistically increased aquaporin 3 expression by up to 380% in keratinocytes and safely improved skin hydration in healthy volunteers. ([Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611819/))
- Fermented bilberry extract improved wrinkle depth, skin smoothness, roughness, firmness, elasticity, antioxidant capacity, and complexion evenness compared to a placebo in 66 subjects over 84 days. ([Nutrients, 2024](https://pubmed.ncbi.nlm.nih.gov/39064646/))
- Topical application of oil-in-water creams containing wild bilberry leaves extract and seeds oil produced significant beneficial effects on the skin of healthy human volunteers. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/33809607/))
- Bilberry fruit extract incorporated into chitosan-based hydrogels demonstrated antioxidant, anti-hyaluronidase, and anti-tyrosinase activities, supporting their potential use in topical anti-aging preparations. ([Antioxidants, 2024](https://pubmed.ncbi.nlm.nih.gov/38247529/))

## What reviewers say

Based on limited data, users find this enzyme wash effectively exfoliates and smooths skin, leaving it feeling soft and clean without dryness, making it suitable for sensitive skin. However, the product is considered expensive for the quantity provided, and the powder format can lead to clumping and dispensing difficulties.

- Liked: Improved skin texture (mostly mentioned)
- Liked: Gentle exfoliation (often mentioned)
- Liked: Non-stripping cleanse (often mentioned)
- Disliked: Expensive for amount (often mentioned)
- Disliked: Packaging issues (often mentioned)
- Liked: Effective deep clean (sometimes noted)
- Disliked: Availability issues (sometimes noted)
- Disliked: Potential irritation (rarely noted)

## How to apply

- Could be used as part of your PM routine once a week. Start slowly and increase usage only if your skin feels comfortable.
- Apply this enzyme powder cleanser after your regular cleanser, and before your hydrating toner and moisturizer.
- Pour a small amount into wet hands, lather into a foam, and gently massage onto your face without harsh rubbing.
- For sensitive skin, apply this product on slightly damp skin to ensure better tolerance and comfort.
- Avoid the eye area and do a patch test before your very first use to prevent irritation.
- Video: https://storage.pora.ai/2d8db6e67371d665a6a7736b5ed5d762.mp4

## Questions and answers

### What makes IOPE Pro Peeling Enzyme Wash a great fit for sensitive skin?

IOPE Pro Peeling Enzyme Wash is a great fit because its papain and protease provide gentle enzymatic cleansing that helps avoid redness and irritation. Betaine and squalane further support comfort and hydration, while the absence of harsh ingredients keeps your skin safe.
Sources: [Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611819/), [Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/)

### Which ingredients make this cleanser a good fit for sensitive skin?

Papain and protease provide gentle enzymatic cleansing that helps keep redness and irritation at bay. Additionally, betaine and squalane boost skin comfort and hydration so your face feels soft and calm.
Sources: [Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611819/), [Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/)

### What does Papain do for sensitive skin?

Papain is not a good fit for sensitive skin because it can disrupt the skin barrier, cause inflammation, and act as a strong allergen. Sensitive skin needs gentle, soothing, and repairing ingredients that protect the outer layer rather than break it down.
Sources: [The Journal of Investigative Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25705851/)

### What does Squalane do for sensitive skin?

Squalane helps calm sensitive skin by defending against everyday irritation and keeping it smooth and soft. It is unlikely to cause irritation and supports your skin barrier so it stays comfortable and hydrated.
Sources: [International Journal of Molecular Sciences, 2017](https://pubmed.ncbi.nlm.nih.gov/29280987/)

### Where does this cleanser go in a skincare routine for sensitive skin?

This enzyme powder is a great fit for your sensitive skin because papain and protease offer gentle exfoliation while betaine and squalane keep your face calm and hydrated. In your weekly routine, it goes after your cleanser and before a nourishing mask. It is safe to use once a week to minimize the risk of redness.

### Can I use this cleanser with retinol, and in what order?

You can use this cleanser in your weekly routine, but it is best to avoid using it on the same nights as your retinol to prevent irritation. Using this gentle enzyme powder separately from your strong treatments helps keep your skin calm and comfortable.

### How often should I use this cleanser?

Start by using this enzyme powder cleanser just once a week, and if your skin feels comfortable and tolerates it well, you can carefully use it more often. The gentle enzymes offer moderate exfoliation, while ingredients like squalane and betaine help keep your skin feeling calm and hydrated.

### Can this cleanser clog pores, cause breakouts or purging for sensitive skin?

This enzyme powder cleanser is unlikely to clog pores or cause breakouts on sensitive skin because it is free of heavy, pore-clogging oils. While chemical exfoliants can sometimes cause skin purging, the gentle plant enzymes here provide light cleansing that is very well tolerated by easily irritated skin.
Sources: [Skin Research and Technology, 2003](https://pubmed.ncbi.nlm.nih.gov/12535284/)

### Is this cleanser fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (ethanol).

## Alternatives for sensitive skin

- [Dr. Barbara Sturm Enzyme Cleanser](https://lovi.care/skincare/au/p/dr-barbara-sturm/enzyme-cleanser/for/sensitive-skin) — High fit — A$114.68 at Amazon
- [By Wishtrend Green Tea & Enzyme Powder Wash](https://lovi.care/skincare/au/p/by-wishtrend/green-tea-and-enzyme-powder-wash/for/sensitive-skin) — High fit — A$38.38 at Amazon
- [Fancl Deep Clear Washing Powder](https://lovi.care/skincare/au/p/fancl/deep-clear-washing-powder/for/sensitive-skin) — High fit — A$30.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/au/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — A$73.61 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/au/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — A$54.00 at Amazon
- Moisturizer with Sun Protection: [Bioderma Bioderma Photoderm Mineral SPF 50+](https://lovi.care/skincare/au/p/bioderma/photoderm-mineral-fluide-spf50/for/sensitive-skin) — Superior fit — A$24.49 at Amazon

## Where to buy

No store in Australia has a checked price for this product, so the page shows none.

## Ingredients

Microcrystalline Cellulose, Sodium Cocoyl Glycinate, Sodium Lauroyl Glutamate, Silica, Papain, Protease, Lipase, Lemon Fruit Extract, Saccharum Officinarum Extract, Sugar Maple Extract, Vaccinium Myrtillus Fruit Extract, Citrus Aurantium Dulcis Fruit Extract, Betaine, Squalane, Acetyl Glucosamine, Allantoin, Chitosan, Alpha-Glucan Oligosaccharide, Ethyl Cellulose, Ethanol, Xanthan Gum, Water, Butylene Glycol, Polycaprolactone, Peg-75, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/iope/pro-peeling-enzyme-wash/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/iope/pro-peeling-enzyme-wash/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/iope/pro-peeling-enzyme-wash/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/iope/pro-peeling-enzyme-wash/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/iope/pro-peeling-enzyme-wash/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/iope/pro-peeling-enzyme-wash/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/iope/pro-peeling-enzyme-wash/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/iope/pro-peeling-enzyme-wash/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/iope/pro-peeling-enzyme-wash/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/iope/pro-peeling-enzyme-wash/for/sensitive-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/iope/pro-peeling-enzyme-wash/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/iope/pro-peeling-enzyme-wash/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/iope/pro-peeling-enzyme-wash/for/sensitive-skin