# Eighth Day Regenerative Serum for skin with dark spots

**Lovi Fit: Average fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/au/p/eighth-day/regenerative-serum/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [Eighth Day](https://lovi.care/skincare/au/brands/eighth-day)
Category: [Serums and treatments](https://lovi.care/skincare/au/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for skin with dark spots; other serums fit it better.

## Why this fit

- This serum offers moderate benefits for your normal skin, with peptides like Sh-Oligopeptide-2 and Palmitoyl Tripeptide-5 supporting skin restoration and firmness, while Sodium Hyaluronate and Glycerin provide general hydration.
- While beneficial for overall skin health, the formula does not specifically target your primary concern of pigmentation, and the inclusion of Glycolic Acid may pose a slight irritation risk.
- The product is generally safe for normal skin, with a focus on supportive ingredients and a low potential for adverse reactions.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/eighth-day/regenerative-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/au/p/eighth-day/regenerative-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/au/p/eighth-day/regenerative-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/au/p/eighth-day/regenerative-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/au/p/eighth-day/regenerative-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/au/p/eighth-day/regenerative-serum/for/dark-spots): Average (this page)
- [Mature skin](https://lovi.care/skincare/au/p/eighth-day/regenerative-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/au/p/eighth-day/regenerative-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/eighth-day/regenerative-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Peptide-Rich Plasma, Sodium Hyaluronate, Niacinamide, Acetyl Glutamine, Manuka Honey

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects. ([Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical insulin combined with fractional CO2 laser showed no significant difference in efficacy compared to topical PRP combined with fractional CO2 laser for atrophic acne scars in 30 patients. ([Archives of Dermatological Research, 2025](https://pubmed.ncbi.nlm.nih.gov/40167803/))
- Subcision and microneedling combined with topical platelet-rich plasma resulted in significantly greater improvement in scar grading compared to subcision and microneedling alone in patients with atrophic scars. ([Journal of Cutaneous and Aesthetic Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/38800810/))
- Platelets remain viable for up to 90 days in a refrigerated cosmetic vehicle with demonstrated topical clinical PRP facial benefits, and 20ml and 60ml PRP volumes are equally efficacious. ([Journal of Drugs in Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33346518/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical overnight application of MGO Manuka Honey microemulsion eye cream significantly reduced symptomology, improved tear film stability and lipid layer thickness, and decreased lid margin staining, ocular Demodex, and bacterial load in patients with blepharitis compared to control eyes. ([The Ocular Surface, 2020](https://pubmed.ncbi.nlm.nih.gov/31759183/))
- Optimel 16% manuka honey eye-drops significantly improved symptoms and objective signs in patients with meibomian gland dysfunction compared to baseline after 3 weeks. ([The British Journal of Ophthalmology, 2022](https://pubmed.ncbi.nlm.nih.gov/33419788/))
- The application of Manuka honey and the GENADYNE A4 negative pressure wound therapy system in a 55-year-old woman with extensive phlegmonous and necrotic lesions following traumatic colonic rupture successfully enabled skin autografting and complete wound healing. ([Medical Science Monitor, 2010](https://pubmed.ncbi.nlm.nih.gov/20980964/))

## Why other serums fit skin with dark spots better

- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))

## What reviewers say

This serum is highly praised for its "Peptide-Rich Plasma" technology, which users credit for rapidly improving skin texture, firmness, and radiance. While many describe it as a "holy grail" for anti-aging and hydration, a subset of users feel the high price tag is not justified by the results, which can be subtle for some.

- Disliked: High price (mostly mentioned)
- Liked: Fast absorption (often mentioned)
- Liked: Visible anti-aging (often mentioned)
- Liked: High-tech ingredients (sometimes noted)
- Liked: Hydration (sometimes noted)
- Disliked: Lack of results (sometimes noted)
- Liked: Packaging (rarely noted)
- Disliked: Availability issues (rarely noted)
- Disliked: No acne benefit (rarely noted)
- Disliked: Texture complaints (rarely noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Eighth Day Regenerative Serum work for skin with dark spots?

This serum works moderately well for your skin, as it provides general hydration and firming benefits, but it does not specifically target dark spots. Skin with dark spots needs products containing effective antioxidants, soothing ingredients, and targeted brighteners like niacinamide to fade discoloration without irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Which ingredients make this serum a good fit for skin with dark spots?

This serum works for skin with dark spots because it contains niacinamide and manuka honey, which help fade pigmentation. For this skin, a treatment product needs soothing ingredients and powerful antioxidants that target dark spots without causing irritation.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### What does Peptide-Rich Plasma do for skin with dark spots?

Platelet-rich plasma injections help fade dark circles under the eyes and improve overall skin color and patient satisfaction. Studies show it can successfully reduce dark spots, though results may vary compared to other treatments.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/31021041/), [Journal of Cosmetic Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24641609/)

### What does Hyaluronic Acid do for skin with dark spots?

Hyaluronic acid is unlikely to directly fade dark spots, but it helps keep dry and uneven skin plump and deeply hydrated. To effectively target dark spots, this type of skin needs brightening ingredients like vitamin C or niacinamide alongside your hydrator.

### Where does this serum go in a skincare routine for skin with dark spots?

This treatment serum goes in the evening routine step after cleansing and before moisturizing, to keep things simple and safe around sun exposure. Skin with dark spots needs products featuring targeted brightening ingredients like vitamin C, retinoids, or gentle acids to effectively fade discoloration.

### Can I use this serum with retinol, and in what order?

You can use this serum in the same routine as retinol by applying it before your retinol, but watch closely for irritation since it contains exfoliating acid. Using a gentle routine with hydrating ingredients helps keep dry or sensitive skin comfortable while layering these active products.

### How often should I use this serum?

This serum works well in an evening routine, starting at once a week and slowly increasing as your skin adjusts. The formula provides moderate benefits for firmness and hydration, but because it does not specifically target dark spots and contains exfoliating acid, skin with dark spots needs a treatment with targeted brightening ingredients like vitamin C or niacinamide to fade discoloration.

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This serum is unlikely to clog pores or cause breakouts for skin with dark spots, as it has a safe formula with a low potential for adverse reactions. However, it does not specifically target dark spots, so a product for this skin needs brightening ingredients like niacinamide and targeted spot-fading agents.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for skin with dark spots

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/au/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dark-spots) — High fit — A$16.95 at Amazon
- [Guerlain Abeille Royale Double R Renew & Repair Serum](https://lovi.care/skincare/au/p/guerlain/abeille-royale-double-r-renew-and-repair-advanced-serum/for/dark-spots) — High fit — A$210.41 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/au/p/la-mer/the-regenerating-serum/for/dark-spots) — High fit — A$740.13 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/au/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — A$13.99 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/au/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — A$23.99 at Amazon
- Moisturizer: [Isntree Green Tea Fresh Serum](https://lovi.care/skincare/au/p/isntree/green-tea-fresh-serum/for/dark-spots) — Superior fit — A$34.00 at Amazon

## Where to buy

No store in Australia has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentylene Glycol, Peptide-Rich Plasma, Sh-Oligopeptide-2, Sh-Polypeptide-1, Sh-Polypeptide-9, Sh-Polypeptide-11, Acetyl Hexapeptide-8, Sh-Oligopeptide-1, Palmitoyl Tripeptide-5, Palmitoyl Tetrapeptide-7, Acetyl Glutamine, Sodium Hyaluronate, Lysine Hcl, Alanine, Histidine Hcl, Arginine, Serine, Proline, Glutamic Acid, Threonine, Valine, Leucine, Glycine, Isoleucine, Phenylalanine, Taurine, Glycerin, Hedychium Coronarium Root Extract, Tripeptide-1, Polygonum Aviculare Extract, Honey, Nonapeptide-1, Acetyl Heptapeptide-4, Phytosphingosine, Sea Whip Extract, Niacinamide, Hydrolyzed Hyaluronic Acid, Aminobutyric Acid, Adenosine, Thioctic Acid, Glycolic Acid, Bacillus Soybean Folic Acid Extract Ferment, Polysorbate 20, Allantoin, Caprylyl Glycol, Lecithin, Butylene Glycol, 1,2-Hexanediol, Dextran, Phenoxyethanol, Ethylhexylglycerin, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/eighth-day/regenerative-serum/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/eighth-day/regenerative-serum/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/eighth-day/regenerative-serum/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/eighth-day/regenerative-serum/for/dark-spots
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- Canada: https://lovi.care/skincare/ca/p/eighth-day/regenerative-serum/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/eighth-day/regenerative-serum/for/dark-spots (this page)
- Singapore: https://lovi.care/skincare/sg/p/eighth-day/regenerative-serum/for/dark-spots
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- United Arab Emirates: https://lovi.care/skincare/ae/p/eighth-day/regenerative-serum/for/dark-spots