# DRMTLGY Needle-less Serum for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/au/p/drmtlgy/needle-less-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [DRMTLGY](https://lovi.care/skincare/au/brands/drmtlgy)
Category: [Serums and treatments](https://lovi.care/skincare/au/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Offers high suitability for your combination skin, as glycerin and sodium hyaluronate provide balanced hydration without overwhelming oilier zones, while niacinamide and peptides support your skin barrier and reduce inflammation associated with acne and breakouts.
- The presence of peptides like Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 contributes to excellent plumping and firming effects, further enhancing the serum's benefits for your skin.
- The formulation is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/drmtlgy/needle-less-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/au/p/drmtlgy/needle-less-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/au/p/drmtlgy/needle-less-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/au/p/drmtlgy/needle-less-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/au/p/drmtlgy/needle-less-serum/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/au/p/drmtlgy/needle-less-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/au/p/drmtlgy/needle-less-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/au/p/drmtlgy/needle-less-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/drmtlgy/needle-less-serum/for/oily-acne-prone-skin): High

## Key ingredients

Sodium Hyaluronate, Niacinamide, Palmitoyl Tripeptide-1, Ceramide Eop, Glycerin

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

While many report softer fine lines and improved texture, critical reviews often note that the "needle-less" claim is marketing hyperbole, as the product functions more as a high-quality hydrating peptide serum than a true alternative to injectables.

- Liked: Hydrating and plumping (mostly mentioned)
- Liked: Excellent texture (often mentioned)
- Liked: Sensitive skin friendly (sometimes noted)
- Liked: Softens fine lines (sometimes noted)
- Disliked: No visible results (sometimes noted)
- Disliked: Price point (rarely noted)
- Disliked: Scent and packaging (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes DRMTLGY Needle-less Serum a great fit for acne-prone skin?

This serum is a great fit because glycerin and sodium hyaluronate give balanced hydration without feeling heavy on oily zones, while niacinamide and peptides calm inflammation and support your skin barrier. It is safe for daily use and is unlikely to cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for acne-prone skin?

Glycerin and sodium hyaluronate make this serum a great fit for your acne-prone skin by providing balanced hydration without making oily areas heavier, while niacinamide and peptides help calm inflammation and support your skin barrier.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### Where does this serum go in a skincare routine for acne-prone skin?

This serum goes in the evening routine after cleansing and before moisturizing. Putting treatments in the evening provides extra safety around sun exposure and keeps your routine simple.

### Can I use it with retinol, and in what order?

Yes, you can use this serum with retinol, applying the treatment in your evening routine before your moisturizer. It is generally safe and unlikely to cause irritation when paired this way.

### How often should I use this serum?

This serum is a great fit for your acne-prone skin, and you can safely use it in the evening as part of your routine. Ingredients like glycerin and sodium hyaluronate help provide balanced hydration while keeping your skin calm and comfortable.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can it clog pores, cause breakouts or purging for acne-prone skin?

This serum is a great fit for acne-prone skin because it uses glycerin and sodium hyaluronate to deliver light hydration that won't clog pores or feel heavy in oily zones. Niacinamide and peptides also help calm inflammation and support your skin barrier without any harsh ingredients that might trigger irritation or breakouts.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/au/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — A$16.95 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/au/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — A$52.32 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/au/p/neogen-dermalogy/real-vitamin-c-serum/for/acne-prone-skin) — Superior fit — A$50.60 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/au/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — A$13.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/au/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — A$34.66 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/au/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — A$24.00 at Amazon

## Where to buy

No store in Australia has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Sodium Chondroitin Sulfate, Sodium Hyaluronate, Pisum Sativum Extract, Bambusa Vulgaris Stem Extract Leaf, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Ceramide Eop, Glucosamine Hcl, Glycosaminoglycans, Ceramide Np, Palmitoyl Tripeptide-5, Ceramide Ap, Phytosphingosine, Cholesterol, Niacinamide, Sodium Lauroyl Lactylate, Methylglucoside Phosphate, Copper Lysinate Prolinate, Panthenol, Phenoxyethanol, Ethylhexylglycerin, Polysorbate 20, Disodium Edta, Butylene Glycol, Carbomer, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/drmtlgy/needle-less-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/drmtlgy/needle-less-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/drmtlgy/needle-less-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/drmtlgy/needle-less-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/drmtlgy/needle-less-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/drmtlgy/needle-less-serum/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/drmtlgy/needle-less-serum/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/drmtlgy/needle-less-serum/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/drmtlgy/needle-less-serum/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/drmtlgy/needle-less-serum/for/acne-prone-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/drmtlgy/needle-less-serum/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/drmtlgy/needle-less-serum/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/drmtlgy/needle-less-serum/for/acne-prone-skin