Derma E Anti-Wrinkle Renewal Cream for dry sensitive skin
Retinol
Bakuchiol
Panthenol Vitamin B5
Tocopheryl Acetate Vitamin E
Carthamus Tinctorius Seed Oil
Average
- AverageDry Skin Fit
- AverageEffectiveness
- Low RiskSafety
Works for dry sensitive skin; other moisturizers fit it better.
This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate moisturizing and anti-aging benefits for your dry and sensitive skin, as glycerin and avocado oil provide emollient action, while retinol helps smooth texture.
- The inclusion of Carthamus Tinctorius Seed Oil and Panthenol Vitamin B5 further supports hydration and soothing, though more potent humectants could enhance results for flaky skin.
- The product is generally safe for your skin, with a low risk of irritation from retinol in moderate concentrations.
How to apply
- Could be used as part of your AM or PM routine. Start using this moisturizer 3 times a week and move to daily use if your dry skin tolerates it well.
- Apply this moisturizer after cleansing and toner in the morning, or after your serum in the evening. Always pair it with SPF in the morning.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing it harshly to protect your sensitive skin.
- Apply the moisturizer on slightly damp skin to help with hydration absorption. This also works well for dry and flaky skin types.
- Do a patch test before your first use. Avoid the eye area to prevent any irritation.
Questions and answers
How well does Derma-E Anti-Wrinkle Renewal Cream work for dry sensitive skin?
This cream works moderately well for dry sensitive skin by offering basic hydration and smoothing texture, though a product of this type needs stronger moisture-holding ingredients and soothing agents to truly stop flaking and fully support this skin type.
Which ingredients make this cream a good fit for dry sensitive skin?
Glycerin and avocado oil provide gentle moisture, while retinol helps smooth texture for dry and sensitive skin. Carthamus tinctorius seed oil and panthenol vitamin B5 further support hydration and calm the skin. A product of this type needs more potent moisture-locking ingredients and soothing agents to best address flaky, sensitive skin.
What does Retinol do for dry sensitive skin?
Retinol is often too strong for dry sensitive skin because it may cause scaling and stinging, so a product of this type needs gentle soothing ingredients and extra moisture to keep the skin calm and smooth.
The British Journal of Dermatology, 2019Toxicology Letters, 2003
What does Bakuchiol do for dry sensitive skin?
Bakuchiol is a gentle, plant-based option that helps smooth lines, improve firmness, and even out skin tone without causing the dryness, redness, or stinging often linked to traditional retinol. It is generally well-tolerated by delicate skin types and helps improve overall moisture and softness with regular use.
Health Science Reports, 2025Journal of Drugs in Dermatology, 2020
Where does it go in a skincare routine for dry sensitive skin?
This treatment goes in the evening routine after cleansing and toning, followed by a moisturizer. This helps keep it simple and adds safety around sun exposure. A product of this type for dry sensitive skin needs stronger hydrating ingredients to better soothe flaky areas.
Can I use this cream with vitamin C, and in what order?
You can use this cream with vitamin C by applying vitamin C first in your morning routine and this treatment at night, as using them separately helps prevent irritation on dry sensitive skin. A product of this type needs stronger water-binding ingredients and rich soothing oils to keep flaky skin fully hydrated and calm.
How often should I use it?
This cream works best as an evening treatment for your dry sensitive skin. Using it in your nighttime routine helps smooth texture while keeping your skin calm and safe from sun exposure.
Journal of Cosmetic Dermatology, 2020Journal of Drugs in Dermatology, 2015
Can this cream clog pores, cause breakouts or purging for dry sensitive skin?
This cream is unlikely to clog pores, but the retinol in it may cause mild peeling or purging when you first start using it. It is generally safe for your skin, though dry and sensitive skin often needs stronger moisture-locking ingredients and soothing agents to prevent flaking.
Can I use it around the eyes or on my body?
You can use this moisturizing treatment on your body and around the eyes, though the skin on the body and eyelids is very different in thickness. It offers moderate anti-aging and moisturizing benefits, but a product for this skin needs stronger moisture-attracting ingredients to better help flaky areas.
Is this cream fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.
What the research says
Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle.
International Journal of Cosmetic Science, 2017Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.
American Journal of Clinical Dermatology, 2002A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.
The Journal of Dermatological Treatment, 2017Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.
The British Journal of Dermatology, 2019Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity.
Journal of Controlled Release, 2018Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle.
Archives of Dermatological Research, 2017Topical application of all-trans-retinol induced epidermal thickening and increased retinoid binding protein expression similar to all-trans-retinoic acid in normal human skin, but without causing significant erythema or measurable retinoic acid levels.
The Journal of Investigative Dermatology, 1995A dermocosmetic containing bakuchiol, Ginkgo biloba extract, and mannitol improves inflammatory lesions, Investigator Global Assessment, and seborrhea intensity when added to adapalene 0.1% gel in patients with acne vulgaris.
Clinical, Cosmetic and Investigational Dermatology, 2015Topical application of a serum containing supramolecular Bakuchiol and Terminalia chebula extract significantly improved barrier function, reduced redness and sensitivity, and improved wrinkles and elasticity in 34 Chinese subjects with sensitive skin after 28 days.
Health Science Reports, 2025Bakuchiol functions as an anti-aging compound through retinol-like regulation of gene expression, producing significant improvements in lines, wrinkles, pigmentation, elasticity, firmness, and photo-damage after 12 weeks of twice-a-day facial application without usual retinol therapy-associated undesirable effects.
International Journal of Cosmetic Science, 2014Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.
Journal of Cosmetic Dermatology, 2019Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans.
Arzneimittel-Forschung, 2000Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two.
Auris, Nasus, Larynx, 2020Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.
Journal of Cosmetic Dermatology, 2025Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.
Contemporary Clinical Trials Communications, 2021Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.
Journal of Cosmetic Dermatology, 2024Safflower oil body-human epidermal growth factor microgel emulsions mixed with xanthan gum enhance transdermal absorption, regulate inflammation, accelerate angiogenesis, and promote re-epithelialization and remodeling in full-layer skin wounds in rats.
International Journal of Biological Macromolecules, 2022
Why other moisturizers fit dry sensitive skin better
- Retinol in this moisturizer
Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.
The British Journal of Dermatology, 2019 Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.
Indian Journal of Pharmaceutical Sciences, 2016Nanoemulsions containing Macadamia integrifolia seed oil successfully enhanced skin hydration and reduced wrinkles in human volunteers, outperforming conventional emulsions in skin hydration enhancement.
Nanomaterials, 2024
Ingredients
Water, Carthamus Tinctorius Seed Oil, Stearic Acid, Glycerin, Glyceryl Stearate Se, Cetyl Alcohol, Microcrystalline Cellulose, Cellulose Gum, Persea Gratissima Oil Avocado Oil, Sesamum Indicum Seed Oil, Helianthus Annuus Seed Oil Sunflower Seed Oil, Bakuchiol, Retinol, Panthenol Vitamin B5, Tocopheryl Acetate Vitamin E, Allantoin, Phenoxyethanol, Ethylhexylglycerin, Oils
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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