Dear, Klairs Midnight Blue Youth Activating Drop for acne-prone skin
Rh-Oligopeptide-1
Sh-Polypeptide-1
Blueberry Fruit Extract
GuaiazuleneHigh
- HighCombination Skin Fit
- HighEffectiveness
- ExcellentSafety
A great choice for acne-prone skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- This product offers excellent skin rejuvenation for your combination skin, as Sh-Oligopeptide-1 and Sh-Polypeptide-1 promote extracellular matrix synthesis to minimize fine lines and wrinkles.
- The inclusion of blueberry fruit extract and Guaiazulene further supports skin regeneration and healing, addressing your concerns with acne, blemishes, and breakouts.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.
How to apply
- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
People Say
★4.4Overall rating based on 1.5k+ reviewsBased on a very large amount of data, this product is widely praised as a lightweight, watery anti-aging serum that absorbs instantly and is exceptionally gentle, making it a favorite for oily and sensitive skin types. Many users report smoother skin texture, reduced redness, and a plump feel. Some find the 20ml bottle too small for the price and note that its preventative anti-aging effects take time to become visible.
Highlights
Rapid absorption Mostly Mentioned
- “absorbs like a dream”
- “drinks it up instantly”
- “leaves no residue”
- “disappears into skin”
Small volume/price Mostly Mentioned
- “finished in 3 weeks”
- “wish it was bigger”
- “pricey for the size”
- “tiny bottle”
Gentle formula Often Mentioned
- “didn't break me out”
- “no stinging”
- “safe for reactive skin”
Soothing & calming Often Mentioned
- “calms my redness”
- “soothing on sensitive skin”
- “helps with irritation”
- “great for post-sun”
Improves texture Sometimes Noted
- “skin feels softer”
- “noticed smoother texture”
- “woke up glowing”
- “pores look smaller”
Slow visible results Sometimes Noted
- “didn't see wrinkle reduction”
- “takes months to work”
- “more preventative than corrective”
- “no dramatic difference”
Watery consistency Sometimes Noted
- “runs off my hand”
- “hard to control dropper”
- “too thin like water”
- “spills easily”
Not moisturizing Rarely Noted
- “need moisturizer on top”
- “feels like just water”
- “not enough hydration”
- “must layer quickly”
Sources: lovi.care, iherb.com, sokoglam.com, wishtrend.com, yesstyle.com, reddit.com, and more
Questions and answers
What makes the Klairs Midnight Blue Youth Activating Drop a great fit for acne-prone skin?
This product is a great fit because blueberry fruit extract and Guaiazulene help soothe and heal acne, blemishes, and breakouts. It has a very safe formula with no harsh ingredients, so it is unlikely to cause irritation on sensitive or breakout-prone skin.
Which ingredients make this serum a good fit for acne-prone skin?
Blueberry fruit extract and Guaiazulene make this serum a great fit for acne-prone skin by helping with regeneration and healing for breakouts. They are joined by soothing ingredients that give it a very safe profile without harsh components that might cause irritation.
What does EGF do for acne-prone skin?
EGF helps calm acne-prone skin by reducing both inflamed and non-inflamed breakouts. It supports skin healing and barrier repair, making it a useful option for improving overall skin texture.
Where does this serum go in a skincare routine for acne-prone skin?
This serum is used in the evening routine. Applying it at night provides extra safety around sun exposure, and its soothing ingredients are unlikely to cause irritation on acne-prone skin.
Can I use this serum with retinol, and in what order?
You can use this treatment alongside retinol by applying the treatment first and following with your retinol once it absorbs. This product has an excellent safety profile with soothing ingredients that help calm the skin, making it unlikely to cause irritation when paired with active routines.
How often should I use this serum?
You can use this treatment in the evening as part of your routine. It is very unlikely to irritate acne-prone skin because it avoids harsh ingredients and features soothing components.
Can this serum clog pores, cause breakouts or purging for acne-prone skin?
This serum is a great fit and is unlikely to clog pores, cause breakouts, or lead to purging on acne-prone skin. It features soothing components and has an excellent safety profile with no harsh ingredients that typically cause irritation.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Topical epidermal growth factor combined with silver sulfadiazine accelerated the rate of epidermal regeneration and significantly decreased healing time by approximately 1 to 1.5 days across all stages of healing in skin-graft-donor sites of 12 patients compared to silver sulfadiazine alone.
The New England Journal of Medicine, 1989Topical recombinant human epidermal growth factor combined with ablative fractional carbon dioxide laser significantly improved striae surface texture and showed significantly greater participant satisfaction regarding marked improvement compared to ablative fractional carbon dioxide laser combined with Aloe vera gel in patients with striae alba.
Lasers in Surgery and Medicine, 2020Topical EGF combined with fractional CO2 laser significantly improves the clinical appearance of atrophic acne scars and decreases skin pigmentation compared to fractional CO2 laser alone in patients with atrophic acne scars.
The Journal of Clinical and Aesthetic Dermatology, 2022Topical application of PTD-EGF and FGF1 increased cell proliferation and collagen accumulation while protecting against UV-induced damage and improving wrinkle parameters in human skin.
Journal of Cosmetic Dermatology, 2013Basic fibroblast growth factor-loaded human serum albumin nanoparticles enhanced the proliferation and migration of human dermal fibroblasts, down-regulated myofibroblast-related genes, and accelerated wound healing with enhanced angiogenesis in vivo compared to unstable native forms.
Journal of Nanobiotechnology, 2023Topical application of basic fibroblast growth factor decreases elevated transepidermal water loss and increases Ki67 expression in keratinocytes following mechanical scratching in a mouse model.
Skin Pharmacology and Physiology, 2013Applying a topical product containing blueberry extract and Pro-xylane following micro-focused ultrasound significantly improved global aesthetic improvement, skin elasticity, and fine lines compared to standard moisturizer in 50 patients.
Journal of Cosmetic Dermatology, 2025Topical usage of blueberries may prevent skin damage from environmental stressors by inducing an active skin response against noxious effects.
Antioxidants, 2023Pretreatment with blueberry extracts prevented ozone-induced ROS production, NLRP1-ASC scaffold formation, and CASP1 and IL-18 transcripts across 2D, 3D, and human skin explant models.
Oxidative Medicine and Cellular Longevity, 2020
Ingredients
Water, Butylene Glycol, Sh-Oligopeptide-1, Sh-Polypeptide-1, Blueberry Fruit Extract, Lecithin, Sorbitan Sesquioleate, 1,2-Hexanediol, Caprylyl Glycol, Peg-60 Hydrogenated Castor Oil, Glycerin, Chlorphenesin, Guaiazulene, Ethylhexylglycerin, Adenosine
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
-
Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
-
Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
-
Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
-
Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
-
Medical Board
Cosmetic chemist, SCS, IFSCC member
-
Medical Board, Medical Advisor
Dermatology MD
-
Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
-
Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
Scan your face, then any product: Lovi shows how well it fits you and what fits even better.