# Biossance Squalane + Phyto-Retinol Serum for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/au/p/biossance/squalane-phyto-retinol-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [Biossance](https://lovi.care/skincare/au/brands/biossance)
Category: [Serums and treatments](https://lovi.care/skincare/au/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your combination skin, as squalane and niacinamide provide emollient action and seboregulation, respectively, though these ingredients primarily offer hydration rather than directly addressing oily shine.
- The serum provides general skincare benefits like hydration and soothing, with bakuchiol and niacinamide contributing to skin smoothing and anti-aging effects, but these are not the primary focus for your main goal of managing oily shine.
- The product is safe for your combination skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components like squalane and niacinamide.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/biossance/squalane-phyto-retinol-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/au/p/biossance/squalane-phyto-retinol-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/au/p/biossance/squalane-phyto-retinol-serum/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/au/p/biossance/squalane-phyto-retinol-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/au/p/biossance/squalane-phyto-retinol-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/au/p/biossance/squalane-phyto-retinol-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/au/p/biossance/squalane-phyto-retinol-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/au/p/biossance/squalane-phyto-retinol-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/biossance/squalane-phyto-retinol-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Squalane, Bakuchiol, Niacinamide, Sodium Hyaluronate, Biosaccharide Gum-1

## What the research says

- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- A dermocosmetic containing bakuchiol, Ginkgo biloba extract, and mannitol improves inflammatory lesions, Investigator Global Assessment, and seborrhea intensity when added to adapalene 0.1% gel in patients with acne vulgaris. ([Clinical, Cosmetic and Investigational Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25914553/))
- Topical application of a serum containing supramolecular Bakuchiol and Terminalia chebula extract significantly improved barrier function, reduced redness and sensitivity, and improved wrinkles and elasticity in 34 Chinese subjects with sensitive skin after 28 days. ([Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/))
- Bakuchiol functions as an anti-aging compound through retinol-like regulation of gene expression, producing significant improvements in lines, wrinkles, pigmentation, elasticity, firmness, and photo-damage after 12 weeks of twice-a-day facial application without usual retinol therapy-associated undesirable effects. ([International Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/24471735/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## Why other serums fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## What reviewers say

Users frequently report improvements in skin texture and significant hydration without the irritation commonly associated with retinoids. Some users find the name misleading and the scent polarizing, while others note the high price and recent availability issues.

- Liked: Gentle, non-irritating (mostly mentioned)
- Liked: Hydrating and moisturizing (often mentioned)
- Disliked: Availability issues (often mentioned)
- Liked: Improves skin texture (sometimes noted)
- Liked: Lightweight formula (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Misleading name (sometimes noted)
- Disliked: Polarizing scent (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Biossance Phyto-Retinol Serum work for combination skin?

Biossance Squalane + Phyto-Retinol Serum works moderately well for combination skin because it provides general hydration and soothing without directly targeting oily shine. A treatment of this type needs ingredients like niacinamide and zinc PCA to manage oiliness while keeping the skin balanced.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)

### Which ingredients make this serum a good fit for combination skin?

Squalane and niacinamide make this serum a good fit by offering gentle hydration and balancing oily shine without causing irritation. To truly excel for this skin, a treatment of this type needs ingredients like zinc PCA or propolis that more directly regulate oiliness.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### What does Squalane do for combination skin?

Squalane helps keep combination skin soft and smooth by locking in moisture without feeling heavy or greasy. It supports the skin barrier and provides lightweight hydration that works well for both dry and oily areas.
Sources: [Skin Health and Disease, 2024](https://pubmed.ncbi.nlm.nih.gov/39355739/), [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/)

### What does Bakuchiol do for combination skin?

Bakuchiol helps smooth wrinkles, fade dark spots, and calm redness while supporting a balanced skin barrier. This plant-based ingredient works well for combination skin by improving firmness and elasticity without causing the scaling or stinging often linked to traditional anti-aging options.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [Health Science Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41424674/)

### Where does this serum go in a skincare routine for combination skin?

This treatment serum goes in the evening routine for combination skin. To properly manage oily shine while keeping the skin smooth, this skin type needs a product focused on oil control and deep pore care.

### Can I use this serum with retinol, and in what order?

You can use this serum alongside a retinol, applying the treatment after your cleansing toner and before your moisturizer. Because this serum features soothing ingredients like squalane and niacinamide, it is unlikely to cause irritation and may help keep your skin calm while using stronger products.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

Apply this treatment in the evening as part of your routine. This timing keeps things simple and provides extra safety around sun exposure, though some serums can also be used in the morning or twice a day.

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts for combination skin, as it contains soothing and lightweight components like squalane and niacinamide with no harsh ingredients. However, it may not actively control oily shine well enough, so combination skin often needs targeted oil-balancing ingredients like salicylic acid or clay to truly keep pores clear.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (linalool, geraniol, and limonene).

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/au/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — A$16.95 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/au/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — A$52.32 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/au/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — A$639.95 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/au/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — A$73.61 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/au/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — A$42.00 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/au/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — A$22.99 at Amazon

## Where to buy

No store in Australia has a checked price for this product, so the page shows none.

## Ingredients

Water, Squalane, Glycerin, Niacinamide, Sodium Acrylates Copolymer, Bakuchiol, Sodium Hyaluronate, Rosa Canina Oil Fruit, Citrus Aurantium Amara Peel Oil, Biosaccharide Gum-1, Lecithin, Hexylene Glycol, Ethylhexylglycerin, Caprylyl Glycol, Phenoxyethanol, Sodium Gluconate, Citric Acid, Linalool, Geraniol, Limonene, Yeast Extract, Amino Acids, Tetrasodium Glutamate Diacetate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/squalane-phyto-retinol-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/squalane-phyto-retinol-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/biossance/squalane-phyto-retinol-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/biossance/squalane-phyto-retinol-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/biossance/squalane-phyto-retinol-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/biossance/squalane-phyto-retinol-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/biossance/squalane-phyto-retinol-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/biossance/squalane-phyto-retinol-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/biossance/squalane-phyto-retinol-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/biossance/squalane-phyto-retinol-serum/for/combination-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/biossance/squalane-phyto-retinol-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/biossance/squalane-phyto-retinol-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/biossance/squalane-phyto-retinol-serum/for/combination-skin