# Biossance Squalane + Ectoin Overnight Rescue for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/au/p/biossance/squalane-ectoin-overnight-rescue/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [Biossance](https://lovi.care/skincare/au/brands/biossance)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/au/best/moisturizers)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few moisturizers fit it even better.

## Why this fit

- Offers excellent moisturizing for your normal skin, as squalane and ectoin hydrate and enhance barrier resilience, directly addressing your redness and irritation.
- The formula provides moderate suitability for normal skin by offering emollient and protective actions, though it may not deliver optimal results in all areas.
- The safety profile is excellent, with no risks of irritation for your sensitive skin due to the absence of harsh ingredients and the presence of soothing ectoin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/biossance/squalane-ectoin-overnight-rescue/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/au/p/biossance/squalane-ectoin-overnight-rescue/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/au/p/biossance/squalane-ectoin-overnight-rescue/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/au/p/biossance/squalane-ectoin-overnight-rescue/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/au/p/biossance/squalane-ectoin-overnight-rescue/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/au/p/biossance/squalane-ectoin-overnight-rescue/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/au/p/biossance/squalane-ectoin-overnight-rescue/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/au/p/biossance/squalane-ectoin-overnight-rescue/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/biossance/squalane-ectoin-overnight-rescue/for/oily-acne-prone-skin): Average

## Key ingredients

Squalane, Ectoin, Glycerin, Shorea Stenoptera Seed Butter, Acetyl Hexapeptide-8

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Combining ectoine and mannitol with UV filters significantly improved protection of squalene oxidation, catalase activity, and trans-UCA compared to UV filters alone in 10 subjects on irradiated areas. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37539499/))
- Topical 7% ectoine during serial 1064-nm Nd:YAG laser therapy produced a greater reduction in skin erythema, improved stratum corneum hydration, reduced transepidermal water loss, and decreased low-echogenic pixels in thirty participants compared to a vehicle control. ([Biomedicines, 2026](https://pubmed.ncbi.nlm.nih.gov/42792808/))
- Regular application of a novel anti-ageing cream containing hyaluronic acid, ectoin, and botanical actives significantly reduced wrinkle depth and length in the periorbital area while demonstrating very good skin tolerance. ([Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))

## What reviewers say

Most users report waking up to soft, plump, and soothed skin without irritation. Those with oily or acne-prone skin occasionally find the formula too rich. This summary is based on a very large amount of data and should definitely be taken into account.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Absorbs well (often mentioned)
- Liked: Plumps and softens (often mentioned)
- Liked: Soothes sensitive skin (often mentioned)
- Disliked: High price point (sometimes noted)
- Disliked: Heavy or greasy (rarely noted)
- Disliked: Jar packaging (rarely noted)
- Disliked: May cause breakouts (rarely noted)

## How to apply

- Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
- Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
- Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
- You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
- Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Biossance Squalane + Ectoin Overnight Rescue a great fit for sensitive skin?

Biossance Squalane + Ectoin Overnight Rescue is a great fit for sensitive skin because it offers wonderful moisture while helping calm redness and irritation. Its very safe formula avoids harsh ingredients and includes soothing ectoin, which helps keep your skin feeling calm and comfortable without irritation.

### Which ingredients make this cream a good fit for sensitive skin?

Squalane and ectoin make this cream a great fit for sensitive skin by giving deep moisture and strengthening your skin barrier to calm redness and irritation. Because the formula lacks harsh ingredients and includes soothing ectoin, it has an excellent safety profile with very low risk of irritation.

### What does Squalane do for sensitive skin?

Squalane helps calm sensitive skin by defending against everyday irritation and keeping it smooth and soft. It is unlikely to cause irritation and supports your skin barrier so it stays comfortable and hydrated.
Sources: [International Journal of Molecular Sciences, 2017](https://pubmed.ncbi.nlm.nih.gov/29280987/)

### What does Ectoin do for sensitive skin?

Ectoin helps calm sensitive skin by strengthening the skin barrier, reducing water loss, and protecting against irritation. It acts as a gentle shield to keep skin hydrated and comfortable.
Sources: [European Journal of Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40742058/), [Clinics in Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18691511/)

### Where does this cream go in a skincare routine for sensitive skin?

This treatment goes in your evening routine after your soothing toner and before your moisturizer. It is a great fit for your sensitive skin because squalane and ectoin hydrate and protect your skin barrier while soothing redness and irritation with very low risk of irritation.

### Can I use this cream with retinol, and in what order?

You can use this moisturizing treatment with retinol by applying the retinol first at night, letting it absorb, and then following with the cream to help calm and protect your skin. This formula has an excellent safety profile with soothing ectoin, making it unlikely to cause irritation when paired with stronger treatments.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

This moisturizing treatment is designed for evening use as part of your routine for sensitive skin. Daily application is unlikely to cause irritation and helps improve hydration and calm redness.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/14571069/)

### Can this cream clog pores, cause breakouts or purging for sensitive skin?

This cream is unlikely to cause breakouts or clog pores for sensitive skin, as reviewers rarely report heavy or greasy feelings or breakouts. Its formula avoids harsh ingredients and includes soothing ectoin to maintain a safe and comfortable experience.

### Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment around the eyes and on your body because its gentle formula has an excellent safety profile with no risks of irritation for sensitive skin.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/au/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/sensitive-skin) — Superior fit — A$32.25 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/au/p/cosrx/advanced-snail-96-mucin-power-essence/for/sensitive-skin) — Superior fit — A$18.90 at Amazon
- [COSRX Advanced Snail 92 All in One Cream](https://lovi.care/skincare/au/p/cosrx/advanced-snail-92-all-in-one-cream/for/sensitive-skin) — Superior fit — A$24.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/au/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — A$73.61 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/au/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — A$54.00 at Amazon
- Moisturizer with Sun Protection: [Bioderma Bioderma Photoderm Mineral SPF 50+](https://lovi.care/skincare/au/p/bioderma/photoderm-mineral-fluide-spf50/for/sensitive-skin) — Superior fit — A$24.49 at Amazon

## Where to buy

No store in Australia has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Squalane, Shorea Stenoptera Seed Butter, Caprylic Capric Triglyceride, C12-16 Alcohols, Sodium Acrylates Copolymer, Ectoin, Jojoba Esters, Acetyl Hexapeptide-8, Magnesium Chloride, Palmitic Acid, Hydrogenated Lecithin, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Lecithin, Sorbitan Isostearate, Tocopherol, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Sodium Gluconate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/squalane-ectoin-overnight-rescue/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/squalane-ectoin-overnight-rescue/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/biossance/squalane-ectoin-overnight-rescue/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/biossance/squalane-ectoin-overnight-rescue/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/biossance/squalane-ectoin-overnight-rescue/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/biossance/squalane-ectoin-overnight-rescue/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/biossance/squalane-ectoin-overnight-rescue/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/biossance/squalane-ectoin-overnight-rescue/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/biossance/squalane-ectoin-overnight-rescue/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/biossance/squalane-ectoin-overnight-rescue/for/sensitive-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/biossance/squalane-ectoin-overnight-rescue/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/biossance/squalane-ectoin-overnight-rescue/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/biossance/squalane-ectoin-overnight-rescue/for/sensitive-skin