# Anua PDRN Hyaluronic Acid Capsule 100 Serum for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/au/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Brand: [Anua](https://lovi.care/skincare/au/brands/anua)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/au/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other moisturizers fit it better.

## Why this fit

- Offers moderate hydration for your combination skin, as multiple forms of hyaluronic acid like Hydrolyzed Hyaluronic Acid and Sodium Hyaluronate Crosspolymer provide deep moisture, while niacinamide helps regulate oil production.
- The serum is generally safe for your acne-prone skin, lacking harsh ingredients that could cause irritation.
- While it provides excellent moisturizing benefits, it lacks specific ingredients to target acne and blemishes directly.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/au/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/au/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/au/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/au/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/au/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/au/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/au/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/au/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/au/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/oily-acne-prone-skin): High

## Key ingredients

Hydrolyzed Hyaluronic Acid, Niacinamide, Glutathione

## What the research says

- Profhilo treatment led to significant improvements in superficial skin hydration and transepidermal water loss over time in Chinese females, while demonstrating good product tolerability. ([Aesthetic Plastic Surgery, 2026](https://pubmed.ncbi.nlm.nih.gov/40921777/))
- Profhilo gel combined with Dysport Botox significantly improved skin hydration, skin thickness, and GAIS scores compared to Dysport Botox injection alone in 19 participants seeking neck rejuvenation. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/35775872/))
- Polyelectrolyte nanocomplexes of quaternized cyclodextrin grafted chitosan and low molecular weight hyaluronic acid improved skin texture and elasticity by increasing skin hydration in clinical evaluation. ([Colloids and Surfaces. B, Biointerfaces, 2022](https://pubmed.ncbi.nlm.nih.gov/36279763/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- RayGel reduced skin reaction severity with a lower average score of 93.7 compared to 123.3 for the placebo group in patients undergoing whole breast external-beam irradiation. ([American Journal of Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/15862509/))

## Why other moisturizers fit acne-prone skin better

- Gluconolactone 14% solution significantly improved mild to moderate acne by reducing inflamed and non-inflamed lesions similarly to 5% benzoyl peroxide, but with fewer side-effects in 150 patients. ([The Australasian Journal of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1303072/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))

## What reviewers say

Users consistently praise this serum for delivering the coveted "glass skin" look, offering deep hydration that plumps the skin without feeling heavy or greasy. While most find it excellent for barrier repair and instant glow, a minority feel it is simply a good hydrator rather than a "life-changing" treatment for the price.

- Liked: Deep hydration (mostly mentioned)
- Liked: Glass skin glow (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Makeup compatibility (sometimes noted)
- Liked: Soothing & repair (sometimes noted)
- Disliked: Price vs volume (sometimes noted)
- Disliked: Breakouts (rarely noted)
- Disliked: Runny consistency (rarely noted)
- Disliked: Subtle results (rarely noted)
- Disliked: Texture issues (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Anua PDRN Hyaluronic Acid Capsule 100 Serum work for acne-prone skin?

This serum works moderately well for your acne-prone skin because it provides deep moisture and helps regulate oil without causing irritation, though it lacks specific ingredients to target breakouts directly. To fit this skin better, a moisturizing treatment needs effective ingredients that address blemishes while keeping oiliness in check.
Sources: [Aesthetic Plastic Surgery, 2026](https://pubmed.ncbi.nlm.nih.gov/40921777/)

### Which ingredients make this serum a good fit for acne-prone skin?

Niacinamide and multiple forms of hyaluronic acid make this serum a fit by helping control oil and providing deep moisture without causing irritation. Acne-prone skin needs products with calming and blemish-targeting ingredients like Centella Asiatica and peptides alongside oil-balancing ingredients.
Sources: [Aesthetic Plastic Surgery, 2026](https://pubmed.ncbi.nlm.nih.gov/40921777/)

### What does Hydrolyzed Hyaluronic Acid do for acne-prone skin?

Hydrolyzed hyaluronic acid helps balance moisture in acne-prone skin while supporting a calm, clear complexion. Depending on its molecular weight and formulation, it may help manage skin oil production and inflammation safely.
Sources: [RSC Advances, 2026](https://pubmed.ncbi.nlm.nih.gov/41659329/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### Where does this serum go in a skincare routine for acne-prone skin?

This serum goes in the evening routine after cleansing and before moisturizing, though some serums may also be used in the morning or twice a day. While it provides good moisture and is generally safe, this skin needs a product containing targeted blemish-fighting ingredients to work best.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying it before your retinol to keep your skin hydrated and help reduce irritation. This product needs soothing ingredients like centella or green tea, and blemish-fighting ingredients like salicylic acid, to truly help acne-prone skin.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this serum?

You can use this serum in your evening routine as an everyday treatment step, and some people may also use it in the morning or twice a day. Daily application helps keep your skin hydrated and smooth while being gentle on acne-prone skin, though this type of skin also needs specific ingredients to target breakouts directly.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to clog pores or cause breakouts for acne-prone skin because it lacks harsh ingredients that typically cause irritation. While it provides good moisture and helps keep skin calm, a product of this type needs specific blemish-fighting ingredients to actively target acne.

### Can I use this serum around the eyes or on my body?

You can use this serum safely around the eyes and on the body because it features a gentle formula with good skin tolerance. While it provides deep moisture with multiple forms of hyaluronic acid, acne-prone skin ultimately needs targeted blemish-fighting ingredients and soothing plant extracts for the best results.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [MEDI-PEEL Peptide 9 Volume White Cica All-in-one Essence](https://lovi.care/skincare/au/p/medi-peel/peptide-9-volume-white-cica-all-in-one-essence/for/acne-prone-skin) — High fit — A$38.48 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/au/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/acne-prone-skin) — High fit — A$42.40 at Amazon
- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/au/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin) — Average fit — A$50.00 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/au/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — A$13.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/au/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — A$34.66 at Amazon
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/au/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/acne-prone-skin) — Superior fit — A$80.43 at Amazon

## Where to buy

- Amazon.com.au: A$36.00 (https://www.amazon.com.au/dp/B0DLB58CWR?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Butylene Glycol, Propanediol, Glycerin, Hydrolyzed Hyaluronic Acid, 1,2-Hexanediol, Niacinamide, Glyceryl Oleate, Lauryl Glucoside, Myristyl Glucoside, Polyglyceryl-6 Laurate, Hydrogenated Lecithin, Glutathione, Hydrolyzed Collagen, Hyaluronic Acid, Coptis Japonica Root Extract, Adenosine, Sodium Dna, Hydrolyzed Sodium Hyaluronate, Hydroxypropyltrimonium Hyaluronate, Potassium Hyaluronate, Sodium Hyaluronate Crosspolymer, Sodium Acetylated Hyaluronate, Melia Azadirachta Leaf Extract, Melia Azadirachta Flower Extract, Coccinia Indica Fruit Extract, Solanum Melongena Fruit Extract, Ocimum Sanctum Leaf Extract, Citric Acid, Curcuma Longa Root Extract, Corallina Officinalis Extract, Sodium Citrate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/acne-prone-skin (this page)
- Singapore: https://lovi.care/skincare/sg/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/anua/pdrn-hyaluronic-acid-capsule-100-serum/for/acne-prone-skin