# Superoxide dismutase and palmitoyl pentapeptide-4

Page: https://lovi.care/skincare/au/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Keep them apart

Use them at different times of day, applying [superoxide dismutase](https://lovi.care/skincare/au/ingredients/superoxide-dismutase) first and [palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/palmitoyl-pentapeptide-4) later, to prevent the enzyme from breaking down the peptide. Superoxide dismutase can act like a pair of scissors, chopping up the peptide and stopping it from smoothing wrinkles. The shopper can separate them by using one in the morning and the other at night.

- [All about superoxide dismutase](https://lovi.care/skincare/au/ingredients/superoxide-dismutase)
- [All about palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/palmitoyl-pentapeptide-4)

### [Superoxide dismutase](https://lovi.care/skincare/au/ingredients/superoxide-dismutase) products

- [iS Clinical Reparative Moisture Emulsion](https://lovi.care/skincare/au/p/is-clinical/reparative-moisture-emulsion/for/dry-skin) — High fit
- [U Beauty Resurfacing Compound](https://lovi.care/skincare/au/p/u-beauty/resurfacing-compound/for/dark-spots) — High fit
- [Skinbetter Science Alto Advanced Defense and Repair Serum](https://lovi.care/skincare/au/p/skinbetter-science/alto-advanced-defense-and-repair-serum/for/dry-sensitive-skin) — High fit
- [Skin Better Science Alto Advanced Defense and Repair Serum](https://lovi.care/skincare/au/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-skin) — High fit
- [Skinbetter Science Alto Defense Serum](https://lovi.care/skincare/au/p/skinbetter-science/alto-defense-serum/for/dark-spots) — High fit
- [NIOD Modulating Glucosides](https://lovi.care/skincare/au/p/niod/modulating-glucosides/for/mature-skin) — High fit
- [Charlotte Tilbury Magic Eye Rescue](https://lovi.care/skincare/au/p/charlotte-tilbury/magic-eye-rescue/for/dark-spots) — Average fit
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/au/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit
- [Image Skincare Vital C Hydrating Enzyme Masque](https://lovi.care/skincare/au/p/image-skincare/vital-c-hydrating-enzyme-masque/for/mature-skin) — High fit
- [NIOD Superoxide Dismutase Saccharide Mist](https://lovi.care/skincare/au/p/niod/superoxide-dismutase-saccharide-mist/for/dry-sensitive-skin) — Average fit
- [Dr. Dennis Gross C + Collagen Biocellulose Brightening Treatment Mask](https://lovi.care/skincare/au/p/dr-dennis-gross/c-collagen-biocellulose-brightening-treatment-mask/for/mature-skin) — High fit

### [Palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/palmitoyl-pentapeptide-4) products

- [Olay Eye Lifting Serum](https://lovi.care/skincare/au/p/olay/eye-lifting-serum/for/dry-skin) — High fit — [A$73.89 at Amazon](https://www.amazon.com.au/dp/B01EHW5MAE?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use superoxide dismutase and palmitoyl pentapeptide-4 together?

Keep [superoxide dismutase](https://lovi.care/skincare/au/ingredients/superoxide-dismutase) and [palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/palmitoyl-pentapeptide-4) apart because enzymes can degrade peptide bonds and render the peptides inactive. Avoid combining enzymatic ingredients with peptides in the same routine.

### Which goes first, superoxide dismutase or palmitoyl pentapeptide-4?

Keep superoxide dismutase and palmitoyl pentapeptide-4 apart because enzymes like superoxide dismutase can degrade peptides.

### Are superoxide dismutase and palmitoyl pentapeptide-4 good for sensitive skin?

Keep superoxide dismutase and palmitoyl pentapeptide-4 apart in your routine because enzymes can break down peptides and make them inactive. Both ingredients individually help improve skin signs, but they should not be combined.

## Research on superoxide dismutase and palmitoyl pentapeptide-4

- [Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin](https://pubmed.ncbi.nlm.nih.gov/18492182/) Palmitoyl pentapeptide-4 · International Journal of Cosmetic Science, 2005
- [Topical application of superoxide dismutase mediated by HIV-TAT peptide attenuates UVB-induced damages in human skin](https://pubmed.ncbi.nlm.nih.gov/27460952/) Superoxide dismutase · European Journal of Pharmaceutics and Biopharmaceutics, 2016
- [Use of the synthetic superoxide dismutase/catalase mimetic EUK-134 to compensate for seasonal antioxidant deficiency by reducing pre-existing lipid peroxides at the human skin surface](https://pubmed.ncbi.nlm.nih.gov/18492138/) Superoxide dismutase · International Journal of Cosmetic Science, 2004
- [Use of a Serum With the Infinite Glow® Device Improves Signs of Facial Aging: A Split-Face Case Report Using VISIA Analysis](https://pubmed.ncbi.nlm.nih.gov/42500768/) Palmitoyl pentapeptide-4 · Cureus, 2026

## Other combinations

- Keep them apart: [Adapalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/adapalene-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Granactive retinoid and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/granactive-retinoid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Hydroxypinacolone retinoate and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Pro-retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/pro-retinol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Retinal and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/retinal-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Retinoid blend and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/retinoid-blend-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/retinol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Tretinoin and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/tretinoin-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Vitamin A and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4)
- Work well together: [Liposome and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/liposome-and-palmitoyl-pentapeptide-4)
- Work well together: [Microcapsule and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/microcapsule-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Vitamin C and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/vitamin-c-and-palmitoyl-pentapeptide-4)
- Work well together: [Betaine and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/betaine-and-palmitoyl-pentapeptide-4)
- Work well together: [Glycerin and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/glycerin-and-palmitoyl-pentapeptide-4)
- Work well together: [Hyaluronic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/hyaluronic-acid-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Niacinamide and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/niacinamide-and-palmitoyl-pentapeptide-4)
- Work well together: [Panthenol and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/panthenol-and-palmitoyl-pentapeptide-4)
- Work well together: [Bakuchiol and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/bakuchiol-and-palmitoyl-pentapeptide-4)
- Work well together: [Arginine and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/arginine-and-palmitoyl-pentapeptide-4)
- Work well together: [GABA and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/gaba-and-palmitoyl-pentapeptide-4)
- Work well together: [Silk amino acids and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/silk-amino-acids-and-palmitoyl-pentapeptide-4)
- Work well together: [Taurine and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/taurine-and-palmitoyl-pentapeptide-4)
- Work well together: [Palmitoyl pentapeptide-4 and theanine](https://lovi.care/skincare/au/ingredients/palmitoyl-pentapeptide-4-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/aha-blend-glycolic-and-citric-acids-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Citric acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/citric-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Glycolic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/glycolic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Lactic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/lactic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Mandelic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/mandelic-acid-and-palmitoyl-pentapeptide-4)
- Work well together: [Coenzyme Q10 and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/coenzyme-q10-and-palmitoyl-pentapeptide-4)
- Work well together: [Green tea and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/green-tea-and-palmitoyl-pentapeptide-4)
- Work well together: [Vitamin E and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4)
- Work well together: [Beta-sitosterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/beta-sitosterol-and-palmitoyl-pentapeptide-4)
- Work well together: [Ceramide-building complex and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/ceramide-building-complex-and-palmitoyl-pentapeptide-4)
- Work well together: [Cholesterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/cholesterol-and-palmitoyl-pentapeptide-4)
- Work well together: [Phytosphingosine and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/phytosphingosine-and-palmitoyl-pentapeptide-4)
- Work well together: [Phytosterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/phytosterol-and-palmitoyl-pentapeptide-4)
- Work well together: [Squalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/squalene-and-palmitoyl-pentapeptide-4)
- Work well together: [Tri-ceramide complex and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/tri-ceramide-complex-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Salicylic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/salicylic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Baking soda and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/baking-soda-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Bleach and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/bleach-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Potassium hydroxide and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/potassium-hydroxide-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Behenyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/behenyl-alcohol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Isopropyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/isopropyl-alcohol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Polyvinyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/polyvinyl-alcohol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Copper and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/copper-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Benzoyl peroxide and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/benzoyl-peroxide-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Magnesium and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/magnesium-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Zinc and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/zinc-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Zinc sulfate and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/zinc-sulfate-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Azelaic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Acetyl hexapeptide-3 and superoxide dismutase](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase)
- Keep them apart: [Bio-placenta peptides and superoxide dismutase](https://lovi.care/skincare/au/ingredients/bio-placenta-peptides-and-superoxide-dismutase)
- Keep them apart: [Superoxide dismutase and collagen peptide](https://lovi.care/skincare/au/ingredients/superoxide-dismutase-and-collagen-peptide)
- Keep them apart: [Superoxide dismutase and copper peptide](https://lovi.care/skincare/au/ingredients/superoxide-dismutase-and-copper-peptide)
- Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/au/ingredients/hexapeptide-and-superoxide-dismutase)
- Keep them apart: [Superoxide dismutase and hexapeptide-9](https://lovi.care/skincare/au/ingredients/superoxide-dismutase-and-hexapeptide-9)
- Keep them apart: [Protease and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/protease-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Superoxide dismutase and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/superoxide-dismutase-and-palmitoyl-tripeptide-1)
- Keep them apart: [Superoxide dismutase and peptide-rich plasma](https://lovi.care/skincare/au/ingredients/superoxide-dismutase-and-peptide-rich-plasma)
- Keep them apart: [Superoxide dismutase and triple peptide blend](https://lovi.care/skincare/au/ingredients/superoxide-dismutase-and-triple-peptide-blend)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4
- United Kingdom: https://lovi.care/skincare/uk/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4
- Ireland: https://lovi.care/skincare/ie/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4
- Germany: https://lovi.care/skincare/de/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4
- France: https://lovi.care/skincare/fr/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4
- Italy: https://lovi.care/skincare/it/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4
- Netherlands: https://lovi.care/skincare/nl/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4
- Spain: https://lovi.care/skincare/es/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4
- Canada: https://lovi.care/skincare/ca/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4
- Australia: https://lovi.care/skincare/au/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4 (this page)
- Singapore: https://lovi.care/skincare/sg/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4