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Retinal and hexapeptide-9

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Retinal and hexapeptide-9: keep them apart

Keep them apart

Use them at different times of day by applying your hexapeptide-9 in the morning and your retinal at night. Using these two active ingredients together in the same routine can cause extra skin irritation and redness. You can avoid this by keeping your retinoid to nighttime and your peptide to daytime use.

Retinal products

Hexapeptide-9 products

Questions and answers

Can you use retinal and hexapeptide-9 together?

No, you should keep retinal and hexapeptide-9 apart in your routine because combining them may increase irritation. Try alternating their usage by applying your retinal in the evening and hexapeptide-9 in the morning.

Which goes first, retinal or hexapeptide-9?

Keep retinal and hexapeptide-9 apart in your routine because combined stimulation may increase irritation. Alternate their usage by applying your retinal in the evening and peptides in the morning.

Are retinal and hexapeptide-9 good for sensitive skin?

Retinal and hexapeptide-9 should be kept apart in your routine because combining them may increase irritation. Try alternating their usage, such as using retinal in the PM and peptides in the AM, especially on mature or sensitive skin.

Research on retinal and hexapeptide-9

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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