# Hexapeptide and protease Page: https://lovi.care/skincare/au/ingredients/hexapeptide-and-protease The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia. Keep them apart Use them at different times of day, applying the peptide product in the morning and the [protease](https://lovi.care/skincare/au/ingredients/protease) at night, because they cancel each other out. Protease breaks down the firming peptides so you miss out on anti-aging results. Separate your usage or use them on alternate nights to get the full benefit. - [All about hexapeptide](https://lovi.care/skincare/au/ingredients/hexapeptide) - [All about protease](https://lovi.care/skincare/au/ingredients/protease) ### [Hexapeptide](https://lovi.care/skincare/au/ingredients/hexapeptide) products - [SkinCeuticals P-TOX](https://lovi.care/skincare/au/p/skinceuticals/p-tox/for/mature-skin) — High fit ### [Protease](https://lovi.care/skincare/au/ingredients/protease) products - [COSRX Centella Cleansing Powder](https://lovi.care/skincare/au/p/cosrx/centella-cleansing-powder/for/combination-skin) — Superior fit - [FANCL Deep Clear Washing Powder](https://lovi.care/skincare/au/p/fancl/deep-clear-washing-powder/for/oily-skin) — High fit — [A$30.00 at Amazon](https://www.amazon.com.au/dp/B091PJNLCB?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1) ## Questions and answers ### Can you use hexapeptide and protease together? No, you should keep [hexapeptide](https://lovi.care/skincare/au/ingredients/hexapeptide) and [protease](https://lovi.care/skincare/au/ingredients/protease) apart in your routine. Proteolytic enzymes may degrade peptide bonds and render the active ingredients inactive. ### Which goes first, hexapeptide or protease? Keep hexapeptide and protease apart in your routine because proteases degrade peptide bonds and render the hexapeptide inactive. ### Are hexapeptide and protease good for sensitive skin? Keep hexapeptide and protease apart in your routine because proteolytic enzymes can degrade peptide bonds and render the active peptides inactive. There are no specific restrictions for sensitive skin types, but combining these two ingredients in the same routine should be avoided. ## Research on hexapeptide and protease - [Preparation and functional evaluation of collagen oligopeptide-rich hydrolysate from fish skin with the serine collagenolytic protease from Pseudoalteromonas sp. SM9913](https://pubmed.ncbi.nlm.nih.gov/29146927/) Protease · Scientific Reports, 2017 - [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Hexapeptide · American Journal of Clinical Dermatology, 2013 - [A randomized, single-blinded trial of a tripeptide/hexapeptide healing regimen following laser resurfacing of the face](https://pubmed.ncbi.nlm.nih.gov/28371204/) Hexapeptide · Journal of Cosmetic Dermatology, 2017 - [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Hexapeptide · Annals of Dermatology, 2019 ## Other combinations - Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/au/ingredients/adapalene-and-hexapeptide) - Keep them apart: [Hexapeptide and granactive retinoid](https://lovi.care/skincare/au/ingredients/hexapeptide-and-granactive-retinoid) - Keep them apart: [Hexapeptide and hydroxypinacolone retinoate](https://lovi.care/skincare/au/ingredients/hexapeptide-and-hydroxypinacolone-retinoate) - Keep them apart: [Hexapeptide and pro-retinol](https://lovi.care/skincare/au/ingredients/hexapeptide-and-pro-retinol) - Keep them apart: [Hexapeptide and retinal](https://lovi.care/skincare/au/ingredients/hexapeptide-and-retinal) - Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/au/ingredients/hexapeptide-and-retinoid-blend) - Depends on the strength: [Retinol and hexapeptide](https://lovi.care/skincare/au/ingredients/retinol-and-hexapeptide) - Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/au/ingredients/tretinoin-and-hexapeptide) - Keep them apart: [Hexapeptide and vitamin A](https://lovi.care/skincare/au/ingredients/hexapeptide-and-vitamin-a) - Work well together: [Hexapeptide and liposome](https://lovi.care/skincare/au/ingredients/hexapeptide-and-liposome) - Work well together: [Hexapeptide and microcapsule](https://lovi.care/skincare/au/ingredients/hexapeptide-and-microcapsule) - Depends on the strength: [Vitamin C and hexapeptide](https://lovi.care/skincare/au/ingredients/vitamin-c-and-hexapeptide) - Work well together: [Hexapeptide and betaine](https://lovi.care/skincare/au/ingredients/hexapeptide-and-betaine) - Work well together: [Glycerin and hexapeptide](https://lovi.care/skincare/au/ingredients/glycerin-and-hexapeptide) - Work well together: [Hexapeptide and hyaluronic acid](https://lovi.care/skincare/au/ingredients/hexapeptide-and-hyaluronic-acid) - Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/au/ingredients/niacinamide-and-hexapeptide) - Work well together: [Panthenol and hexapeptide](https://lovi.care/skincare/au/ingredients/panthenol-and-hexapeptide) - Work well together: [Bakuchiol and hexapeptide](https://lovi.care/skincare/au/ingredients/bakuchiol-and-hexapeptide) - Work well together: [Hexapeptide and arginine](https://lovi.care/skincare/au/ingredients/hexapeptide-and-arginine) - Work well together: [Hexapeptide and GABA](https://lovi.care/skincare/au/ingredients/hexapeptide-and-gaba) - Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/au/ingredients/hexapeptide-and-silk-amino-acids) - Work well together: [Hexapeptide and taurine](https://lovi.care/skincare/au/ingredients/hexapeptide-and-taurine) - Work well together: [Hexapeptide and theanine](https://lovi.care/skincare/au/ingredients/hexapeptide-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and hexapeptide](https://lovi.care/skincare/au/ingredients/aha-blend-glycolic-and-citric-acids-and-hexapeptide) - Keep them apart: [Hexapeptide and citric acid](https://lovi.care/skincare/au/ingredients/hexapeptide-and-citric-acid) - Keep them apart: [Glycolic acid and hexapeptide](https://lovi.care/skincare/au/ingredients/glycolic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/au/ingredients/hexapeptide-and-lactic-acid) - Keep them apart: [Hexapeptide and mandelic acid](https://lovi.care/skincare/au/ingredients/hexapeptide-and-mandelic-acid) - Work well together: [Coenzyme Q10 and hexapeptide](https://lovi.care/skincare/au/ingredients/coenzyme-q10-and-hexapeptide) - Work well together: [Green tea and hexapeptide](https://lovi.care/skincare/au/ingredients/green-tea-and-hexapeptide) - Work well together: [Vitamin E and hexapeptide](https://lovi.care/skincare/au/ingredients/vitamin-e-and-hexapeptide) - Work well together: [Hexapeptide and beta-sitosterol](https://lovi.care/skincare/au/ingredients/hexapeptide-and-beta-sitosterol) - Work well together: [Ceramide-building complex and hexapeptide](https://lovi.care/skincare/au/ingredients/ceramide-building-complex-and-hexapeptide) - Work well together: [Hexapeptide and cholesterol](https://lovi.care/skincare/au/ingredients/hexapeptide-and-cholesterol) - Work well together: [Hexapeptide and phytosphingosine](https://lovi.care/skincare/au/ingredients/hexapeptide-and-phytosphingosine) - Work well together: [Hexapeptide and phytosterol](https://lovi.care/skincare/au/ingredients/hexapeptide-and-phytosterol) - Work well together: [Hexapeptide and squalene](https://lovi.care/skincare/au/ingredients/hexapeptide-and-squalene) - Work well together: [Hexapeptide and tri-ceramide complex](https://lovi.care/skincare/au/ingredients/hexapeptide-and-tri-ceramide-complex) - Keep them apart: [Salicylic acid and hexapeptide](https://lovi.care/skincare/au/ingredients/salicylic-acid-and-hexapeptide) - Keep them apart: [Hexapeptide and baking soda](https://lovi.care/skincare/au/ingredients/hexapeptide-and-baking-soda) - Keep them apart: [Hexapeptide and bleach](https://lovi.care/skincare/au/ingredients/hexapeptide-and-bleach) - Keep them apart: [Hexapeptide and potassium hydroxide](https://lovi.care/skincare/au/ingredients/hexapeptide-and-potassium-hydroxide) - Keep them apart: [Hexapeptide and behenyl alcohol](https://lovi.care/skincare/au/ingredients/hexapeptide-and-behenyl-alcohol) - Keep them apart: [Hexapeptide and isopropyl alcohol](https://lovi.care/skincare/au/ingredients/hexapeptide-and-isopropyl-alcohol) - Keep them apart: [Hexapeptide and polyvinyl alcohol](https://lovi.care/skincare/au/ingredients/hexapeptide-and-polyvinyl-alcohol) - Keep them apart: [Hexapeptide and copper](https://lovi.care/skincare/au/ingredients/hexapeptide-and-copper) - Keep them apart: [Hexapeptide and magnesium](https://lovi.care/skincare/au/ingredients/hexapeptide-and-magnesium) - Keep them apart: [Hexapeptide and zinc](https://lovi.care/skincare/au/ingredients/hexapeptide-and-zinc) - Keep them apart: [Hexapeptide and zinc sulfate](https://lovi.care/skincare/au/ingredients/hexapeptide-and-zinc-sulfate) - Keep them apart: [Benzoyl peroxide and hexapeptide](https://lovi.care/skincare/au/ingredients/benzoyl-peroxide-and-hexapeptide) - Keep them apart: [Azelaic acid and hexapeptide](https://lovi.care/skincare/au/ingredients/azelaic-acid-and-hexapeptide) - Keep them apart: [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-protease) - Keep them apart: [Bio-placenta peptides and protease](https://lovi.care/skincare/au/ingredients/bio-placenta-peptides-and-protease) - Keep them apart: [Collagen peptide and protease](https://lovi.care/skincare/au/ingredients/collagen-peptide-and-protease) - Keep them apart: [Copper peptide and protease](https://lovi.care/skincare/au/ingredients/copper-peptide-and-protease) - Keep them apart: [Hexapeptide and superoxide dismutase](https://lovi.care/skincare/au/ingredients/hexapeptide-and-superoxide-dismutase) - Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/au/ingredients/hexapeptide-9-and-protease) - Keep them apart: [Protease and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/protease-and-palmitoyl-pentapeptide-4) - Keep them apart: [Protease and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/protease-and-palmitoyl-tripeptide-1) - Keep them apart: [Peptide-rich plasma and protease](https://lovi.care/skincare/au/ingredients/peptide-rich-plasma-and-protease) - Keep them apart: [Protease and triple peptide blend](https://lovi.care/skincare/au/ingredients/protease-and-triple-peptide-blend) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/hexapeptide-and-protease - United Kingdom: https://lovi.care/skincare/uk/ingredients/hexapeptide-and-protease - Ireland: https://lovi.care/skincare/ie/ingredients/hexapeptide-and-protease - Germany: https://lovi.care/skincare/de/ingredients/hexapeptide-and-protease - France: https://lovi.care/skincare/fr/ingredients/hexapeptide-and-protease - Italy: https://lovi.care/skincare/it/ingredients/hexapeptide-and-protease - Netherlands: https://lovi.care/skincare/nl/ingredients/hexapeptide-and-protease - Spain: https://lovi.care/skincare/es/ingredients/hexapeptide-and-protease - Canada: https://lovi.care/skincare/ca/ingredients/hexapeptide-and-protease - Australia: https://lovi.care/skincare/au/ingredients/hexapeptide-and-protease (this page) - Singapore: https://lovi.care/skincare/sg/ingredients/hexapeptide-and-protease - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/hexapeptide-and-protease - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/hexapeptide-and-protease