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Benzoyl peroxide and hydroxypinacolone retinoate

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Benzoyl peroxide and hydroxypinacolone retinoate: keep them apart

Keep them apart

Use them at different times of day, applying benzoyl peroxide in the morning and hydroxypinacolone retinoate at night, because they cancel each other out. Benzoyl peroxide oxidizes the retinoid and stops it from working properly. The shopper can switch to using them on alternate nights or pick a gentler strength.

Retinoids: a journey from the molecular structures and mechanisms of action to clinical uses in dermatology and adverse effectsWhy Topical Retinoids Are Mainstay of Therapy for Acne

Benzoyl peroxide products

Hydroxypinacolone retinoate products

Questions and answers

Can you use benzoyl peroxide and hydroxypinacolone retinoate together?

No, you should keep benzoyl peroxide and hydroxypinacolone retinoate apart because benzoyl peroxide causes oxidation and deactivation of retinoids. To use both, apply benzoyl peroxide in the morning and your retinoid at night.

Which goes first, benzoyl peroxide or hydroxypinacolone retinoate?

Keep benzoyl peroxide and hydroxypinacolone retinoate apart in your routine because benzoyl peroxide causes oxidation and deactivation of retinoids. Use benzoyl peroxide in the morning and hydroxypinacolone retinoate in the evening.

Are benzoyl peroxide and hydroxypinacolone retinoate good for sensitive skin?

No, you should keep benzoyl peroxide and hydroxypinacolone retinoate apart in your routine because benzoyl peroxide causes oxidation and deactivation of retinoids. To use both, apply benzoyl peroxide in the morning and your retinoid at night.

Research on benzoyl peroxide and hydroxypinacolone retinoate

Behind this pairing advice

Lovi checks every pairing with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sof铆a Perea P茅rez, MD, MSc

    Dr. Sof铆a Perea P茅rez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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