# Adapalene and palmitoyl tripeptide-1 Page: https://lovi.care/skincare/au/ingredients/adapalene-and-palmitoyl-tripeptide-1 The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia. Keep them apart Use them at different times of day by applying [palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/palmitoyl-tripeptide-1) in the morning and [adapalene](https://lovi.care/skincare/au/ingredients/adapalene) at night. Using both together can cause extra skin irritation because they are both very active. You can prevent this by switching to a lower strength or giving your skin more time between them. - [All about adapalene](https://lovi.care/skincare/au/ingredients/adapalene) - [All about palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/palmitoyl-tripeptide-1) ### [Adapalene](https://lovi.care/skincare/au/ingredients/adapalene) products - [Differin Gel](https://lovi.care/skincare/au/p/differin/gel/for/oily-acne-prone-skin) — High fit - [Galderma Epiduo Gel](https://lovi.care/skincare/au/p/galderma/epiduo-gel/for/acne-prone-skin) — High fit - [La Roche-Posay Effaclar Adapalene Gel 0.1% Acne Treatment](https://lovi.care/skincare/au/p/la-roche-posay/effaclar-adapalene-gel-0-1-acne-treatment/for/oily-skin) — Superior fit ### [Palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/palmitoyl-tripeptide-1) products - [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/au/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit — [A$54.10 at Amazon](https://www.amazon.com.au/dp/B0C9DXGXZ3?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1) - [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/au/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit — [A$29.90 at Amazon](https://www.amazon.com.au/dp/B0BLHW7JZM?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1) - [Medik8 Liquid Peptides](https://lovi.care/skincare/au/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit — [A$105.10 at Amazon](https://www.amazon.com.au/dp/B07YRY7P81?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1) - [Shiseido Benefiance Wrinkle Smoothing Eye Cream](https://lovi.care/skincare/au/p/shiseido/benefiance-wrinkle-smoothing-eye-cream/for/mature-skin) — High fit - [Clinique Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/au/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit — [A$149.95 at Amazon](https://www.amazon.com.au/dp/B09FG8TJDD?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1) - [Alastin Skincare Regenerating Skin Nectar](https://lovi.care/skincare/au/p/alastin-skincare/regenerating-skin-nectar/for/mature-skin) — Superior fit - [The Ordinary Matrixyl 10% + HA](https://lovi.care/skincare/au/p/the-ordinary/matrixyl-10-ha/for/dry-skin) — Superior fit — [A$18.00 at Amazon](https://www.amazon.com.au/dp/B071J1PBQ6?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1) - [ZO Skin Health Daily Power Defense](https://lovi.care/skincare/au/p/zo-skin-health/daily-power-defense/for/oily-skin) — High fit - [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/au/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin) — High fit - [Alastin Ultra Nourishing Moisturizer](https://lovi.care/skincare/au/p/alastin/ultra-nourishing-moisturizer/for/dry-skin) — Superior fit - [DRMTLGY Needle-less Serum](https://lovi.care/skincare/au/p/drmtlgy/needle-less-serum/for/dry-skin) — Superior fit - [Valmont Prime Renewing Pack](https://lovi.care/skincare/au/p/valmont/prime-renewing-pack/for/mature-skin) — High fit ## Questions and answers ### Can you use adapalene and palmitoyl tripeptide-1 together? Keep [adapalene](https://lovi.care/skincare/au/ingredients/adapalene) and [palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/palmitoyl-tripeptide-1) apart because combined stimulation may increase irritation. Alternate usage by applying your retinoid in the PM and peptides in the AM. ### Which goes first, adapalene or palmitoyl tripeptide-1? Keep adapalene and palmitoyl tripeptide-1 apart in your routine because combining them may increase irritation. Use adapalene in the evening and palmitoyl tripeptide-1 in the morning. ### Are adapalene and palmitoyl tripeptide-1 good for sensitive skin? Keep adapalene and palmitoyl tripeptide-1 apart in your routine, as combining strong retinoids like adapalene with peptides may increase irritation on sensitive skin. Instead, alternate their usage by applying your retinoid in the PM and peptides in the AM. ## Research on adapalene and palmitoyl tripeptide-1 - [Prevention and Reduction of Atrophic Acne Scars with Adapalene 0.3%/Benzoyl Peroxide 2.5% Gel in Subjects with Moderate or Severe Facial Acne: Results of a 6-Month Randomized, Vehicle-Controlled Trial Using Intra-Individual Comparison](https://pubmed.ncbi.nlm.nih.gov/29549588/) Adapalene · American Journal of Clinical Dermatology, 2018 - [Efficacy and Safety of a Fixed-Dose Clindamycin Phosphate 1.2%, Benzoyl Peroxide 3.1%, and Adapalene 0.15% Gel for Moderate-to-Severe Acne: A Randomized Phase II Study of the First Triple-Combination Drug](https://pubmed.ncbi.nlm.nih.gov/34674160/) Adapalene · American Journal of Clinical Dermatology, 2022 - [A topical gel of tea tree oil nanoemulsion containing adapalene versus adapalene marketed gel in patients with acne vulgaris: a randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/34251536/) Adapalene · Archives of Dermatological Research, 2022 - [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2015 - [Clindamycin phosphate 1.2%/adapalene 0.15%/benzoyl peroxide 3.1% gel for moderate-to-severe acne: Efficacy and safety results from two randomized phase 3 trials](https://pubmed.ncbi.nlm.nih.gov/37656094/) Adapalene · Journal of the American Academy of Dermatology, 2023 - [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026 - [Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking](https://pubmed.ncbi.nlm.nih.gov/42683869/) Palmitoyl tripeptide-1 · International Journal of Cosmetic Science, 2026 ## Other combinations - Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/adapalene-and-acetyl-hexapeptide-3) - Keep them apart: [Adapalene and bio-placenta peptides](https://lovi.care/skincare/au/ingredients/adapalene-and-bio-placenta-peptides) - Keep them apart: [Adapalene and collagen peptide](https://lovi.care/skincare/au/ingredients/adapalene-and-collagen-peptide) - Keep them apart: [Adapalene and copper peptide](https://lovi.care/skincare/au/ingredients/adapalene-and-copper-peptide) - Keep them apart: [Adapalene and hexapeptide](https://lovi.care/skincare/au/ingredients/adapalene-and-hexapeptide) - Keep them apart: [Adapalene and hexapeptide-9](https://lovi.care/skincare/au/ingredients/adapalene-and-hexapeptide-9) - Keep them apart: [Adapalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/adapalene-and-palmitoyl-pentapeptide-4) - Keep them apart: [Granactive retinoid and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/granactive-retinoid-and-palmitoyl-tripeptide-1) - Keep them apart: [Hydroxypinacolone retinoate and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-tripeptide-1) - Keep them apart: [Pro-retinol and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/pro-retinol-and-palmitoyl-tripeptide-1) - Keep them apart: [Retinal and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/retinal-and-palmitoyl-tripeptide-1) - Keep them apart: [Retinoid blend and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/retinoid-blend-and-palmitoyl-tripeptide-1) - Depends on the strength: [Retinol and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/retinol-and-palmitoyl-tripeptide-1) - Keep them apart: [Tretinoin and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/tretinoin-and-palmitoyl-tripeptide-1) - Keep them apart: [Vitamin A and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/vitamin-a-and-palmitoyl-tripeptide-1) - Keep them apart: [Adapalene and peptide-rich plasma](https://lovi.care/skincare/au/ingredients/adapalene-and-peptide-rich-plasma) - Keep them apart: [Adapalene and triple peptide blend](https://lovi.care/skincare/au/ingredients/adapalene-and-triple-peptide-blend) - Work well together: [Liposome and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/liposome-and-palmitoyl-tripeptide-1) - Work well together: [Microcapsule and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/microcapsule-and-palmitoyl-tripeptide-1) - Depends on the strength: [Vitamin C and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/vitamin-c-and-palmitoyl-tripeptide-1) - Depends on the strength: [Adapalene and niacinamide](https://lovi.care/skincare/au/ingredients/adapalene-and-niacinamide) - Work well together: [Betaine and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/betaine-and-palmitoyl-tripeptide-1) - Work well together: [Glycerin and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/glycerin-and-palmitoyl-tripeptide-1) - Work well together: [Hyaluronic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/hyaluronic-acid-and-palmitoyl-tripeptide-1) - Depends on the strength: [Niacinamide and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/niacinamide-and-palmitoyl-tripeptide-1) - Work well together: [Panthenol and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/panthenol-and-palmitoyl-tripeptide-1) - Work well together: [Bakuchiol and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/bakuchiol-and-palmitoyl-tripeptide-1) - Work well together: [Arginine and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/arginine-and-palmitoyl-tripeptide-1) - Work well together: [GABA and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/gaba-and-palmitoyl-tripeptide-1) - Work well together: [Silk amino acids and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/silk-amino-acids-and-palmitoyl-tripeptide-1) - Work well together: [Taurine and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/taurine-and-palmitoyl-tripeptide-1) - Work well together: [Palmitoyl tripeptide-1 and theanine](https://lovi.care/skincare/au/ingredients/palmitoyl-tripeptide-1-and-theanine) - Keep them apart: [AHA blend glycolic and citric acids and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/aha-blend-glycolic-and-citric-acids-and-palmitoyl-tripeptide-1) - Keep them apart: [Citric acid and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/citric-acid-and-palmitoyl-tripeptide-1) - Keep them apart: [Glycolic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/glycolic-acid-and-palmitoyl-tripeptide-1) - Keep them apart: [Lactic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/lactic-acid-and-palmitoyl-tripeptide-1) - Keep them apart: [Mandelic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/mandelic-acid-and-palmitoyl-tripeptide-1) - Work well together: [Coenzyme Q10 and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/coenzyme-q10-and-palmitoyl-tripeptide-1) - Work well together: [Green tea and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/green-tea-and-palmitoyl-tripeptide-1) - Work well together: [Vitamin E and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/vitamin-e-and-palmitoyl-tripeptide-1) - Keep them apart: [Adapalene and aha blend glycolic and citric acids](https://lovi.care/skincare/au/ingredients/adapalene-and-aha-blend-glycolic-and-citric-acids) - Keep them apart: [Adapalene and citric acid](https://lovi.care/skincare/au/ingredients/adapalene-and-citric-acid) - Keep them apart: [Adapalene and glycolic acid](https://lovi.care/skincare/au/ingredients/adapalene-and-glycolic-acid) - Keep them apart: [Adapalene and lactic acid](https://lovi.care/skincare/au/ingredients/adapalene-and-lactic-acid) - Keep them apart: [Adapalene and mandelic acid](https://lovi.care/skincare/au/ingredients/adapalene-and-mandelic-acid) - Work well together: [Beta-sitosterol and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/beta-sitosterol-and-palmitoyl-tripeptide-1) - Work well together: [Ceramide-building complex and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/ceramide-building-complex-and-palmitoyl-tripeptide-1) - Work well together: [Cholesterol and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/cholesterol-and-palmitoyl-tripeptide-1) - Work well together: [Phytosphingosine and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/phytosphingosine-and-palmitoyl-tripeptide-1) - Work well together: [Phytosterol and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/phytosterol-and-palmitoyl-tripeptide-1) - Work well together: [Squalene and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/squalene-and-palmitoyl-tripeptide-1) - Work well together: [Tri-ceramide complex and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/tri-ceramide-complex-and-palmitoyl-tripeptide-1) - Keep them apart: [Salicylic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/salicylic-acid-and-palmitoyl-tripeptide-1) - Keep them apart: [Adapalene and salicylic acid](https://lovi.care/skincare/au/ingredients/adapalene-and-salicylic-acid) - Keep them apart: [Adapalene and vitamin C](https://lovi.care/skincare/au/ingredients/adapalene-and-vitamin-c) - Keep them apart: [Baking soda and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/baking-soda-and-palmitoyl-tripeptide-1) - Keep them apart: [Bleach and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/bleach-and-palmitoyl-tripeptide-1) - Keep them apart: [Potassium hydroxide and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/potassium-hydroxide-and-palmitoyl-tripeptide-1) - Keep them apart: [Behenyl alcohol and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/behenyl-alcohol-and-palmitoyl-tripeptide-1) - Keep them apart: [Isopropyl alcohol and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/isopropyl-alcohol-and-palmitoyl-tripeptide-1) - Keep them apart: [Polyvinyl alcohol and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/polyvinyl-alcohol-and-palmitoyl-tripeptide-1) - Keep them apart: [Copper and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/copper-and-palmitoyl-tripeptide-1) - Keep them apart: [Adapalene and benzoyl peroxide](https://lovi.care/skincare/au/ingredients/adapalene-and-benzoyl-peroxide) - Keep them apart: [Benzoyl peroxide and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/benzoyl-peroxide-and-palmitoyl-tripeptide-1) - Keep them apart: [Magnesium and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/magnesium-and-palmitoyl-tripeptide-1) - Keep them apart: [Zinc and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/zinc-and-palmitoyl-tripeptide-1) - Keep them apart: [Zinc sulfate and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/zinc-sulfate-and-palmitoyl-tripeptide-1) - Keep them apart: [Azelaic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/azelaic-acid-and-palmitoyl-tripeptide-1) - Keep them apart: [Protease and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/protease-and-palmitoyl-tripeptide-1) - Keep them apart: [Superoxide dismutase and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/superoxide-dismutase-and-palmitoyl-tripeptide-1) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/adapalene-and-palmitoyl-tripeptide-1 - United Kingdom: https://lovi.care/skincare/uk/ingredients/adapalene-and-palmitoyl-tripeptide-1 - Ireland: https://lovi.care/skincare/ie/ingredients/adapalene-and-palmitoyl-tripeptide-1 - Germany: https://lovi.care/skincare/de/ingredients/adapalene-and-palmitoyl-tripeptide-1 - France: https://lovi.care/skincare/fr/ingredients/adapalene-and-palmitoyl-tripeptide-1 - Italy: https://lovi.care/skincare/it/ingredients/adapalene-and-palmitoyl-tripeptide-1 - Netherlands: https://lovi.care/skincare/nl/ingredients/adapalene-and-palmitoyl-tripeptide-1 - Spain: https://lovi.care/skincare/es/ingredients/adapalene-and-palmitoyl-tripeptide-1 - Canada: https://lovi.care/skincare/ca/ingredients/adapalene-and-palmitoyl-tripeptide-1 - Australia: https://lovi.care/skincare/au/ingredients/adapalene-and-palmitoyl-tripeptide-1 (this page) - Singapore: https://lovi.care/skincare/sg/ingredients/adapalene-and-palmitoyl-tripeptide-1 - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/adapalene-and-palmitoyl-tripeptide-1 - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/adapalene-and-palmitoyl-tripeptide-1