# Acetyl hexapeptide-3 and protease

Page: https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-protease

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Australia.

Keep them apart

Use them at different times of day, applying [acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3) in the morning and [protease](https://lovi.care/skincare/au/ingredients/protease) at night, because they clash when mixed. Protease breaks down the firming bonds of acetyl hexapeptide-3, ruining the anti-aging benefits you want to see. You can easily fix this by applying them hours apart or on alternate days.

- [All about acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3)
- [All about protease](https://lovi.care/skincare/au/ingredients/protease)

### [Acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3) products

- [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/au/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit — [A$54.10 at Amazon](https://www.amazon.com.au/dp/B0C9DXGXZ3?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)
- [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/au/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit — [A$29.90 at Amazon](https://www.amazon.com.au/dp/B0BLHW7JZM?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)
- [Medik8 Liquid Peptides](https://lovi.care/skincare/au/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit — [A$105.10 at Amazon](https://www.amazon.com.au/dp/B07YRY7P81?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)
- [La Mer The Treatment Lotion](https://lovi.care/skincare/au/p/la-mer/the-treatment-lotion/for/mature-skin) — Superior fit — [A$250.99 at Amazon](https://www.amazon.com.au/dp/B0B61KKT4K?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)
- [Rhode Peptide Glazing Fluid](https://lovi.care/skincare/au/p/rhode/peptide-glazing-fluid/for/mature-skin) — High fit — [A$85.17 at Amazon](https://www.amazon.com.au/dp/B0GNNW5QV3?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)
- [The Ordinary Argireline Solution 10%](https://lovi.care/skincare/au/p/the-ordinary/argireline-solution-10/for/mature-skin) — Average fit — [A$16.10 at Amazon](https://www.amazon.com.au/dp/B072JH13CD?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)
- [Good Molecules Super Peptide Serum](https://lovi.care/skincare/au/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit
- [Clinique Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/au/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit — [A$149.95 at Amazon](https://www.amazon.com.au/dp/B09FG8TJDD?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)
- [La Mer The Renewal Oil](https://lovi.care/skincare/au/p/la-mer/the-renewal-oil/for/mature-skin) — High fit — [A$521.95 at Amazon](https://www.amazon.com.au/dp/B0163GAMI4?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)
- [Estée Lauder Micro Essence Treatment Lotion](https://lovi.care/skincare/au/p/estee-lauder/micro-essence-treatment-lotion/for/oily-acne-prone-skin) — Superior fit
- [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/au/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin) — High fit
- [La Mer The Eye Concentrate](https://lovi.care/skincare/au/p/la-mer/the-eye-concentrate/for/mature-skin) — High fit — [A$298.95 at Amazon](https://www.amazon.com.au/dp/B085614WX5?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)

### [Protease](https://lovi.care/skincare/au/ingredients/protease) products

- [COSRX Centella Cleansing Powder](https://lovi.care/skincare/au/p/cosrx/centella-cleansing-powder/for/combination-skin) — Superior fit
- [FANCL Deep Clear Washing Powder](https://lovi.care/skincare/au/p/fancl/deep-clear-washing-powder/for/oily-skin) — High fit — [A$30.00 at Amazon](https://www.amazon.com.au/dp/B091PJNLCB?tag=lovi-care-web-product-22&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use acetyl hexapeptide-3 and protease together?

No, you should keep [acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3) and [protease](https://lovi.care/skincare/au/ingredients/protease) apart because proteases degrade peptide bonds and render the active peptide inactive. Avoid using these two ingredients in the same routine.

### Which goes first, acetyl hexapeptide-3 or protease?

Keep acetyl hexapeptide-3 and protease apart in your routine because the protease degrades the peptide bonds and renders the active inactive. If you use both, apply them at completely different times of day to avoid breaking down the peptide.

### Are acetyl hexapeptide-3 and protease good for sensitive skin?

Acetyl hexapeptide-3 and protease should be kept apart in your routine because the protease can degrade the peptide bonds and render the active ingredient inactive. Lovi rates this combination as having average compatibility for all skin types.

## Research on acetyl hexapeptide-3 and protease

- [Preparation and functional evaluation of collagen oligopeptide-rich hydrolysate from fish skin with the serine collagenolytic protease from Pseudoalteromonas sp. SM9913](https://pubmed.ncbi.nlm.nih.gov/29146927/) Protease · Scientific Reports, 2017
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-3 · Annals of Dermatology, 2019
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-3 · Journal of Cosmetic and Laser Therapy, 2013

## Other combinations

- Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/adapalene-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and granactive retinoid](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid)
- Keep them apart: [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate)
- Keep them apart: [Pro-retinol and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/pro-retinol-and-acetyl-hexapeptide-3)
- Keep them apart: [Retinal and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/retinal-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and retinoid blend](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-retinoid-blend)
- Depends on the strength: [Retinol and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/retinol-and-acetyl-hexapeptide-3)
- Keep them apart: [Tretinoin and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/tretinoin-and-acetyl-hexapeptide-3)
- Keep them apart: [Vitamin A and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/vitamin-a-and-acetyl-hexapeptide-3)
- Work well together: [Liposome and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/liposome-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and microcapsule](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-microcapsule)
- Depends on the strength: [Vitamin C and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/vitamin-c-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and betaine](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-betaine)
- Work well together: [Glycerin and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/glycerin-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and hyaluronic acid](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/niacinamide-and-acetyl-hexapeptide-3)
- Work well together: [Panthenol and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/panthenol-and-acetyl-hexapeptide-3)
- Work well together: [Bakuchiol and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/bakuchiol-and-acetyl-hexapeptide-3)
- Work well together: [Arginine and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/arginine-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and GABA](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-gaba)
- Work well together: [Silk amino acids and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3)
- Work well together: [Taurine and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/taurine-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and theanine](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/aha-blend-glycolic-and-citric-acids-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and citric acid](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-citric-acid)
- Keep them apart: [Glycolic acid and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/glycolic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Lactic acid and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/lactic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-mandelic-acid)
- Work well together: [Coenzyme Q10 and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/coenzyme-q10-and-acetyl-hexapeptide-3)
- Work well together: [Green tea and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/green-tea-and-acetyl-hexapeptide-3)
- Work well together: [Vitamin E and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/vitamin-e-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and beta-sitosterol](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/ceramide-building-complex-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and cholesterol](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-cholesterol)
- Work well together: [Acetyl hexapeptide-3 and phytosphingosine](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-phytosphingosine)
- Work well together: [Acetyl hexapeptide-3 and phytosterol](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-phytosterol)
- Work well together: [Acetyl hexapeptide-3 and squalene](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-squalene)
- Work well together: [Acetyl hexapeptide-3 and tri-ceramide complex](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/salicylic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and baking soda](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-baking-soda)
- Keep them apart: [Acetyl hexapeptide-3 and bleach](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-bleach)
- Keep them apart: [Acetyl hexapeptide-3 and potassium hydroxide](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide)
- Keep them apart: [Acetyl hexapeptide-3 and behenyl alcohol](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-behenyl-alcohol)
- Keep them apart: [Acetyl hexapeptide-3 and isopropyl alcohol](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-isopropyl-alcohol)
- Keep them apart: [Acetyl hexapeptide-3 and polyvinyl alcohol](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-polyvinyl-alcohol)
- Keep them apart: [Copper and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/copper-and-acetyl-hexapeptide-3)
- Keep them apart: [Magnesium and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/magnesium-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and zinc](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-zinc)
- Keep them apart: [Acetyl hexapeptide-3 and zinc sulfate](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/benzoyl-peroxide-and-acetyl-hexapeptide-3)
- Keep them apart: [Azelaic acid and acetyl hexapeptide-3](https://lovi.care/skincare/au/ingredients/azelaic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and superoxide dismutase](https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase)
- Keep them apart: [Bio-placenta peptides and protease](https://lovi.care/skincare/au/ingredients/bio-placenta-peptides-and-protease)
- Keep them apart: [Collagen peptide and protease](https://lovi.care/skincare/au/ingredients/collagen-peptide-and-protease)
- Keep them apart: [Copper peptide and protease](https://lovi.care/skincare/au/ingredients/copper-peptide-and-protease)
- Keep them apart: [Hexapeptide and protease](https://lovi.care/skincare/au/ingredients/hexapeptide-and-protease)
- Keep them apart: [Hexapeptide-9 and protease](https://lovi.care/skincare/au/ingredients/hexapeptide-9-and-protease)
- Keep them apart: [Protease and palmitoyl pentapeptide-4](https://lovi.care/skincare/au/ingredients/protease-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Protease and palmitoyl tripeptide-1](https://lovi.care/skincare/au/ingredients/protease-and-palmitoyl-tripeptide-1)
- Keep them apart: [Peptide-rich plasma and protease](https://lovi.care/skincare/au/ingredients/peptide-rich-plasma-and-protease)
- Keep them apart: [Protease and triple peptide blend](https://lovi.care/skincare/au/ingredients/protease-and-triple-peptide-blend)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-protease
- United Kingdom: https://lovi.care/skincare/uk/ingredients/acetyl-hexapeptide-3-and-protease
- Ireland: https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-protease
- Germany: https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-protease
- France: https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-protease
- Italy: https://lovi.care/skincare/it/ingredients/acetyl-hexapeptide-3-and-protease
- Netherlands: https://lovi.care/skincare/nl/ingredients/acetyl-hexapeptide-3-and-protease
- Spain: https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-protease
- Canada: https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-protease
- Australia: https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-protease (this page)
- Singapore: https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-protease
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-protease
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/acetyl-hexapeptide-3-and-protease