Sesderma vs NIVEA MEN

Questions and answers

Research behind their key ingredients

• Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin

  Retinol · The Journal of Investigative Dermatology, 2000

• The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer

  Niacinamide · The British Journal of Dermatology, 2002

• Topical use of dexpanthenol in skin disorders

  Panthenol · American Journal of Clinical Dermatology, 2002

• Improvement of naturally aged skin with vitamin A (retinol)

  Retinol · Archives of Dermatology, 2007

• Nicotinic acid/niacinamide and the skin

  Niacin · Journal of Cosmetic Dermatology, 2004

• Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo

  Retinol · International Journal of Cosmetic Science, 2017

• Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing

  Retinol · The British Journal of Dermatology, 2019

• Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo

  Chamomilla recutita flower extract matricaria flower extract, Chamomilla recutita flower extract · International Journal of Molecular Medicine, 2016

• Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris

  Azelaic acid · Pharmaceutics, 2021

• A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin

  Niacin · Experimental Dermatology, 2007

• The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study

  Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017

• A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora

  Panthenol · The Journal of Dermatological Treatment, 2017

• High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin

  Witch hazel leaf extract bark · Phytochemistry, 2001

• Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris

  Azelaic acid · Dermatology and Therapy, 2024

• Influence of vitamin E acetate on stratum corneum hydration

  Tocopheryl acetate, Tocopheryl acetate vitamin e · Arzneimittel-Forschung, 1998

• Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study

  Panthenol · Journal of Cosmetic Dermatology, 2025

• Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy

  Tocopheryl acetate · Scientific Reports, 2025

• Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum

  Caprylic capric triglyceride · Life, 2023

• Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial

  Tocopheryl acetate, Tocopheryl acetate vitamin e · Contemporary Clinical Trials Communications, 2021

• The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study

  Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024

Behind this comparison

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.