Final report on the safety assessment of BHT(1)
Butylated hydroxytoluene 路 International Journal of Toxicology, 2002Topical ascorbic acid on photoaged skin. Clinical, topographical and ultrastructural evaluation: double-blind study vs. placebo
Sodium ascorbyl phosphate ascorbic acid, Ascorbyl palmitate ascorbic acid 路 Experimental Dermatology, 2003Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial
Ascorbic acid, Tocopherol 路 Journal of Cosmetic Dermatology, 2020Effects of menthol and cold on histamine-induced itch and skin reactions in man
Peppermint leaf extract 路 Neuroscience Letters, 1995Anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris
Phytosphingosine 路 International Journal of Cosmetic Science, 2007Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing
Bakuchiol 路 The British Journal of Dermatology, 2019Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo
Sodium ascorbyl phosphate ascorbic acid 路 Journal of Periodontology, 2009Skin penetration and stabilization of formulations containing microfine titanium dioxide as physical UV filter
Titanium dioxide 路 International Journal of Cosmetic Science, 2000The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction
Allantoin 路 Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations
Aloe barbadensis leaf juice powder 路 Clinical Pharmacology, 2018Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin
Ceramides 路 Scientific Reports, 2022Vitamin C mesotherapy versus topical application for gingival hyperpigmentation: a clinical and histopathological study
Ascorbic acid 路 Clinical Oral Investigations, 2021Clinical Assessment of New Topical Cream Containing Two Essential Oils Combined with Tretinoin in the Treatment of Acne
Tretinoin 路 Clinical, Cosmetic and Investigational Dermatology, 2020Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin
Ceramide np 路 International Journal of Dermatology, 2008Effects of Locally Applied Glycerol and Xylitol on the Hydration, Barrier Function and Morphological Parameters of the Skin
Xylitol, Xylitylglucoside 路 Acta Dermato-venereologica, 2017Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation
Ascorbic acid 路 Journal of Cosmetic Dermatology, 2020Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls
Camellia sinensis leaf extract 路 Experimental Dermatology, 2009Anti-inflammatory activities of colloidal oatmeal (Avena sativa) contribute to the effectiveness of oats in treatment of itch associated with dry, irritated skin
Avena sativa kernel extract oat kernel extract 路 Journal of Drugs in Dermatology, 2015The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study
Glycerin 路 Clinical, Cosmetic and Investigational Dermatology, 2017Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy
Niacinamide, Gentlebright complex 路 Journal of Cosmetic Dermatology, 2021Niacinamide mitigates SASP-related inflammation induced by environmental stressors in human epidermal keratinocytes and skin
Gentlebright complex 路 International Journal of Cosmetic Science, 2020The human stratum corneum layer: an effective barrier against dermal uptake of different forms of topically applied micronised titanium dioxide
Titanium dioxide 路 Skin Pharmacology and Applied Skin Physiology, 2001Anti-Aging Effects of Leontopodium alpinum (Edelweiss) Callus Culture Extract Through Transcriptome Profiling
Leontopodium alpinum extract 路 Genes, 2020Two superior antioxidants: Ferulic acid and ascorbic acid in reducing signs of photoaging-A split-face comparative study
Sodium ascorbyl phosphate ascorbic acid 路 Dermatologic Therapy, 2022A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora
Panthenol, Panthenol vitamin b5 路 The Journal of Dermatological Treatment, 2017Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging
Niacinamide 路 Scientific Reports, 2024A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population
Salicylic acid 路 BioMed Research International, 2020Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation
Tocopheryl acetate vitamin e, Tocopheryl acetate vitamin e acetate 路 Urologia Internationalis, 2019Ascorbic Acid Treatments as Effective and Safe Anti-Aging Therapies for Sensitive Skin
Ascorbyl palmitate ascorbic acid 路 Antioxidants, 2024Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration
Adenosine 路 International Journal of Cosmetic Science, 2018Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris
Mandelic acid 路 Journal of Cosmetic Dermatology, 2020Another Reason for Using Caffeine in Dermocosmetics: Sunscreen Adjuvant
Caffeine 路 Frontiers in Physiology, 2019Structural characterization and in vivo evaluation of retinyl palmitate in non-ionic lamellar liquid crystalline system
Retinyl palmitate 路 Colloids and Surfaces. B, Biointerfaces, 2011A Dunaliella salina Extract Counteracts Skin Aging under Intense Solar Irradiation Thanks to Its Antiglycation and Anti-Inflammatory Properties
Dunaliella salina extract 路 Marine Drugs, 2022Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial
Panthenol vitamin b5, Panthenol, Allantoin 路 Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study
Pha polyhydroxy acid 路 Clinical, Cosmetic and Investigational Dermatology, 2019Efficacy assessments of tretinoin-loaded nano lipid carriers in acne vulgaris: a double blind, split-face randomized clinical study
Tretinoin 路 Archives of Dermatological Research, 2022Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials
Tretinoin 路 International Journal of Women's Dermatology, 2022In vivo anti-ageing activity of cream containing niosomes loaded with purple glutinous rice (Oryza sativa Linn.) extract
Rice extract lees extract 路 International Journal of Cosmetic Science, 2020A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne
Pha polyhydroxy acid 路 The Australasian Journal of Dermatology, 1992Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study
Salicylic acid 路 Journal of Cosmetic Dermatology, 2024Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach
Zinc oxide 路 Journal of Controlled Release, 2025Fatty acids based 伪-Tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects
Vitamin e 路 Journal of Cosmetic Dermatology, 2020A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid
Ceramide np 路 Skin Pharmacology and Physiology, 2022Comparison of clinical efficacies of sodium ascorbyl phosphate, retinol and their combination in acne treatment
Sodium ascorbyl phosphate 路 International Journal of Cosmetic Science, 2009A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide
Salicylic acid 路 Journal of Drugs in Dermatology, 2023Colloidal Oatmeal <em>(Avena Sativa)</em> Improves Skin Barrier Through Multi-Therapy Activity
Avena sativa kernel extract oat kernel extract 路 Journal of Drugs in Dermatology, 2016Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs
Vitamin e 路 Journal of Cosmetic Dermatology, 2022Nanogel Containing Gamma-Oryzanol-Loaded Nanostructured Lipid Carriers and TiO2/MBBT: A Synergistic Nanotechnological Approach of Potent Natural Antioxidants and Nanosized UV Filters for Skin Protection
Xanthan gum 路 Pharmaceuticals, 2023Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial
Hydrolyzed hyaluronic acid 路 Dermatologic Therapy, 2022Subclinical, non-erythematous irritation with an open assay model (washing): sodium lauryl sulfate (SLS) versus sodium laureth sulfate (SLES)
Sodium laureth sulfate 路 Food and Chemical Toxicology, 2001In Vitro and Clinical Safety Assessment of the Multiple W/O/W Emulsion Based on the Active Ingredients from Rosmarinus officinalis L., Avena sativa L. and Linum usitatissimum L
Avena sativa kernel extract oat kernel extract 路 Pharmaceutics, 2021Whitening effect of alpha-bisabolol in Asian women subjects
Bisabolol 路 International Journal of Cosmetic Science, 2010Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris
Citric acid 路 Journal of Cosmetic Dermatology, 2021Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers
Sodium ascorbyl phosphate 路 Drug Research, 2017The impacts of sodium lauroyl sarcosinate in facial cleanser on facial skin microbiome and lipidome
Sodium lauroyl sarcosinate 路 Journal of Cosmetic Dermatology, 2024Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement
Adenosine 路 Journal of Cosmetic Dermatology, 2019Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration
Betaine 路 Molecules, 2024Supramolecular collagen nanoparticles for anti-wrinkle, skin whitening, and moisturizing effects
Palmitoyl tripeptide-5 路 Colloids and Surfaces. B, Biointerfaces, 2025Topical application of highly concentrated water-in-oil emulsions: Physiological skin parameters and skin penetration in vivo - A pilot study
Isopropyl myristate 路 International Journal of Pharmaceutics, 2019Why is sodium cocoyl isethionate (SCI) mild to the skin barrier? - An in vitro investigation based on the relative sizes of the SCI micelles and the skin aqueous pores
Sodium cocoyl isethionate 路 Journal of Cosmetic Science, 2007Influence of vitamin E acetate on stratum corneum hydration
Tocopheryl acetate vitamin e, Tocopheryl acetate 路 Arzneimittel-Forschung, 1998The use of different concentrations of betaine as a reducing irritation agent in soaps monitored visually and non-invasively
Betaine 路 Skin Research and Technology, 2003Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid
Pha polyhydroxy acid 路 Journal of Cosmetic Dermatology, 2010Clinical efficacy and safety of nano-microneedle-assisted phenylethyl resorcinol for the treatment of infraorbital dark circles
Phenylethyl resorcinol 路 Journal of Cosmetic Dermatology, 2021Comparative physicochemical stability and clinical anti-wrinkle efficacy of transdermal emulgel preparations of 5% sodium ascorbyl phosphate and or ascorbic acid on human volunteers
Sodium ascorbyl phosphate 路 Journal of Cosmetic Dermatology, 2021Topical prevention from high energy visible light-induced pigmentation by 2-mercaptonicotinoyl glycine, but not by ascorbic acid antioxidant: 2 randomized controlled trials
Ascorbyl palmitate ascorbic acid 路 Frontiers in Pharmacology, 2025Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence
Zinc oxide 路 Biomedicines, 2025Modulation of lipid fluidity likely contributes to the fructose/xylitol-induced acceleration of epidermal permeability barrier recovery
Xylitylglucoside 路 Archives of Dermatological Research, 2019Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study
Panthenol, Panthenol vitamin b5 路 Journal of Cosmetic Dermatology, 2025Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol
Caprylyl glycol 路 Cutaneous and Ocular Toxicology, 2009Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study
Hydrolyzed hyaluronic acid 路 Aesthetic Plastic Surgery, 2026Modulation of skin pigmentation by the tetrapeptide PKEK: in vitro and in vivo evidence for skin whitening effects
Sodium ascorbyl phosphate 路 Experimental Dermatology, 2012Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin
Vitamin e 路 Journal of Cosmetic Dermatology, 2024The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites
Retinyl palmitate 路 Journal of Cosmetic Dermatology, 2013Modulating effects of oatmeal extracts in the sodium lauryl sulfate skin irritancy model
Avena sativa kernel extract oat kernel extract 路 Skin Pharmacology and Applied Skin Physiology, 2002Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays
Xylitylglucoside 路 Molecules, 2021Nanostructured Lipid Carrier Based Gel Containing 伪-Tocopherol and 伪-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy
Tocopheryl acetate vitamin e, Tocopheryl acetate vitamin e acetate, Tocopheryl acetate 路 Scientific Reports, 2025Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery
Hydrolyzed hyaluronic acid 路 Colloids and Surfaces. B, Biointerfaces, 2022Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence
Adenosine 路 International Journal of Molecular Sciences, 2026Evaulation of irritation potential of surfactant mixtures
Sodium laureth sulfate 路 International Journal of Cosmetic Science, 1999Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial
Tocopheryl acetate vitamin e, Tocopheryl acetate 路 Contemporary Clinical Trials Communications, 2021Facial disbiosis and UV filters
Octocrylene 路 Archives of Dermatological Research, 2024A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen
Pha polyhydroxy acid 路 Cutis, 2004A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN+) Product for Male Facial Skin: Effects on Skin Appearance and Properties
Bakuchiol 路 Skin Research and Technology, 2026Synergistic combination: Developing a natural carrier-free assembled gel through hydrogen bond reconstruction strategy for efficient skin photo-damage restoration
Sodium pca 路 Biomaterials Advances, 2026Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial
Dipotassium glycyrrhizate 路 Journal of Cosmetic Dermatology, 2026Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population
Bakuchiol 路 Health Science Reports, 2025Impact of dermal emulsions containing diacyl phospholipids, mono acyl phospholipids, sodium lauryl ether sulfate and polysorbate 80 in combination with UVA irradiation on human skin physiology in vivo: A pilot study
Sodium laureth sulfate 路 International Journal of Pharmaceutics, 2026
