# ZO Skin Health Growth Factor Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ae/p/zo-skin-health/growth-factor-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [ZO Skin Health](https://lovi.care/skincare/ae/brands/zo-skin-health)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your normal skin as Buddleja Davidii Meristem Cell Culture and Dipeptide Diaminobutyroyl Benzylamide Diacetate provide antioxidant activity and support collagen synthesis, addressing your wrinkles and fine lines.
- The inclusion of Panthenyl Triacetate and Ethyl Linoleate further enhances skin hydration and barrier function, complementing the primary anti-aging benefits.
- The product is safe for your skin, with no harsh ingredients or irritants present.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/zo-skin-health/growth-factor-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ae/p/zo-skin-health/growth-factor-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ae/p/zo-skin-health/growth-factor-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ae/p/zo-skin-health/growth-factor-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ae/p/zo-skin-health/growth-factor-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/ae/p/zo-skin-health/growth-factor-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ae/p/zo-skin-health/growth-factor-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/zo-skin-health/growth-factor-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/zo-skin-health/growth-factor-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Dipeptide Diaminobutyroyl Benzylamide Diacetate, Adenosine Triphosphate, Beta-Glucan, Angelica Polymorpha Sinensis Root Extract, Hydrolyzed Sericin

## What the research says

- A novel anti-aging serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate, gluconolactone, niacinamide, and laminaria extract significantly increased anti-aging biomarkers and improved static and dynamic wrinkles as well as skin quality in clinical studies. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/))
- Verbascoside- and teupolioside-containing extracts significantly accelerated wound healing, exhibited anti-inflammatory action, inhibited reactive oxygen species release, and suppressed chemokine and growth factor expression in cultured human keratinocytes compared to pro-inflammatory controls. ([Cellular and Molecular Biology, 2007](https://pubmed.ncbi.nlm.nih.gov/17543237/))
- Treatment with a bioactive complex of Panthenyl triacetate and Ethyl linoleate at 3% protected human skin biopsies against UV-induced protein oxidation by 72% with pre-treatment and 78% with post-treatment, while also stimulating the expression of protein repairing enzymes compared to UV-irradiated controls. ([International Journal of Cosmetic Science, 2010](https://pubmed.ncbi.nlm.nih.gov/19818086/))
- Panthenyl triacetate (PTA) demonstrated skin de-acetylation into panthenol, stimulated energetic and synthesis metabolic pathways, and achieved a statistically significant improvement in wound healing after 72 hours compared to saline treatment in human volunteers, outperforming panthenol in long-lasting wound healing action. ([Journal of Cosmetic Science, 2012](https://pubmed.ncbi.nlm.nih.gov/22487447/))
- A bacterial nanocellulose wound dressing incorporating polyhexamethylene biguanide and sericin showed no skin irritation in healthy volunteers and significantly promoted wound healing with lower wound size and higher collagen formation in full-thickness rat wounds compared to controls. ([Archives of Dermatological Research, 2016](https://pubmed.ncbi.nlm.nih.gov/26796543/))
- The application of a vitamin B12 and adenosine triphosphate complex improved skin radiance, elasticity, and texture in human participants. ([Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/39194754/))
- Direct delivery of intracellular adenosine triphosphate using ATP-encapsulated fusogenic small unilamellar lipid vesicles accelerated wound healing, improved granular tissue development, re-epithelialization, and increased vascular endothelial growth factor expression compared to lipid vesicles alone in adult nude mice. ([American Journal of Surgery, 2007](https://pubmed.ncbi.nlm.nih.gov/17236849/))
- A self-powered chloroplast-driven nanophotosystem consisting of Chlorella-derived nanothylakoid units and hyaluronic acid microneedles increased mitochondrial biogenesis, adenosine triphosphate generation, and NAD(P)H pools in senescent fibroblasts, leading to increased collagen synthesis and alleviated skin photoaging. ([Journal of Nanobiotechnology, 2026](https://pubmed.ncbi.nlm.nih.gov/42144642/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Treatment with topical formulations containing beta-glucan combined with nanofractional radiofrequency plus magnetic nanofractional radiofrequency showed the best efficacy and was tolerable and effective in Chinese women with abdominal stretch marks compared to control groups. ([Dermatology and Therapy, 2023](https://pubmed.ncbi.nlm.nih.gov/37171578/))
- Topical beta-glucan mildly improved striae gravidarum, 1565-nm non-ablative fractional laser showed better results than topical beta-glucan, and the combined strategy further improved striae gravidarum atrophy compared to single treatment. ([The Journal of Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35570397/))
- Angelica sinensis essential oil at 5%-10% demonstrated significant anti-acne effects comparable to adapalene gel with reduced side effects in mice by suppressing Cutibacterium acnes and downregulating IL-1β. ([Journal of Ethnopharmacology, 2026](https://pubmed.ncbi.nlm.nih.gov/41482092/))
- An Angelica sinensis extract containing 1% ligustilide demonstrated anti-inflammatory, antioxidant, anti-senescence, matrix-supportive, and antimicrobial effects in human keratinocytes and dermal fibroblasts. ([Frontiers in Pharmacology, 2026](https://pubmed.ncbi.nlm.nih.gov/41948733/))
- Topical application of Angelica sinensis extract induced noticeable hair regrowth, restored hair shaft lengths and follicle size, and decreased apoptotic cells in C57BL/6 mice. ([The American Journal of Chinese Medicine, 2014](https://pubmed.ncbi.nlm.nih.gov/25004889/))
- Bacterial cellulose wound dressing containing silk sericin and PHMB improved wound quality and reduced pain compared to Bactigras in patients with split-thickness skin graft donor-site wounds. ([Archives of Dermatological Research, 2018](https://pubmed.ncbi.nlm.nih.gov/30302557/))
- Topical application of sericin gels increased skin intrinsic moisturization, hydroxyproline content, and epidermal hydration while decreasing transepidermal water loss and skin impedance in healthy human volunteers. ([Journal of Cosmetic Dermatology, 2005](https://pubmed.ncbi.nlm.nih.gov/17168872/))
- Silk sericin-releasing bacterial nanocellulose gel demonstrated improved mechanical properties, controlled sericin release, non-cytotoxicity on L929 and HaCaT cells, and non-irritancy in subcutaneous tissue compared to a commercially available paper mask. ([BMC Biotechnology, 2014](https://pubmed.ncbi.nlm.nih.gov/25487808/))

## What reviewers say

Based on a very large amount of data, this product is highly regarded by users with aging, dry, and sensitive skin for its hydrating and plumping effects, visibly reducing fine lines. The lightweight gel formula is frequently praised for restoring the skin's moisture barrier and improving texture. However, some users with acne-prone skin report breakouts, and the high price is a common concern.

- Liked: Lightweight gel (mostly mentioned)
- Liked: Hydrating, plumping (often mentioned)
- Disliked: Very expensive (often mentioned)
- Liked: Gentle, soothing (sometimes noted)
- Liked: Reduces lines (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Causes breakouts (rarely noted)
- Disliked: Faulty pump (rarely noted)
- Disliked: Pills under makeup (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Growth Factor Serum a great fit for mature skin?

ZO Skin Health Growth Factor Serum is a great fit for mature skin because Buddleja Davidii Meristem Cell Culture and Dipeptide Diaminobutyroyl Benzylamide Diacetate help protect against damage and support collagen production to smooth out wrinkles and fine lines. Panthenyl Triacetate and Ethyl Linoleate further boost skin hydration and strengthen the moisture barrier to keep skin soft and healthy.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/), [International Journal of Cosmetic Science, 2010](https://pubmed.ncbi.nlm.nih.gov/19818086/)

### Which ingredients make this serum a good fit for mature skin?

Buddleja Davidii Meristem Cell Culture and Dipeptide Diaminobutyroyl Benzylamide Diacetate make this serum a great fit because they provide antioxidant activity and support collagen synthesis to help smooth wrinkles and fine lines. Panthenyl Triacetate and Ethyl Linoleate further enhance skin hydration and barrier function.
Sources: [International Journal of Cosmetic Science, 2010](https://pubmed.ncbi.nlm.nih.gov/19818086/), [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/)

### What does Dipeptide Diaminobutyroyl Benzylamide Diacetate do for mature skin?

Dipeptide diaminobutyroyl benzylamide diacetate helps smooth the look of wrinkles and improves overall skin quality on mature skin. It works to boost anti-aging markers, making the skin look firmer and more youthful.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/)

### What does Adenosine Triphosphate do for mature skin?

Adenosine Triphosphate helps mature skin by improving radiance, elasticity, and texture, and it may support collagen synthesis to keep skin looking firm and youthful. These benefits are especially helpful for older skin, which often needs an energy boost to maintain its natural renewal and smooth feel.
Sources: [Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/39194754/), [Journal of Nanobiotechnology, 2026](https://pubmed.ncbi.nlm.nih.gov/42144642/)

### Where does this serum go in a skincare routine for mature skin?

This treatment serum goes in the evening routine after cleansing and toning, and before your moisturizer. Putting treatments in the evening provides simplicity and extra safety around sun exposure.

### Can I use it with retinol, and in what order?

You can use this treatment alongside retinol by applying the retinol first and following with this serum, or by using retinol in the evening and this treatment in the morning. This routine helps smooth fine lines while minimizing potential irritation.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/)

### How often should I use it?

Use this treatment in your evening routine, applying it after your cleansing toner and before your moisturizer. It is gentle enough for daily evening use to help smooth fine lines and keep your mature skin looking firm.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41668671/), [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause breakouts or clog pores for mature skin because it contains no harsh ingredients or heavy irritants. Reviewers occasionally report breakouts, but this happens rarely.
Sources: [Archives of Dermatological Research, 2016](https://pubmed.ncbi.nlm.nih.gov/26796543/)

### Is it fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum). Oleyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/ae/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — AED 347.75 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — AED 715.99 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/ae/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — AED 89.30 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ae/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — AED 84.53 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ae/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — AED 65.43 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/ae/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — AED 493.00 at Amazon

## Where to buy

- Amazon.ae: AED 925.00 (https://www.amazon.ae/dp/B0GVNQD68B?tag=lovi00-21&linkCode=osi&th=1&psc=1)
Prices checked 2 Nov 2026.

## Ingredients

Water, Cyclopentasiloxane, Dipropylene Glycol, Propylene Glycol, Dimethicone, Glycerin, Dimethicone Crosspolymer, Dimethicone Peg-10 15 Crosspolymer, Peg-12 Dimethicone Crosspolymer, Butylene Glycol, Dimethicone Vinyl Dimethicone Crosspolymer, Sodium Phosphate, Panthenyl Triacetate, Magnesium Sulfate, Hydrolyzed Sericin, Ethyl Linoleate, Buddleja Davidii Meristem Cell Culture, Angelica Polymorpha Sinensis Root Extract, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Lactobacillus Panax Ginseng Root Extract Ferment Filtrate, Disodium Acetyl Glucosamine Phosphate, Acetyl Tyrosine, Dimethiconol, Oleyl Alcohol, Proline, Parfum, Tocopherol, Beta-Glucan, Adenosine Triphosphate, Hydrolyzed Protein, Sodium Chloride, Xanthan Gum, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/zo-skin-health/growth-factor-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/zo-skin-health/growth-factor-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/zo-skin-health/growth-factor-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/zo-skin-health/growth-factor-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/zo-skin-health/growth-factor-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/zo-skin-health/growth-factor-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/zo-skin-health/growth-factor-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/zo-skin-health/growth-factor-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/zo-skin-health/growth-factor-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/zo-skin-health/growth-factor-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/zo-skin-health/growth-factor-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/zo-skin-health/growth-factor-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/zo-skin-health/growth-factor-serum/for/mature-skin (this page)