# Sesderma Azelac RU Serum for sensitive skin **Lovi Fit: Average fit for sensitive skin.** Normal Skin Fit: High · Effectiveness: Average · Safety: High. Page: https://lovi.care/skincare/ae/p/sesderma/azelac-ru-serum/for/sensitive-skin The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates. Brand: [Sesderma](https://lovi.care/skincare/ae/brands/sesderma) Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums) This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app. Works for sensitive skin; other serums fit it better. ## Why this fit - Offers moderate skin brightening for your normal skin due to the presence of 4-butylresorcinol and azelaic acid, which inhibit melanin production and offer anti-inflammatory benefits. - While the product provides general hydration and soothing effects, it lacks specialized ingredients to effectively target your redness and irritation concerns. - The formulation is safe for your sensitive skin, as it avoids harsh ingredients and potential irritants. ## Fit by skin type - [Oily skin](https://lovi.care/skincare/ae/p/sesderma/azelac-ru-serum/for/oily-skin): Average - [Dry skin](https://lovi.care/skincare/ae/p/sesderma/azelac-ru-serum/for/dry-skin): Low - [Combination skin](https://lovi.care/skincare/ae/p/sesderma/azelac-ru-serum/for/combination-skin): High - [Sensitive skin](https://lovi.care/skincare/ae/p/sesderma/azelac-ru-serum/for/sensitive-skin): Average (this page) - [Acne-prone skin](https://lovi.care/skincare/ae/p/sesderma/azelac-ru-serum/for/acne-prone-skin): High - [Skin with dark spots](https://lovi.care/skincare/ae/p/sesderma/azelac-ru-serum/for/dark-spots): High - [Mature skin](https://lovi.care/skincare/ae/p/sesderma/azelac-ru-serum/for/mature-skin): Average - [Dry sensitive skin](https://lovi.care/skincare/ae/p/sesderma/azelac-ru-serum/for/dry-sensitive-skin): Low - [Oily acne-prone skin](https://lovi.care/skincare/ae/p/sesderma/azelac-ru-serum/for/oily-acne-prone-skin): Average ## Key ingredients Liposomal Azelaic Acid, 4-Butylresorcinol, Tranexamic Acid, Niacinamide, Retinol ## What the research says - Azelaic acid nanocrystal hydrogel 10% achieved a higher success rate and greater lesion reduction than azelaic acid cream 20% in patients with mild to moderate facial acne. ([Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)) - Application of 15% azelaic acid gel significantly reduced post-inflammatory erythema and hyperpigmentation, decreased hemoglobin and melanin content, improved quality of life, and contributed to acne improvement in patients with mild to moderate acne compared to placebo. ([Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/)) - Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2023](https://pubmed.ncbi.nlm.nih.gov/36729399/)) - The 4-n-butylresorcinol dissolving microneedle patch demonstrated safety and was more than two times more effective than the control patch in skin depigmentation among 45 subjects over 8 weeks. ([Journal of Cosmetic Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/26341915/)) - 4-n-butylresorcinol inhibits human tyrosinase and melanin production more potently than hydroquinone, arbutin, and kojic acid, and visibly reduces age spots within 8 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2013](https://pubmed.ncbi.nlm.nih.gov/23205541/)) - Combined application of dissolving microneedle patches on serum-treated skin successfully delivered more 4-n-butylresorcinol and showed higher efficacy in reducing patients' melanin index and hyperpigmented regions compared to traditional DMN-only and serum-only applications. ([Molecular Pharmaceutics, 2017](https://pubmed.ncbi.nlm.nih.gov/28447799/)) - Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)) - Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/)) - Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/)) - Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)) - Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)) - Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/)) ## Why other serums fit sensitive skin better - Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/)) ## What reviewers say Users report this serum effectively brightens the complexion and fades post-acne marks and sunspots, often showing visible results within a few weeks. It is praised for its lightweight texture and ability to control mild acne, though some users note it requires patience for older, deeper pigmentation and can be slightly drying. - Liked: Fades dark spots (mostly mentioned) - Liked: Brightens skin tone (often mentioned) - Liked: Lightweight texture (often mentioned) - Disliked: High price (often mentioned) - Liked: Controls acne (sometimes noted) - Liked: Gentle on skin (sometimes noted) - Disliked: Slow results (sometimes noted) - Disliked: Drying effect (rarely noted) - Disliked: Sticky finish (rarely noted) ## How to apply - Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy. - Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results. - Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in. - Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm. - Always do a patch test before your first use and avoid getting the serum too close to your eyes . - Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4 ## Questions and answers ### How well does Sesderma Azelac RU work for sensitive skin? Sesderma Azelac RU Serum is an average fit for sensitive skin because it provides general hydration and soothing effects while being safe for sensitive skin, but it lacks specialized ingredients to effectively target redness and irritation concerns. Treatment products of this type need effective ingredients that provide excellent skincare benefits for redness and irritation, along with potent antioxidants, hydrating components, and skin-repairing ingredients to truly suit sensitive skin. ### Which ingredients make this serum a good fit for sensitive skin? This serum is a safe fit for sensitive skin because it avoids harsh ingredients and potential irritants. To best care for sensitive skin, a treatment of this type needs soothing ingredients like niacinamide and snail secretion filtrate to calm redness and irritation. ### What does Azelaic Acid do for sensitive skin? Azelaic acid helps calm sensitive, easily irritated skin by soothing redness and reducing swelling. It works gently to quiet inflammation without causing extra irritation, making it a safe choice for reactive skin types. Sources: [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20545756/), [Archives of Dermatological Research, 1991](https://pubmed.ncbi.nlm.nih.gov/1867478/) ### What does 4-Butylresorcinol do for sensitive skin? Using 4-butylresorcinol on sensitive skin requires caution because it may cause irritation if not used carefully. This ingredient is potent for fading dark spots, but sensitive skin needs a gentle formula with soothing ingredients and a low concentration to avoid redness. Sources: [Pharmaceuticals, 2023](https://pubmed.ncbi.nlm.nih.gov/38256889/) ### Where does it go in a skincare routine for sensitive skin? This treatment goes in the evening routine. Treatments with active ingredients are placed at night for simplicity and extra safety around sun exposure. ### Can I use this serum with AHA, and in what order? You can use this serum with AHA, but to keep your sensitive skin calm, apply the AHA first and follow with this treatment once your skin has adjusted. This serum is safe for your sensitive skin because it avoids harsh ingredients and potential irritants, but a product of this type needs soothing plant extracts and extra hydration to properly target redness and irritation. ### How often should I use it? Use this treatment in the evening as part of your nighttime routine, starting once a week to see how your skin feels. While the formulation is generally safe and avoids harsh irritants, a sensitive skin type needs gentle soothing ingredients and extra hydration to properly manage redness and irritation. ### Can this serum clog pores, cause breakouts or purging for sensitive skin? Sesderma Azelac RU Serum is unlikely to clog pores or cause breakouts for sensitive skin because its formula avoids heavy, pore-clogging ingredients. However, because it contains retinol, you may experience mild initial purging or peeling as your skin adjusts. ### Is it fragrance-free and alcohol-free? It contains fragrance (parfum) and drying alcohol (alcohol). ## Alternatives for sensitive skin - [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/ae/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — AED 347.75 at Amazon - [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — AED 715.99 at Amazon - [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/ae/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — AED 89.30 at Amazon ## Pairs well with - Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ae/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — AED 84.53 at Amazon - Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/ae/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — AED 81.41 at Amazon - Moisturizer with Sun Protection: [Bioderma Bioderma Photoderm Mineral SPF 50+](https://lovi.care/skincare/ae/p/bioderma/photoderm-mineral-fluide-spf50/for/sensitive-skin) — Superior fit — AED 65.10 at Amazon ## Where to buy - Amazon.ae: AED 123.63 (https://www.amazon.ae/dp/B00987RKWW?tag=lovi00-21&linkCode=osi&th=1&psc=1) Prices checked 5 Nov 2026. ## Ingredients Water, Propylene Glycol, Alcohol, Peg Ppg-20 6 Dimethicone, Polymethyl Methacrylate, Peg-40 Hydrogenated Castor Oil, 4-Butylresorcinol, Azelaic Acid, Retinol, Ascorbyl Glucoside, Niacin, Undecylenoyl Phenylalanine, Glycyrrhetinic Acid, Diacetyl Boldine, Citronellyl Methylcrotonate, Sodium Oxalate, Parfum, Carbomer, Xanthan Gum, Tocopheryl Acetate, Polysorbate 20, Bht, Ethylhexylglycerin, Sodium Hydroxide, Caprylic Capric Triglyceride, Sodium Chloride, Bha, Hydrochloric Acid ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/p/sesderma/azelac-ru-serum/for/sensitive-skin - United Kingdom: https://lovi.care/skincare/uk/p/sesderma/azelac-ru-serum/for/sensitive-skin - Ireland: https://lovi.care/skincare/ie/p/sesderma/azelac-ru-serum/for/sensitive-skin - Germany: https://lovi.care/skincare/de/p/sesderma/azelac-ru-serum/for/sensitive-skin - France: https://lovi.care/skincare/fr/p/sesderma/azelac-ru-serum/for/sensitive-skin - Italy: https://lovi.care/skincare/it/p/sesderma/azelac-ru-serum/for/sensitive-skin - Netherlands: https://lovi.care/skincare/nl/p/sesderma/azelac-ru-serum/for/sensitive-skin - Spain: https://lovi.care/skincare/es/p/sesderma/azelac-ru-serum/for/sensitive-skin - Canada: https://lovi.care/skincare/ca/p/sesderma/azelac-ru-serum/for/sensitive-skin - Australia: https://lovi.care/skincare/au/p/sesderma/azelac-ru-serum/for/sensitive-skin - Singapore: https://lovi.care/skincare/sg/p/sesderma/azelac-ru-serum/for/sensitive-skin - Saudi Arabia: https://lovi.care/skincare/sa/p/sesderma/azelac-ru-serum/for/sensitive-skin - United Arab Emirates: https://lovi.care/skincare/ae/p/sesderma/azelac-ru-serum/for/sensitive-skin (this page)