# Sesderma Azelac RU Liposomal Serum for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/ae/p/sesderma/azelac-ru-liposomal-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [Sesderma](https://lovi.care/skincare/ae/brands/sesderma)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your combination skin, this serum effectively targets hyperpigmentation and inflammation with azelaic acid and tranexamic acid, while retinol and 4-butylresorcinol work to even skin tone and promote cell turnover. Niacin and glycerin provide soothing benefits, ensuring comfort for your skin type.
- The formulation offers moderate benefits for acne and blemishes by targeting inflammation and cell turnover with azelaic acid and retinol.
- This product is safe for your combination skin, as it contains no harsh ingredients and includes soothing components like niacin and glycerin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/sesderma/azelac-ru-liposomal-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ae/p/sesderma/azelac-ru-liposomal-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ae/p/sesderma/azelac-ru-liposomal-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/ae/p/sesderma/azelac-ru-liposomal-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ae/p/sesderma/azelac-ru-liposomal-serum/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/ae/p/sesderma/azelac-ru-liposomal-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ae/p/sesderma/azelac-ru-liposomal-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/sesderma/azelac-ru-liposomal-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/sesderma/azelac-ru-liposomal-serum/for/oily-acne-prone-skin): High

## Key ingredients

Azelaic Acid, Tranexamic Acid, Retinol, Niacin, 4-Butylresorcinol

## What the research says

- Application of 15% azelaic acid gel significantly reduced post-inflammatory erythema and hyperpigmentation, decreased hemoglobin and melanin content, improved quality of life, and contributed to acne improvement in patients with mild to moderate acne compared to placebo. ([Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/))
- Azelaic acid nanocrystal hydrogel 10% achieved a higher success rate and greater lesion reduction than azelaic acid cream 20% in patients with mild to moderate facial acne. ([Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/))
- Topical myristyl nicotinate increased skin cell NAD, stratum corneum thickness, epidermal thickness, epidermal renewal, minimal erythemal dose, and barrier resistance while reducing transepidermal water loss in subjects with photodamaged skin compared to placebo. ([Experimental Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17518989/))
- Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2023](https://pubmed.ncbi.nlm.nih.gov/36729399/))
- Topical administration of 20% azelaic acid cream and 5% tranexamic acid solution comparably improved acne-related postinflammatory hyperpigmentation in patients with acne vulgaris, while tranexamic acid demonstrated a significantly better safety profile at week 4. ([Journal of Research in Medical Sciences, 2023](https://pubmed.ncbi.nlm.nih.gov/37213446/))
- Azelaic acid 15% gel showed comparable efficacy to adapalene 0.1% gel in reducing lesions, severity, and Dermatology Life Quality Index in women with adult acne, with significantly lower dryness and scaling, and demonstrated superiority during maintenance compared to no further treatment. ([Journal of the European Academy of Dermatology and Venereology, 2015](https://pubmed.ncbi.nlm.nih.gov/25399481/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- The 4-n-butylresorcinol dissolving microneedle patch demonstrated safety and was more than two times more effective than the control patch in skin depigmentation among 45 subjects over 8 weeks. ([Journal of Cosmetic Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/26341915/))
- 4-n-butylresorcinol inhibits human tyrosinase and melanin production more potently than hydroquinone, arbutin, and kojic acid, and visibly reduces age spots within 8 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2013](https://pubmed.ncbi.nlm.nih.gov/23205541/))
- Combined application of dissolving microneedle patches on serum-treated skin successfully delivered more 4-n-butylresorcinol and showed higher efficacy in reducing patients' melanin index and hyperpigmented regions compared to traditional DMN-only and serum-only applications. ([Molecular Pharmaceutics, 2017](https://pubmed.ncbi.nlm.nih.gov/28447799/))

## What reviewers say

Based on limited data, users frequently report this serum effectively brightens the complexion and reduces hyperpigmentation like melasma, sun spots, and acne marks, leading to smoother and more luminous skin. Many appreciate its fast absorption and lightweight feel. Some users with sensitive or dry skin find it can be drying and recommend using a moisturizer.

- Liked: Fast absorption (mostly mentioned)
- Liked: Fades dark spots (often mentioned)
- Liked: Improves texture (often mentioned)
- Liked: Acne control (sometimes noted)
- Disliked: Drying effect (sometimes noted)
- Disliked: High price (rarely noted)
- Disliked: Slow results (rarely noted)
- Disliked: Sticky finish (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Sesderma Azelac RU Serum a great fit for acne-prone skin?

This serum is a great fit for acne-prone skin because it targets blemishes and inflammation using azelaic acid and retinol, while soothing ingredients like niacin keep the skin calm and comfortable.
Sources: [Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/), [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### Which ingredients make this serum a good fit for acne-prone skin?

This serum is a great fit for your acne-prone skin because it contains azelaic acid and retinol, which help target inflammation and promote cell turnover. Niacin and glycerin also provide soothing benefits to help keep your skin comfortable.
Sources: [Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/), [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### What does Azelaic Acid do for acne-prone skin?

Azelaic acid helps clear acne-prone skin by fighting bacteria and calming redness, while also fading dark spots left behind by breakouts. It targets multiple causes of acne at once to keep your skin smooth and even-toned.
Sources: [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26355614/), [Postepy Dermatologii I Alergologii, 2023](https://pubmed.ncbi.nlm.nih.gov/38282869/)

### What does Tranexamic Acid do for acne-prone skin?

Tranexamic acid helps calm red marks left behind by breakouts and reduces inflammatory bumps like pimples on acne-prone skin. It is unlikely to cause irritation and works well to improve uneven skin tone without significant side effects.
Sources: [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35388589/), [Journal of Research in Medical Sciences, 2023](https://pubmed.ncbi.nlm.nih.gov/37213446/)

### Where does this serum go in a skincare routine for acne-prone skin?

This serum goes in your evening routine as a treatment step after cleansing and toning, and before moisturizing. Putting it in the evening helps avoid sun sensitivity from actives like retinol while keeping your skin calm and even.

### Can I use this serum with vitamin C, and in what order?

You can use this serum with vitamin C by applying vitamin C in the morning and this treatment in your evening routine. This separation helps reduce the likelihood of skin irritation from combining strong ingredients like retinol and vitamin C.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [American Family Physician, 2012](https://pubmed.ncbi.nlm.nih.gov/23062156/)

### How often should I use this serum?

This serum is a great fit for your acne-prone skin, helping target inflammation and dark spots in your evening routine. You can start using it once a week and gradually build up frequency as your skin adjusts comfortably.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is a great fit for acne-prone skin because it targets inflammation and helps clear blemishes with azelaic acid and retinol. It is unlikely to cause breakouts, though it may cause mild dryness.
Sources: [Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/), [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (parfum) and drying alcohol (alcohol and alcohol denat).

## Alternatives for acne-prone skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — AED 715.99 at Amazon
- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/ae/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/acne-prone-skin) — Superior fit — AED 365.22 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/ae/p/neogen-dermalogy/real-vitamin-c-serum/for/acne-prone-skin) — Superior fit — AED 89.30 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ae/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — AED 49.95 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/ae/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — AED 49.99 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/ae/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — AED 91.81 at Amazon

## Where to buy

No store in United Arab Emirates has a checked price for this product, so the page shows none.

## Ingredients

Water, Lecithin, Propanediol, Alcohol, Bellis Perennis Flower Extract, Polymethyl Methacrylate, Peg-40 Hydrogenated Castor Oil, Propylene Glycol, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, 4-Butylresorcinol, Alcohol Denat, Ascorbyl Glucoside, Azelaic Acid, Bha, Bht, Caprylic Capric Triglyceride, Carbomer, Citronellyl Methylcrotonate, Grapefruit Fruit Extract, Diacetyl Boldine, Dipotassium Phosphate, Disodium Edta, Disodium Phosphate, Ethylhexylglycerin, Glycerin, Glycyrrhetinic Acid, Hydrochloric Acid, Hydroxypropyl Cyclodextrin, Melissa Officinalis Leaf Extract, Morus Alba Root Extract, Niacin, Nicotiana Benthamiana Sh-Polypeptide-7, Parfum, Peg Ppg-20 6 Dimethicone, Phenethyl Alcohol, Phenoxyethanol, Polysorbate 20, Potassium Phosphate, Potassium Sorbate, Retinal, Retinol, Sodium Chloride, Sodium Cholate, Sodium Hydroxide, Tocopheryl Acetate, Tranexamic Acid, Triethanolamine, Triisopropanolamine, Undecylenoyl Phenylalanine, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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- United States: https://lovi.care/skincare/p/sesderma/azelac-ru-liposomal-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/sesderma/azelac-ru-liposomal-serum/for/acne-prone-skin
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- United Arab Emirates: https://lovi.care/skincare/ae/p/sesderma/azelac-ru-liposomal-serum/for/acne-prone-skin (this page)