# SENTÉ Dermal Repair Cream for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/ae/p/sente/dermal-repair-cream/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [SENTÉ](https://lovi.care/skincare/ae/brands/sente)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ae/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few moisturizers fit it even better.

## Why this fit

- Highly suitable for your normal skin due to the humectant action of glycerin and sodium hyaluronate, which also offer excellent moisturizing and barrier repair benefits.
- Acetyl glucosamine and sodium hyaluronate provide moderate benefits for wrinkles and fine lines by supporting skin hydration and texture.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components like Argania Spinosa Kernel Oil and Camellia Sinensis Leaf Extract.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/sente/dermal-repair-cream/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/ae/p/sente/dermal-repair-cream/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ae/p/sente/dermal-repair-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ae/p/sente/dermal-repair-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/ae/p/sente/dermal-repair-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ae/p/sente/dermal-repair-cream/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/ae/p/sente/dermal-repair-cream/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/sente/dermal-repair-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/sente/dermal-repair-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Heparan Sulfate Analog, Acetyl Glucosamine, Glycosaminoglycans, Argania Spinosa Kernel Oil

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A topical eye cream containing low molecular weight heparan sulfate and naturally derived extracts improved periorbital hyperpigmentation, fine and coarse wrinkles, puffiness, and dark circles in 15 subjects over 12 weeks. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30636356/))
- Topical low molecular weight heparan sulfate improved periorbital discoloration and wrinkles starting at week two with continuous improvement up to week 12. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32562303/))
- Topical low molecular weight heparan sulfate improved skin hydration, firmness, elasticity, barrier function, and fine lines and wrinkles in 15 patients over 8 weeks. ([Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151781/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Liposomes containing N-acetyl glucosamine prepared using the fusion method significantly increased skin moisture content compared to empty liposomes in human volunteers over a 5-hour period. ([Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23725302/))
- Topical treatment with sphingolipids and glycosaminoglycans attenuated clinical worsening and reduced CADESI and PVAS scores compared to the untreated control group in house dust mite-allergic beagle dogs. ([BMC Veterinary Research, 2020](https://pubmed.ncbi.nlm.nih.gov/32197613/))
- Glycosaminoglycans restored type I collagen synthesis, reduced matrix metalloproteinase-1 levels, upregulated tissue inhibitor of metalloproteinase-1, and attenuated apoptosis in tumor necrosis factor-alpha-stimulated human dermal fibroblasts by inhibiting extracellular signal-regulated kinase/activator protein-1 signaling. ([International Journal of Molecular Medicine, 2018](https://pubmed.ncbi.nlm.nih.gov/29436595/))
- Fraction 3 of glycosaminoglycans from Liparis tessellatus eggs showed 20.1% tyrosinase inhibition at 50mg/mL and effective skin regeneration activities at 200mg/mL against skin fibroblast CCD-986sk cell lines. ([International Journal of Biological Macromolecules, 2017](https://pubmed.ncbi.nlm.nih.gov/28917941/))
- A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events. ([Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/))
- Topical application of an argan oil NLC-based hydrogel formulation increased skin hydration in healthy volunteers over a one-month period through a synergistic effect of NLC occlusion and argan oil hydration. ([International Journal of Nanomedicine, 2014](https://pubmed.ncbi.nlm.nih.gov/25143733/))
- Incorporating allantoin into argan oil enriched liposomes improved its accumulation in the dermis (~8.7μg/cm(2)) and permeation through the skin (~33μg/cm(2)) compared to conventional liposomes, water dispersion, and a commercial gel. ([International Journal of Pharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27063848/))

## What reviewers say

Its lightweight texture absorbs well and is suitable for use under makeup. However, a significant number of users find the high price point to be a drawback, and some with very dry skin may need an additional moisturizer.

- Liked: Reduces redness (mostly mentioned)
- Disliked: Expensive price point (mostly mentioned)
- Liked: Improves texture (often mentioned)
- Liked: Soothing sensitive skin (often mentioned)
- Liked: Lightweight texture (sometimes noted)
- Disliked: Not enough moisture (sometimes noted)
- Disliked: Minor breakouts (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes SENTÉ Dermal Repair Cream a great fit for mature skin?

SENTÉ Dermal Repair Cream is a great fit for mature skin because sodium hyaluronate and glycerin draw in moisture to help smooth and repair the skin barrier. Acetyl glucosamine and sodium hyaluronate also work to improve fine lines and texture, while soothing ingredients like argan oil keep irritation away.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/)

### Which ingredients make this cream a good fit for mature skin?

Sodium hyaluronate and glycerin make this cream a great fit for mature skin by drawing in moisture and repairing the skin barrier, while acetyl glucosamine helps smooth out fine lines and wrinkles. Argania Spinosa kernel oil and green tea extract also keep the skin calm and comfortable with a very low risk of irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### What does Heparan Sulfate Analog do for mature skin?

Heparan Sulfate Analog helps firm mature skin and smooth out lines while restoring a plump, healthy look. It deeply hydrates dry areas to make your skin feel soft and bouncy again.

### Where does this cream go in a skincare routine for mature skin?

This moisturizing treatment goes near the end of your morning routine after a cleanser, hydrating toner, and before SPF, and as the final step in your evening and weekly routines. It helps hydrate and smooth your skin while offering a very safe, irritation-free experience.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this cream with retinol, and in what order?

You can use this moisturizing treatment with retinol by applying it before your retinol at night to help keep your skin calm and hydrated. Using a moisturizing cream with barrier-repair ingredients like glycerin and sodium hyaluronate is unlikely to cause irritation and may make it easier for your skin to adjust to retinol.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

SENTÉ Dermal Repair Cream is a great fit for mature skin and is designed to be used daily as part of your morning and evening routine. Using it twice a day helps improve hydration, softens fine lines, and supports your skin barrier without causing irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores or cause breakouts for mature skin, as it has an excellent safety profile without harsh ingredients and includes soothing components like argan oil and green tea extract.

### Can I use this cream around the eyes or on my body?

This cream is well suited for the thin skin around the eyes and body because its gentle formulation and moisturizing ingredients like sodium hyaluronate and glycerin help hydrate and smooth delicate areas without irritation. Regular application of similar creams containing hyaluronic acid or heparan sulfate is shown to improve fine lines and skin texture in these areas with very good skin tolerance.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [Medi-Peel Peptide 9 Volume Tox Cream](https://lovi.care/skincare/ae/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin) — Superior fit — AED 84.55 at Amazon
- [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/ae/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/mature-skin) — Superior fit — AED 230.55 at Amazon
- [StriVectin SD Advanced Plus Intensive Moisturizing Concentrate](https://lovi.care/skincare/ae/p/strivectin/sd-advanced-plus-intensive-moisturizing-concentrate/for/mature-skin) — High fit — AED 199.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ae/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — AED 84.53 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/ae/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — AED 65.43 at Amazon
- SPF: [SKIN1004 MADAGASCAR CENTELLA AIR-FIT SUNCREAM PLUS](https://lovi.care/skincare/ae/p/skin1004/madagascar-centella-air-fit-suncream-plus/for/mature-skin) — Superior fit — AED 39.45 at Amazon

## Where to buy

- Amazon.ae: AED 663.35 (https://www.amazon.ae/dp/B0CQKNGQ74?tag=lovi00-21&linkCode=osi&th=1&psc=1)
Prices checked 4 Nov 2026.

## Ingredients

Water, Caprylic Capric Triglyceride, C12-15 Alkyl Benzoate, Glycerin, Cetearyl Alcohol, Argania Spinosa Kernel Oil, Heparan Sulfate, Acetyl Glucosamine, Ethylhexyl Palmitate, Glyceryl Stearate, Peg-100 Stearate, Potassium Cetyl Phosphate, Cyclopentasiloxane, Dimethicone, Butylene Glycol, Tocopheryl Acetate, Tocopherol, Sodium Hyaluronate, Camellia Sinensis Leaf Extract, Chenopodium Quinoa Seed Extract, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Aminomethyl Propanol, 1,2-Hexanediol, Caprylyl Glycol, Disodium Edta, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate, Sorbic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/sente/dermal-repair-cream/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/sente/dermal-repair-cream/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/sente/dermal-repair-cream/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/sente/dermal-repair-cream/for/mature-skin
- France: https://lovi.care/skincare/fr/p/sente/dermal-repair-cream/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/sente/dermal-repair-cream/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/sente/dermal-repair-cream/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/sente/dermal-repair-cream/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/sente/dermal-repair-cream/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/sente/dermal-repair-cream/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/sente/dermal-repair-cream/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/sente/dermal-repair-cream/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/sente/dermal-repair-cream/for/mature-skin (this page)