# Peter Thomas Roth Peptide 21 Wrinkle Resist Serum for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: Superior · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ae/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [Peter Thomas Roth](https://lovi.care/skincare/ae/brands/peter-thomas-roth)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate wrinkle reduction for your combination skin, as multiple peptides like Tripeptide-10 Citrulline and Acetyl Octapeptide-3 work to plump and minimize fine lines. Glycerin and Sodium Hyaluronate provide essential hydration, supporting overall skin health.
- While beneficial for combination skin, the formula does not specifically target your oily shine concerns, offering general skincare benefits rather than specialized oil control.
- The product is safe for your combination skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components like Glycerin and Squalane.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ae/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ae/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/ae/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ae/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ae/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ae/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Complex Of 21 Peptides, Neuropeptides, Squalane, Sodium Hyaluronate, Ascorbic Acid, Retinyl Palmitate

## What the research says

- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question. ([The Journal of Clinical and Aesthetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34980969/))
- A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women. ([The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/))
- A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38685700/))

## Why other serums fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## What reviewers say

Users frequently praise this serum for its lightweight, fast-absorbing formula that effectively hydrates and plumps the skin, leading to a visible reduction in fine lines on the forehead and neck. Some users find the product expensive and complain about a sticky residue or a metallic scent.

- Liked: Hydrates and plumps (often mentioned)
- Liked: Reduces fine lines (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Improves texture (sometimes noted)
- Liked: Lightweight absorption (sometimes noted)
- Disliked: Sticky residue (sometimes noted)
- Disliked: Metallic scent (rarely noted)
- Disliked: Packaging issues (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Peter Thomas Roth Peptide 21 Wrinkle Resist Serum work for combination skin?

Peter Thomas Roth Peptide 21 Wrinkle Resist Serum works moderately well for combination skin, offering helpful hydration and smoothing fine lines with peptides and glycerin. However, it does not target oily shine, so combination skin needs a treatment with niacinamide, propolis, or zinc PCA to regulate oiliness and balance hydration.
Sources: [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for combination skin?

This serum fits combination skin well through a complex of multiple peptides along with squalane and sodium hyaluronate, which help plump fine lines and provide essential hydration without irritation. However, combination skin also needs ingredients like niacinamide, propolis, or zinc PCA to regulate oiliness and manage oily shine.
Sources: [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Peptide Complex do for combination skin?

Peptide Complex helps hydrate combination skin, improve elasticity, and smooth the look of lines with daily use. It is unlikely to cause irritation and may also help firm the skin over time.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30834689/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37335808/)

### What do Neuropeptides do for combination skin?

Neuropeptides help support skin barrier repair and keep skin calm when dealing with stress. For combination skin, a product of this type needs soothing ingredients and lightweight hydrators that balance oily and dry areas without clogging pores.
Sources: [The Journal of Allergy and Clinical Immunology, 2024](https://pubmed.ncbi.nlm.nih.gov/38040043/), [Clinics in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22507042/)

### Where does this serum go in a skincare routine for combination skin?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing. Combination skin of this type also needs specialized oil-balancing ingredients to manage oily shine alongside general hydration and wrinkle reduction.

### Can I use this serum with retinol, and in what order?

You can use this treatment in your evening routine after cleansing and toning, and before moisturizing. Since your skin is combination, this type of product needs to incorporate oil-controlling ingredients like niacinamide or salicylic acid to help manage oily shine while providing anti-aging benefits.

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. Combination skin benefits from peptide and hydration serums used consistently, while a product for this skin also needs specialized oil control ingredients to manage shine.
Sources: [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to cause clogged pores, breakouts, or purging for combination skin, as it features a gentle formula free of harsh ingredients. To better suit combination skin, a product of this type needs specialized oil-controlling ingredients to manage oily shine.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Augustinus Bader The Serum](https://lovi.care/skincare/ae/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — AED 1,348.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/ae/p/skinceuticals/c-e-ferulic/for/combination-skin) — Superior fit — AED 715.99 at Amazon
- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/ae/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/combination-skin) — Superior fit — AED 365.22 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ae/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — AED 84.53 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ae/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — AED 145.00 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/ae/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — AED 33.40 at Amazon

## Where to buy

- Amazon.ae: AED 558.05 (https://www.amazon.ae/dp/B00YP582QA?tag=lovi00-21&linkCode=osi&th=1&psc=1)
Prices checked 1 Nov 2026.

## Ingredients

Water, Glycerin, Rosa Centifolia Flower Water, Isopropyl Myristate, Squalane, Mannitol, Butylene Glycol, Natto Gum, Tripeptide-10 Citrulline, Acetyl Octapeptide-3, Palmitoyl Hexapeptide-12, Acetyl Tetrapeptide-11, Acetyl Hexapeptide-8, Acetyl Hexapeptide-1, Palmitoyl Oligopeptide, Acetyl Tetrapeptide-9, Acetyl Tetrapeptide-2, Tripeptide-1, Palmitoyl Tetrapeptide-7, Hexapeptide-11, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Palmitoyl Tripeptide-5, Trifluoroacetyl Tripeptide-2, Palmitoyl Tripeptide-1, Sodium Polyglutamate, Sodium Hyaluronate, Tocopheryl Acetate, Retinyl Palmitate, Ascorbic Acid, Hydrolyzed Soy Protein, Hydrolyzed Wheat Protein, Lecithin, Pseudoalteromonas Extract Ferment, Acrylates Copolymer, Magnesium Chloride, Polysorbate 20, Dimethyl Isosorbide, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Leuconostoc Radish Root Ferment Filtrate, Peg-8 Dimethicone, Disodium Phosphate, Carbomer, Dextran, Sodium Lactate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Xanthan Gum, Triethanolamine, Sodium Phosphate, Octyldodecanol, Silica, Sodium Propoxyhydroxypropyl Thiosulfate Silica, Sodium Hydroxide, Caprylyl Glycol, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/combination-skin (this page)