# Perricone MD Essential Fx Acyl-Glutathione Intensive Overnight Moisturizer for oily skin

**Lovi Fit: Average fit for oily skin.**
Oily Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [Perricone MD](https://lovi.care/skincare/ae/brands/perricone-md)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ae/best/moisturizers)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily skin; other moisturizers fit it better.

## Why this fit

- Offers moderate suitability for oily skin as niacinamide provides some seboregulation, but the formula lacks sufficient mattifying ingredients to optimally address your goal of reducing oily shine.
- The product provides excellent moisturizing benefits due to shea butter and niacinamide, enhancing barrier resilience for your oily skin.
- The safety profile is good, with no risks of irritation for your oily skin due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/oily-skin): Average (this page)
- [Dry skin](https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/oily-acne-prone-skin): Average

## Key ingredients

Acyl-Glutathione, Niacinamide, Shea Butter, Lactic Acid, Vitamin F Blend

## What the research says

- A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events. ([Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39528438/))
- Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin. ([Cutis, 2004](https://pubmed.ncbi.nlm.nih.gov/15027519/))
- Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties. ([Journal of the American Academy of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1597538/))
- A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33178384/))
- Topical application of linoleic acid achieved an almost 25% reduction in the overall size of follicular casts and microcomedones over a 1-month treatment period in patients with mild acne compared to no change at placebo-treated sites. ([Clinical and Experimental Dermatology, 1998](https://pubmed.ncbi.nlm.nih.gov/9692305/))
- Topical conjugated linolenic acid significantly reduced edema on post-procedure Day 3 and itching on Days 1 and 3, and improved wrinkling at Day 14 compared to 1% dimethicone ointment in 34 subjects undergoing fractionated CO2 laser resurfacing of the face. ([The Journal of Clinical and Aesthetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/29344315/))
- Liposomal formulation of linoleic acid significantly enhances its skin whitening effect compared to non-liposomal forms in UV-stimulated guinea pig and human skin. ([Biological & Pharmaceutical Bulletin, 2004](https://pubmed.ncbi.nlm.nih.gov/15056874/))

## Why other moisturizers fit oily skin better

- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## How to apply

- Could be used as part of your AM or PM routine every day to keep your face fresh.
- Apply this moisturizer after cleansing and toning, but right before your SPF in the morning.
- Gently press a small amount into your skin and let it absorb fully.
- Apply on clean, slightly dry skin to help control that oily shine.
- Avoid the eye area and do a quick patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Perricone MD Intensive Overnight Moisturizer work for oily skin?

This moisturizer works reasonably well for oily skin, as niacinamide helps control oil while shea butter strengthens your skin barrier without causing irritation. However, it lacks enough mattifying ingredients to fully reduce oily shine. To work best for oily skin, a moisturizing treatment of this type needs lightweight hydrators and oil-absorbing ingredients that manage shine without clogging pores.
Sources: [Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Which ingredients make this cream a good fit for oily skin?

Niacinamide helps control extra oil and shea butter provides moisture, making it a decent fit for oily skin. To work even better for this skin type, a product of this type needs lightweight textures, oil-absorbing ingredients, and peptides that hydrate without clogging pores.
Sources: [Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Acyl-Glutathione do for oily skin?

Acyl-Glutathione is unlikely to be the best fit for oily skin, as this skin type needs balancing ingredients and lightweight hydrators to control shine and keep pores clear without feeling heavy.

### What does Niacinamide do for oily skin?

Niacinamide helps balance oily skin by significantly reducing excess oil production and shine. It is well tolerated and may improve skin texture without clogging pores.
Sources: [Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this cream go in a skincare routine for oily skin?

This moisturizing treatment goes in the evening routine after your cleansing toner and before your moisturizer. It is unlikely to cause irritation for your oily skin, but an oily skin routine of this type needs mattifying ingredients to reduce shiny areas.

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying it after your retinol treatment to help soothe your skin and keep it soft and comfortable. This type of routine works best for oily skin when it includes ingredients that help control oil and keep shine down.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

This cream works well as a nighttime moisturizing treatment for oily skin, though oily skin needs lightweight, mattifying ingredients and oil-control minerals to keep shine under control.

### Can this cream clog pores, cause breakouts or purging for oily skin?

This cream is unlikely to cause irritation or breakouts on oily skin due to its soothing components and lack of harsh ingredients, though it offers only moderate suitability since it lacks strong mattifying agents to control shine. To properly care for oily skin, a product of this type needs oil-absorbing minerals or lightweight mattifying ingredients that reduce excess oil while keeping the face soft and balanced.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/)

### Can I use this cream around the eyes or on my body?

This moisturizer is generally safe for use on the body, but applying rich formulas with shea butter around the eyes may feel heavy or greasy. When using similar rich treatments on delicate areas like the eyes, oily skin typically needs lightweight, fast-absorbing hydrators that provide moisture without clogging pores or feeling overly heavy.

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (citronellol, limonene, and linalool).

## Alternatives for oily skin

- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/ae/p/cosrx/advanced-snail-96-mucin-power-essence/for/oily-skin) — Superior fit — AED 29.35 at Amazon
- [Anua Heartleaf 78% Soothing Cream](https://lovi.care/skincare/ae/p/anua/heartleaf-78-soothing-cream/for/oily-skin) — Superior fit — AED 71.00 at Amazon
- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/ae/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/oily-skin) — High fit — AED 91.81 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ae/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — AED 49.95 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/ae/p/some-by-mi/snail-truecica-miracle-repair-toner/for/oily-skin) — Superior fit — AED 49.99 at Amazon
- SPF: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/ae/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/oily-skin) — Superior fit — AED 92.70 at Amazon

## Where to buy

No store in United Arab Emirates has a checked price for this product, so the page shows none.

## Ingredients

Water, Butyrospermum Parkii Butter Shea Butter, Myristyl Myristate, Niacinamide, C12-15 Alkyl Benzoate, Stearic Acid, Dimethicone, Sodium Acrylates Copolymer, Palmitoyl Glycine, S-Palmitoylglutathione, Ethylhexylglycerin, Myristyl Laurate, Ribose, Lecithin, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Salvia Hispanica Seed Oil, Magnesium Aspartate, Zinc Gluconate, Copper Gluconate, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Glyceryl Stearate, Peg-100 Stearate, Phenoxyethanol, Citronellol, Hydroxycitronellal, Limonene, Linalool
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/oily-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/oily-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/oily-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/oily-skin (this page)