# Perricone MD Essential Fx Acyl-Glutathione Intensive Overnight Moisturizer for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [Perricone MD](https://lovi.care/skincare/ae/brands/perricone-md)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/ae/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other moisturizers fit it better.

## Why this fit

- Offers moderate suitability for your combination skin, as niacinamide helps with seboregulation and lactic acid provides mild exfoliation, but it lacks sufficient ingredients for optimal oil control on your oily zones.
- The product provides excellent moisturizing due to shea butter and niacinamide, which hydrate and enhance barrier resilience, supporting general skincare benefits for your combination skin.
- The safety profile is good, with no risks of irritation for your combination skin due to the absence of harsh ingredients and the presence of soothing components like niacinamide and shea butter.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/oily-acne-prone-skin): Average

## Key ingredients

Acyl-Glutathione, Niacinamide, Shea Butter, Lactic Acid, Vitamin F Blend

## What the research says

- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events. ([Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/))
- A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39528438/))
- Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin. ([Cutis, 2004](https://pubmed.ncbi.nlm.nih.gov/15027519/))
- Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties. ([Journal of the American Academy of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1597538/))
- A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33178384/))
- Topical application of linoleic acid achieved an almost 25% reduction in the overall size of follicular casts and microcomedones over a 1-month treatment period in patients with mild acne compared to no change at placebo-treated sites. ([Clinical and Experimental Dermatology, 1998](https://pubmed.ncbi.nlm.nih.gov/9692305/))
- Topical conjugated linolenic acid significantly reduced edema on post-procedure Day 3 and itching on Days 1 and 3, and improved wrinkling at Day 14 compared to 1% dimethicone ointment in 34 subjects undergoing fractionated CO2 laser resurfacing of the face. ([The Journal of Clinical and Aesthetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/29344315/))
- Liposomal formulation of linoleic acid significantly enhances its skin whitening effect compared to non-liposomal forms in UV-stimulated guinea pig and human skin. ([Biological & Pharmaceutical Bulletin, 2004](https://pubmed.ncbi.nlm.nih.gov/15056874/))

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Perricone MD Intensive Overnight Moisturizer work for combination skin?

This moisturizer works moderately well for combination skin because niacinamide helps balance oil and lactic acid gently smooths the surface, but it lacks enough ingredients for optimal oil control on your oily zones. It is unlikely to irritate your skin and provides good hydration through shea butter and niacinamide. Combination skin of this type needs formulations with effective brightening and moisturizing ingredients that reduce oily shine while keeping the skin balanced.
Sources: [Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/)

### Which ingredients make this cream a good fit for combination skin?

Niacinamide and lactic acid make this cream a good fit for your combination skin by helping manage oil and gently smoothing the surface, while shea butter provides deep moisture without irritation. However, because it lacks sufficient oil-control ingredients for your oily zones, a product of this type needs stronger oil-balancing and brightening ingredients to truly excel on combination skin.
Sources: [Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/)

### What does Acyl-Glutathione do for combination skin?

Acyl-Glutathione helps brighten skin color and smooth out wrinkles while keeping combination skin hydrated. Topical use of glutathione may improve dark spots and reduce water loss, though its overall effect can vary from person to person.
Sources: [The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30895708/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this cream go in a skincare routine for combination skin?

This cream goes in the evening routine as a moisturizing treatment after cleansing and toning. Combination skin works best with this type of product when it includes strong oil-balancing ingredients to manage oilier zones alongside hydration.

### Can I use this cream with retinol, and in what order?

You can use this moisturizing treatment in the evening after your retinol once your skin is used to it, as its soothing ingredients help keep your skin calm. A product of this type for combination skin needs extra oil-control ingredients to properly manage your shiny zones.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

This moisturizing treatment works well for your combination skin when used daily as part of your evening routine. It provides good moisture and a safe profile, but combination skin needs extra oil-controlling ingredients for your oily zones.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for combination skin?

This cream is unlikely to cause irritation or breakouts on combination skin due to soothing ingredients like niacinamide and shea butter, but it lacks enough oil-controlling ingredients for your oily zones. A product for this skin needs stronger oil-balancing ingredients and lighter hydrators to keep shine in check.
Sources: [Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/)

### Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment around your eyes and on your body, as it has a good safety profile with soothing ingredients like shea butter and niacinamide that are unlikely to cause irritation. Combination skin of this type needs targeted oil-control ingredients and lightweight hydrators to properly balance both oily and dry zones.
Sources: [Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/)

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (citronellol, limonene, and linalool).

## Alternatives for combination skin

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/ae/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/combination-skin) — Superior fit — AED 91.81 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/ae/p/the-ordinary/natural-moisturizing-factors-ha/for/combination-skin) — High fit — AED 65.00 at Amazon
- [Anua Heartleaf 78% Soothing Cream](https://lovi.care/skincare/ae/p/anua/heartleaf-78-soothing-cream/for/combination-skin) — High fit — AED 71.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/ae/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — AED 84.53 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/ae/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — AED 145.00 at Amazon
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/ae/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/combination-skin) — Superior fit — AED 179.45 at Amazon

## Where to buy

No store in United Arab Emirates has a checked price for this product, so the page shows none.

## Ingredients

Water, Butyrospermum Parkii Butter Shea Butter, Myristyl Myristate, Niacinamide, C12-15 Alkyl Benzoate, Stearic Acid, Dimethicone, Sodium Acrylates Copolymer, Palmitoyl Glycine, S-Palmitoylglutathione, Ethylhexylglycerin, Myristyl Laurate, Ribose, Lecithin, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Salvia Hispanica Seed Oil, Magnesium Aspartate, Zinc Gluconate, Copper Gluconate, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Glyceryl Stearate, Peg-100 Stearate, Phenoxyethanol, Citronellol, Hydroxycitronellal, Limonene, Linalool
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/combination-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/combination-skin (this page)