# Perricone MD Cold Plasma Plus+ for skin with dark spots

**Lovi Fit: Average fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/ae/p/perricone-md/cold-plasma-plus/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United Arab Emirates.

Brand: [Perricone MD](https://lovi.care/skincare/ae/brands/perricone-md)
Category: [Serums and treatments](https://lovi.care/skincare/ae/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for skin with dark spots; other serums fit it better.

## Why this fit

- This product offers moderate benefits for your normal skin, with tetrahexyldecyl ascorbate and acetyl hexapeptide-8 working to smooth texture and minimize fine lines. Glycerin and sodium hyaluronate provide essential humectant action, supporting overall skin hydration.
- While it offers general antioxidant support and hydration, it lacks specialized ingredients like potent tyrosinase inhibitors or exfoliants to effectively address your main goal of pigmentation.
- The formulation is safe for your normal skin, as it contains no harsh ingredients that would cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/ae/p/perricone-md/cold-plasma-plus/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/ae/p/perricone-md/cold-plasma-plus/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/ae/p/perricone-md/cold-plasma-plus/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/ae/p/perricone-md/cold-plasma-plus/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/ae/p/perricone-md/cold-plasma-plus/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/ae/p/perricone-md/cold-plasma-plus/for/dark-spots): Average (this page)
- [Mature skin](https://lovi.care/skincare/ae/p/perricone-md/cold-plasma-plus/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/ae/p/perricone-md/cold-plasma-plus/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/ae/p/perricone-md/cold-plasma-plus/for/oily-acne-prone-skin): Average

## Key ingredients

Ascorbic Acid Ester, Copper Tripeptide, Acetyl Hexapeptide-8, Omega 3, Glycolic Acid

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone. ([Dermatologic Surgery, 2017](https://pubmed.ncbi.nlm.nih.gov/28114204/))

## Why other serums fit skin with dark spots better

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))

## What reviewers say

Based on a very large amount of data, users frequently praise this serum for its ability to dramatically smooth rough texture and minimize the appearance of pores, often delivering visible results within a few weeks. While many report firmer, more radiant skin and improved tone, a significant number of reviewers struggle with its distinct scent and high price point.

- Disliked: Unpleasant scent (mostly mentioned)
- Liked: Improves skin texture (often mentioned)
- Disliked: High price tag (often mentioned)
- Liked: Fast absorption (sometimes noted)
- Liked: Increases radiance (sometimes noted)
- Liked: Reduces fine lines (sometimes noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Skin irritation (rarely noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Cold Plasma Plus+ work for skin with dark spots?

This product works for skin with dark spots, though other products fit it better because it lacks specialized ingredients like potent tyrosinase inhibitors to effectively address pigmentation. To properly target dark spots, a product of this type needs specialized brightening ingredients such as niacinamide and powerful antioxidants.

### Which ingredients make this treatment a good fit for skin with dark spots?

This treatment is an average fit for skin with dark spots because it lacks specialized ingredients like potent tyrosinase inhibitors to effectively address pigmentation. To properly target dark spots, a product of this type needs powerful brightening ingredients, potent antioxidants, and soothing elements that tackle discoloration without causing irritation.

### What does Ascorbic Acid do for skin with dark spots?

Ascorbic acid helps fade dark spots and brightens uneven skin. It works by reducing skin pigmentation and improving overall skin tone over time.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/), [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35150043/)

### What does Copper Tripeptide do for skin with dark spots?

Copper Tripeptide helps fade dark spots by supporting skin renewal and tissue remodeling. This ingredient is unlikely to cause irritation and works gradually to give your skin a more even, smooth look.
Sources: [Journal of Biomaterials Science. Polymer Edition, 2008](https://pubmed.ncbi.nlm.nih.gov/18644225/)

### Where does this treatment go in a skincare routine for skin with dark spots?

This treatment goes in the evening routine, applied before your moisturizer. Skin with dark spots needs a product of this type that also includes potent tyrosinase inhibitors or exfoliants to effectively target pigmentation.

### Can I use this treatment with niacinamide, and in what order?

Yes, you can use this treatment with niacinamide by applying niacinamide first and then this treatment once it absorbs. This helps keep your skin smooth and hydrated while providing general antioxidant support.

### How often should I use this treatment?

This product is suitable for evening use, applying it as part of your nighttime routine. To achieve better results for skin with dark spots, a product of this type needs specialized ingredients like potent tyrosinase inhibitors or exfoliants.

### Can this treatment clog pores, cause breakouts or purging for skin with dark spots?

This treatment is unlikely to clog pores or cause breakouts for skin with dark spots because its formulation contains no harsh ingredients that would cause irritation. A product addressing this skin needs potent tyrosinase inhibitors and exfoliants to effectively fade dark spots.

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for skin with dark spots

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/ae/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dark-spots) — Superior fit — AED 347.75 at Amazon
- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/ae/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/dark-spots) — High fit — AED 365.22 at Amazon
- [Guerlain Abeille Royale Double R Renew & Repair Serum](https://lovi.care/skincare/ae/p/guerlain/abeille-royale-double-r-renew-and-repair-advanced-serum/for/dark-spots) — High fit — AED 499.00 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/ae/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — AED 49.95 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/ae/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — AED 64.25 at Amazon
- Moisturizer: [Isntree Green Tea Fresh Serum](https://lovi.care/skincare/ae/p/isntree/green-tea-fresh-serum/for/dark-spots) — Superior fit — AED 75.41 at Amazon

## Where to buy

- Amazon.ae: AED 240.55 (https://www.amazon.ae/dp/B07CNXYFSD?tag=lovi00-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: AED 295.00 (https://www.lookfantastic.ae/p/perricone-md-cold-plasma-fragile-skin-tube/13033740/)
Prices checked 12 Oct – 4 Nov 2026.

## Ingredients

Water, Glycerin, Isopropyl Palmitate, Cetearyl Alcohol, Glyceryl Stearate, Peg-100 Stearate, Butylene Glycol, Phosphatidylcholine, Tetrahexyldecyl Ascorbate, Dimethyl Mea, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-3, Tyrosine, Glycolic Acid, Helianthus Annuus Seed Oil Sunflower Seed Oil, Magnesium Aspartate, Zinc Gluconate, Rosaminus Officinalis Leaf Extract Rosemary Leaf Extract, Copper Gluconate, Sodium Hyaluronate, Retinyl Palmitate, Echium Plantagineum Seed Oil, Hydrolyzed Myrtus Communis Leaf Extract, Copper Tripeptide-1, Dimethicone, Disodium Edta, Carbomer, Ceteareth-20, Cyclopentasiloxane, Caprylyl Glycol, Cyclohexasiloxane, Polysorbate 20, Zea Mays Oil, Phenoxyethanol, Sorbic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/cold-plasma-plus/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/cold-plasma-plus/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/cold-plasma-plus/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/perricone-md/cold-plasma-plus/for/dark-spots
- France: https://lovi.care/skincare/fr/p/perricone-md/cold-plasma-plus/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/perricone-md/cold-plasma-plus/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/cold-plasma-plus/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/perricone-md/cold-plasma-plus/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/perricone-md/cold-plasma-plus/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/cold-plasma-plus/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/cold-plasma-plus/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/cold-plasma-plus/for/dark-spots (this page)